Central nervous system activity of Leucas inflata Benth. In mice

M. H. Al-Yousuf, B. H. Ali, A. K. Bashir, M. O M Tanira, G. Blunden

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The analgesic activity of the methanol and acetone extracts of Leucas inflata L. (family Labiatae) was evaluated in mice using different experimental models. The effect of the two extracts on pentobarbitone-sleeping time, motor activity, sensorimotor coordination, carrageen induced inflammation, and brewer's yeast-induced pyrexia has also been investigated. The two crude extracts have been phytochemically analyzed and some constituents isolated and characterized. These included stigmasterols, a chromone and coumarins. Extracts of L. inflata L., given at single oral doses of 0.25, 0.5, 1.0 or 2.0 g/kg, significantly and dose-dependently, reduced formalin-induced pain, acetic acid induced abdominal constrictions and increased the reaction time in the hot-plate test. Both extracts caused significant and dose-related impairment in the sensorimotor control and ambulatory and total motor activity of treated mice. Both extracts exhibited anti-inflammatory action by reducing paw edema of treated mice. The extracts did not significantly affect the rectal temperature of normothermic mice. However, they were effective in preventing Brewers yeast induced pyrexia. It is concluded that the crude methanol and acetone extract of L. inflata has CNS depressant properties, manifested as antinociception and sedation. Both extracts have anti-inflammatory and antipyretic actions.

Original languageEnglish
Pages (from-to)501-507
Number of pages7
JournalPhytomedicine
Volume9
Issue number6
Publication statusPublished - Sep 2002

Fingerprint

Leucas
Neurology
Acetone
Yeast
central nervous system
Methanol
Anti-Inflammatory Agents
Central Nervous System
Chromones
Central Nervous System Depressants
Stigmasterol
Coumarins
Antipyretics
mice
extracts
Pentobarbital
Complex Mixtures
Acetic Acid
Formaldehyde
Saccharomyces cerevisiae

Keywords

  • Antinociception
  • CNS depression
  • Leucas inflata
  • Mice
  • Sedation

ASJC Scopus subject areas

  • Plant Science
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Al-Yousuf, M. H., Ali, B. H., Bashir, A. K., Tanira, M. O. M., & Blunden, G. (2002). Central nervous system activity of Leucas inflata Benth. In mice. Phytomedicine, 9(6), 501-507.

Central nervous system activity of Leucas inflata Benth. In mice. / Al-Yousuf, M. H.; Ali, B. H.; Bashir, A. K.; Tanira, M. O M; Blunden, G.

In: Phytomedicine, Vol. 9, No. 6, 09.2002, p. 501-507.

Research output: Contribution to journalArticle

Al-Yousuf, MH, Ali, BH, Bashir, AK, Tanira, MOM & Blunden, G 2002, 'Central nervous system activity of Leucas inflata Benth. In mice', Phytomedicine, vol. 9, no. 6, pp. 501-507.
Al-Yousuf, M. H. ; Ali, B. H. ; Bashir, A. K. ; Tanira, M. O M ; Blunden, G. / Central nervous system activity of Leucas inflata Benth. In mice. In: Phytomedicine. 2002 ; Vol. 9, No. 6. pp. 501-507.
@article{3591bf067a394d098cd153d75b2c8f0b,
title = "Central nervous system activity of Leucas inflata Benth. In mice",
abstract = "The analgesic activity of the methanol and acetone extracts of Leucas inflata L. (family Labiatae) was evaluated in mice using different experimental models. The effect of the two extracts on pentobarbitone-sleeping time, motor activity, sensorimotor coordination, carrageen induced inflammation, and brewer's yeast-induced pyrexia has also been investigated. The two crude extracts have been phytochemically analyzed and some constituents isolated and characterized. These included stigmasterols, a chromone and coumarins. Extracts of L. inflata L., given at single oral doses of 0.25, 0.5, 1.0 or 2.0 g/kg, significantly and dose-dependently, reduced formalin-induced pain, acetic acid induced abdominal constrictions and increased the reaction time in the hot-plate test. Both extracts caused significant and dose-related impairment in the sensorimotor control and ambulatory and total motor activity of treated mice. Both extracts exhibited anti-inflammatory action by reducing paw edema of treated mice. The extracts did not significantly affect the rectal temperature of normothermic mice. However, they were effective in preventing Brewers yeast induced pyrexia. It is concluded that the crude methanol and acetone extract of L. inflata has CNS depressant properties, manifested as antinociception and sedation. Both extracts have anti-inflammatory and antipyretic actions.",
keywords = "Antinociception, CNS depression, Leucas inflata, Mice, Sedation",
author = "Al-Yousuf, {M. H.} and Ali, {B. H.} and Bashir, {A. K.} and Tanira, {M. O M} and G. Blunden",
year = "2002",
month = "9",
language = "English",
volume = "9",
pages = "501--507",
journal = "Phytomedicine",
issn = "0944-7113",
publisher = "Urban und Fischer Verlag Jena",
number = "6",

