TY - JOUR
T1 - Chasing Jenner's vaccine
T2 - Revisiting Cowpox virus classification
AU - Carroll, Darin S.
AU - Emerson, Ginny L.
AU - Li, Yu
AU - Sammons, Scott
AU - Olson, Victoria
AU - Frace, Michael
AU - Nakazawa, Yoshinori
AU - Czerny, Claus Peter
AU - Tryland, Morten
AU - Kolodziejek, Jolanta
AU - Nowotny, Norbert
AU - Olsen-Rasmussen, Melissa
AU - Khristova, Marina
AU - Govil, Dhwani
AU - Karem, Kevin
AU - Damon, Inger K.
AU - Meyer, Hermann
PY - 2011
Y1 - 2011
N2 - Cowpox virus (CPXV) is described as the source of the first vaccine used to prevent the onset and spread of an infectious disease. It is one of the earliest described members of the genus Orthopoxvirus, which includes the viruses that cause smallpox and monkeypox in humans. Both the historic and current literature describe "cowpox" as a disease with a single etiologic agent. Genotypic data presented herein indicate that CPXV is not a single species, but a composite of several (up to 5) species that can infect cows, humans, and other animals. The practice of naming agents after the host in which the resultant disease manifests obfuscates the true taxonomic relationships of "cowpox" isolates. These data support the elevation of as many as four new species within the traditional "cowpox" group and suggest that both wild and modern vaccine strains of Vaccinia virus are most closely related to CPXV of continental Europe rather than the United Kingdom, the homeland of the vaccine.
AB - Cowpox virus (CPXV) is described as the source of the first vaccine used to prevent the onset and spread of an infectious disease. It is one of the earliest described members of the genus Orthopoxvirus, which includes the viruses that cause smallpox and monkeypox in humans. Both the historic and current literature describe "cowpox" as a disease with a single etiologic agent. Genotypic data presented herein indicate that CPXV is not a single species, but a composite of several (up to 5) species that can infect cows, humans, and other animals. The practice of naming agents after the host in which the resultant disease manifests obfuscates the true taxonomic relationships of "cowpox" isolates. These data support the elevation of as many as four new species within the traditional "cowpox" group and suggest that both wild and modern vaccine strains of Vaccinia virus are most closely related to CPXV of continental Europe rather than the United Kingdom, the homeland of the vaccine.
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U2 - 10.1371/journal.pone.0023086
DO - 10.1371/journal.pone.0023086
M3 - Article
C2 - 21858000
AN - SCOPUS:79961202383
SN - 1932-6203
VL - 6
JO - PLoS One
JF - PLoS One
IS - 8
M1 - e23086
ER -
