Changes in the FEV1/FVC ratio during childhood and adolescence

An intercontinental study

P. H. Quanjer, S. Stanojevic, J. Stocks, G. L. Hall, K. V V Prasad, T. J. Cole, M. Rosenthal, R. Perez-Padilla, J. L. Hankinson, E. Falaschetti, M. Golshan, B. Brunekreef, O. Al-Rawas, J. Kühr, Y. Trabelsi, M. S M Ip

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

In children, the ratio of forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) is reportedly constant or falls linearly with age, whereas the ratio of residual volume (RV) to total lung capacity (TLC) remains constant. This seems counter-intuitive given the changes in airway properties, body proportions, thoracic shape and respiratory muscle function that occur during growth. The age dependence of lung volumes, FEV1/FVC and RV/TLC were studied in children worldwide. Spirometric data were available for 22,412 healthy youths (51.4% male) aged 4-20 yrs from 15 centres, and RV and TLC data for 2,253 youths (56.7% male) from four centres; three sets included sitting height (SH). Data were fitted as a function of age, height and SH. In childhood, FVC outgrows TLC and FEV1, leading to falls in FEV1/FVC and RV/TLC; these trends are reversed in adolescence. Taking into account SH materially reduces differences in pulmonary function within and between ethnic groups. The highest FEV1/FVC ratios occur in those shortest for their age. When interpreting lung function test results, the changing pattern in FEV1/FVC and RV/TLC should be considered. Prediction equations for children and adolescents should take into account sex, height, age, ethnic group, and, ideally, also SH. Copyright

Original languageEnglish
Pages (from-to)1391-1399
Number of pages9
JournalEuropean Respiratory Journal
Volume36
Issue number6
DOIs
Publication statusPublished - Dec 1 2010

Fingerprint

Total Lung Capacity
Vital Capacity
Forced Expiratory Volume
Residual Volume
Ethnic Groups
Lung
Respiratory Muscles
Respiratory Function Tests
Thorax
Age Groups
Growth

Keywords

  • Ethnicity
  • Growth and development
  • Lung volume measurements
  • Sitting height
  • Thorax

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Medicine(all)

Cite this

Quanjer, P. H., Stanojevic, S., Stocks, J., Hall, G. L., Prasad, K. V. V., Cole, T. J., ... Ip, M. S. M. (2010). Changes in the FEV1/FVC ratio during childhood and adolescence: An intercontinental study. European Respiratory Journal, 36(6), 1391-1399. https://doi.org/10.1183/09031936.00164109

Changes in the FEV1/FVC ratio during childhood and adolescence : An intercontinental study. / Quanjer, P. H.; Stanojevic, S.; Stocks, J.; Hall, G. L.; Prasad, K. V V; Cole, T. J.; Rosenthal, M.; Perez-Padilla, R.; Hankinson, J. L.; Falaschetti, E.; Golshan, M.; Brunekreef, B.; Al-Rawas, O.; Kühr, J.; Trabelsi, Y.; Ip, M. S M.

In: European Respiratory Journal, Vol. 36, No. 6, 01.12.2010, p. 1391-1399.

Research output: Contribution to journalArticle

Quanjer, PH, Stanojevic, S, Stocks, J, Hall, GL, Prasad, KVV, Cole, TJ, Rosenthal, M, Perez-Padilla, R, Hankinson, JL, Falaschetti, E, Golshan, M, Brunekreef, B, Al-Rawas, O, Kühr, J, Trabelsi, Y & Ip, MSM 2010, 'Changes in the FEV1/FVC ratio during childhood and adolescence: An intercontinental study', European Respiratory Journal, vol. 36, no. 6, pp. 1391-1399. https://doi.org/10.1183/09031936.00164109
Quanjer, P. H. ; Stanojevic, S. ; Stocks, J. ; Hall, G. L. ; Prasad, K. V V ; Cole, T. J. ; Rosenthal, M. ; Perez-Padilla, R. ; Hankinson, J. L. ; Falaschetti, E. ; Golshan, M. ; Brunekreef, B. ; Al-Rawas, O. ; Kühr, J. ; Trabelsi, Y. ; Ip, M. S M. / Changes in the FEV1/FVC ratio during childhood and adolescence : An intercontinental study. In: European Respiratory Journal. 2010 ; Vol. 36, No. 6. pp. 1391-1399.
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