}

TY - JOUR

T1 - Central nervous system activity of Leucas inflata Benth. In mice

AU - Al-Yousuf, M. H.

AU - Ali, B. H.

AU - Bashir, A. K.

AU - Tanira, M. O M

AU - Blunden, G.

PY - 2002/9

Y1 - 2002/9

N2 - The analgesic activity of the methanol and acetone extracts of Leucas inflata L. (family Labiatae) was evaluated in mice using different experimental models. The effect of the two extracts on pentobarbitone-sleeping time, motor activity, sensorimotor coordination, carrageen induced inflammation, and brewer's yeast-induced pyrexia has also been investigated. The two crude extracts have been phytochemically analyzed and some constituents isolated and characterized. These included stigmasterols, a chromone and coumarins. Extracts of L. inflata L., given at single oral doses of 0.25, 0.5, 1.0 or 2.0 g/kg, significantly and dose-dependently, reduced formalin-induced pain, acetic acid induced abdominal constrictions and increased the reaction time in the hot-plate test. Both extracts caused significant and dose-related impairment in the sensorimotor control and ambulatory and total motor activity of treated mice. Both extracts exhibited anti-inflammatory action by reducing paw edema of treated mice. The extracts did not significantly affect the rectal temperature of normothermic mice. However, they were effective in preventing Brewers yeast induced pyrexia. It is concluded that the crude methanol and acetone extract of L. inflata has CNS depressant properties, manifested as antinociception and sedation. Both extracts have anti-inflammatory and antipyretic actions.

AB - The analgesic activity of the methanol and acetone extracts of Leucas inflata L. (family Labiatae) was evaluated in mice using different experimental models. The effect of the two extracts on pentobarbitone-sleeping time, motor activity, sensorimotor coordination, carrageen induced inflammation, and brewer's yeast-induced pyrexia has also been investigated. The two crude extracts have been phytochemically analyzed and some constituents isolated and characterized. These included stigmasterols, a chromone and coumarins. Extracts of L. inflata L., given at single oral doses of 0.25, 0.5, 1.0 or 2.0 g/kg, significantly and dose-dependently, reduced formalin-induced pain, acetic acid induced abdominal constrictions and increased the reaction time in the hot-plate test. Both extracts caused significant and dose-related impairment in the sensorimotor control and ambulatory and total motor activity of treated mice. Both extracts exhibited anti-inflammatory action by reducing paw edema of treated mice. The extracts did not significantly affect the rectal temperature of normothermic mice. However, they were effective in preventing Brewers yeast induced pyrexia. It is concluded that the crude methanol and acetone extract of L. inflata has CNS depressant properties, manifested as antinociception and sedation. Both extracts have anti-inflammatory and antipyretic actions.

KW - Antinociception

KW - CNS depression

KW - Leucas inflata

KW - Mice

KW - Sedation

UR - http://www.scopus.com/inward/record.url?scp=0036746295&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036746295&partnerID=8YFLogxK

M3 - Article

C2 - 12403158

AN - SCOPUS:0036746295

VL - 9

SP - 501

EP - 507

JO - Phytomedicine

JF - Phytomedicine

SN - 0944-7113

IS - 6

ER -