Cellular proliferation in the lymphoid tissues of an inbred (Rt1a) rat strain during the oestrous cycle

O. Habbal, G. Leeming, J. M. McLean

Research output: Contribution to journalArticle

Abstract

Changes in body weight, uterine weight and tissue weight, cell content and cellular proliferation of the thymus and uterine regional and popliteal lymph nodes were examined at daily intervals during the oestrous cycle of the DA (RT1a) inbred rat strain.Thirty-nine sexually mature virgin animals, aged between 13 and 15 weeks were used in this investigation. During dioestrus body weight and uterine weight fell significantly, while intrathymic and in-tranodal cellular proliferation increased significantly.These findings are discussed in relation to ovarian hormone secretion and it is suggested that increased thymocyte and lymphocyte proliferation occurs in response to rising oestrogen levels. This proliferative response prepares the female for the immunological challenge with allogeneic spermatozoa should mating occur during the subsequent oestrous phase.

Original languageEnglish
Pages (from-to)156-160
Number of pages5
JournalCells Tissues Organs
Volume131
Issue number2
DOIs
Publication statusPublished - 1988

Fingerprint

Inbred Strains Rats
Lymphoid Tissue
Cell Proliferation
Weights and Measures
Diestrus
Body Weight Changes
Thymocytes
Thymus Gland
Spermatozoa
Estrogens
Lymph Nodes
Body Weight
Hormones
Lymphocytes

Keywords

  • Lymphocyte proliferation
  • Oestrous cycle-Thymus

ASJC Scopus subject areas

  • Anatomy
  • Histology

Cite this

Cellular proliferation in the lymphoid tissues of an inbred (Rt1a) rat strain during the oestrous cycle. / Habbal, O.; Leeming, G.; McLean, J. M.

In: Cells Tissues Organs, Vol. 131, No. 2, 1988, p. 156-160.

Research output: Contribution to journalArticle

@article{9219901b3791403fab4cf45a9122446c,
title = "Cellular proliferation in the lymphoid tissues of an inbred (Rt1a) rat strain during the oestrous cycle",
abstract = "Changes in body weight, uterine weight and tissue weight, cell content and cellular proliferation of the thymus and uterine regional and popliteal lymph nodes were examined at daily intervals during the oestrous cycle of the DA (RT1a) inbred rat strain.Thirty-nine sexually mature virgin animals, aged between 13 and 15 weeks were used in this investigation. During dioestrus body weight and uterine weight fell significantly, while intrathymic and in-tranodal cellular proliferation increased significantly.These findings are discussed in relation to ovarian hormone secretion and it is suggested that increased thymocyte and lymphocyte proliferation occurs in response to rising oestrogen levels. This proliferative response prepares the female for the immunological challenge with allogeneic spermatozoa should mating occur during the subsequent oestrous phase.",
keywords = "Lymphocyte proliferation, Oestrous cycle-Thymus",
author = "O. Habbal and G. Leeming and McLean, {J. M.}",
year = "1988",
doi = "10.1159/000146505",
language = "English",
volume = "131",
pages = "156--160",
journal = "Cells Tissues Organs",
issn = "1422-6405",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Cellular proliferation in the lymphoid tissues of an inbred (Rt1a) rat strain during the oestrous cycle

AU - Habbal, O.

AU - Leeming, G.

AU - McLean, J. M.

PY - 1988

Y1 - 1988

N2 - Changes in body weight, uterine weight and tissue weight, cell content and cellular proliferation of the thymus and uterine regional and popliteal lymph nodes were examined at daily intervals during the oestrous cycle of the DA (RT1a) inbred rat strain.Thirty-nine sexually mature virgin animals, aged between 13 and 15 weeks were used in this investigation. During dioestrus body weight and uterine weight fell significantly, while intrathymic and in-tranodal cellular proliferation increased significantly.These findings are discussed in relation to ovarian hormone secretion and it is suggested that increased thymocyte and lymphocyte proliferation occurs in response to rising oestrogen levels. This proliferative response prepares the female for the immunological challenge with allogeneic spermatozoa should mating occur during the subsequent oestrous phase.

AB - Changes in body weight, uterine weight and tissue weight, cell content and cellular proliferation of the thymus and uterine regional and popliteal lymph nodes were examined at daily intervals during the oestrous cycle of the DA (RT1a) inbred rat strain.Thirty-nine sexually mature virgin animals, aged between 13 and 15 weeks were used in this investigation. During dioestrus body weight and uterine weight fell significantly, while intrathymic and in-tranodal cellular proliferation increased significantly.These findings are discussed in relation to ovarian hormone secretion and it is suggested that increased thymocyte and lymphocyte proliferation occurs in response to rising oestrogen levels. This proliferative response prepares the female for the immunological challenge with allogeneic spermatozoa should mating occur during the subsequent oestrous phase.

KW - Lymphocyte proliferation

KW - Oestrous cycle-Thymus

UR - http://www.scopus.com/inward/record.url?scp=84940627988&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940627988&partnerID=8YFLogxK

U2 - 10.1159/000146505

DO - 10.1159/000146505

M3 - Article

VL - 131

SP - 156

EP - 160

JO - Cells Tissues Organs

JF - Cells Tissues Organs

SN - 1422-6405

IS - 2

ER -