Cerium Oxide Nanoparticles in Lung Acutely Induce Oxidative Stress, Inflammation, and DNA Damage in Various Organs of Mice

Abderrahim Nemmar, Priya Yuvaraju, Sumaya Beegam, Mohamed A. Fahim, Badreldin H. Ali

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

CeO2 nanoparticles (CeO2 NPs) which are used as a diesel fuel additive are emitted in the particulate phase in the exhaust, posing a health concern. However, limited information exists regarding the in vivo acute toxicity of CeO2 NPs on multiple organs. Presently, we investigated the acute (24 h) effects of intratracheally instilled CeO2 NPs in mice (0.5 mg/kg) on oxidative stress, inflammation, and DNA damage in major organs including lung, heart, liver, kidneys, spleen, and brain. Lipid peroxidation measured by malondialdehyde production was increased in the lungs only, and reactive oxygen species were increased in the lung, heart, kidney, and brain. Superoxide dismutase activity was decreased in the lung, liver, and kidney, whereas glutathione increased in lung but it decreased in the kidney. Total nitric oxide was increased in the lung and spleen but it decreased in the heart. Tumour necrosis factor-α increased in all organs studied. Interleukin- (IL-) 6 increased in the lung, heart, liver, kidney, and spleen. IL-1β augmented in the lung, heart, kidney, and spleen. Moreover, CeO2 NPs induced DNA damage, assessed by COMET assay, in all organs studied. Collectively, these findings indicate that pulmonary exposure to CeO2 NPs causes oxidative stress, inflammation, and DNA damage in multiple organs.

Original languageEnglish
Article number9639035
JournalOxidative Medicine and Cellular Longevity
Volume2017
DOIs
Publication statusPublished - 2017

Fingerprint

Oxidative stress
Nanoparticles
DNA Damage
Oxidative Stress
Inflammation
Lung
Liver
DNA
Kidney
Spleen
Brain
Fuel additives
Diesel fuels
Malondialdehyde
Interleukin-1
Superoxide Dismutase
Glutathione
Toxicity
Interleukin-6
Assays

ASJC Scopus subject areas

  • Biochemistry
  • Ageing
  • Cell Biology

Cite this

Cerium Oxide Nanoparticles in Lung Acutely Induce Oxidative Stress, Inflammation, and DNA Damage in Various Organs of Mice. / Nemmar, Abderrahim; Yuvaraju, Priya; Beegam, Sumaya; Fahim, Mohamed A.; Ali, Badreldin H.

In: Oxidative Medicine and Cellular Longevity, Vol. 2017, 9639035, 2017.

Research output: Contribution to journalArticle

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