Cerebrospinal fluid involvement in a case of visceral leishmaniasis associated with hemophagocytic lymphohistiocytosis

Mahmoud Fathalla, Javad Hashim, Hussein Alkindy, Yasser Wali

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Hemophagocytic Lymphohistiocytosis (HLH) implies a benign generalized histiocytic proliferate with erythrophagocytosis and it includes familial hemophagocytic lymphohistiocytosis and secondary hemophgocytosis. Spinal fluid changes like mild to moderate pleocytosis (most of the cells are lymphocytes and macrophages) and sometimes hemophagocytosis are seen in primary HLH but are not reported in secondary HLH. Here we report a case of a previously healthy 10 months old male infant who was diagnosed as familial HLH with evidence of CSF hemophagocytosis. He was started on the HLH 2004 treatment protocol with no improvement. A second bone marrow aspiration revealed leshmania donovani antibodies and he was started on anti-leishmania treatment with dramatic response.To the best of our knowledge, this is the first case of secondary HLH with evidence of hemophagocytosis in cerebrospinal fluid.

Original languageEnglish
Pages (from-to)253-256
Number of pages4
JournalSultan Qaboos University Medical Journal
Volume7
Issue number3
Publication statusPublished - Dec 1 2007

Keywords

  • Case Report
  • Cerebrospinal fluid
  • Hemophagocytic
  • Leishmaniasis
  • Lymphohistiocytosis
  • Oman

ASJC Scopus subject areas

  • Medicine(all)

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