Cellular proliferation in the lymphoid tissues of an inbred (RT1a) rat strain during the oestrous cycle

O. Habbal, G. Leeming, J. M. McLean

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Changes in body weight, uterine weight and tissue weight, cell content and cellular proliferation of the thymus and uterine regional and popliteal lymph nodes were examined at daily intervals during the oestrous cycle of the DA (RT1a) inbred rat strain. Thirty-nine sexually mature virgin animals, aged between 13 and 15 weeks were used in this investigation. During dioestrus body weight and uterine weight fell significantly, while intrathymic and intranodal cellular proliferation increased significantly. These findings are discussed in relation to ovarian hormone secretion and it is suggested that increased thymocyte and lymphocyte proliferation occurs in response to rising oestrogen levels. This proliferative response prepares the female for the immunological challenge with allogenic spermatozoa should mating occur during the subsequent oestrous phase.

Original languageEnglish
Pages (from-to)156-160
Number of pages5
JournalActa Anatomica
Volume131
Issue number2
Publication statusPublished - 1988

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Inbred Strains Rats
Lymphoid Tissue
Cell Proliferation
Weights and Measures
Diestrus
Body Weight Changes
Thymocytes
Thymus Gland
Spermatozoa
Estrogens
Lymph Nodes
Body Weight
Hormones
Lymphocytes

ASJC Scopus subject areas

  • Anatomy

Cite this

Cellular proliferation in the lymphoid tissues of an inbred (RT1a) rat strain during the oestrous cycle. / Habbal, O.; Leeming, G.; McLean, J. M.

In: Acta Anatomica, Vol. 131, No. 2, 1988, p. 156-160.

Research output: Contribution to journalArticle

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