Calcitonin gene-related peptide is a venous dilator in conscious rats

Aly Abdelrahman, Catherine C.Y. Pang

Research output: Contribution to journalComment/debate

Abstract

The effect of calcitonin gene-related peptide (CGRP) on body venous tone is not known. This study examines the dose-response effects of rat αCGRP on mean circulatory filling pressure (MCFP), an index of body venous tone, in conscious rats. Dose-response curves of CGRP were constructed in three groups of rats, namely, (I) intact, (III) rats pretreated with the ganglionic blocker hexamethonium and (V) rats pretreated with noradrenaline to raise mean arterial pressure (MAP) and MCFP. Three additional groups, (II), (IV) and (VI), served as time controls and were treated similarly to (I), (III) and (V), respectively, except that they were given saline (0.9% NaCl) in place of CGRP. The infusion of CGRP in intact rats dose dependently decreased MAP, increased heart rate (HR) and slightly reduced MCFP. In ganglionic-blocked rats, CGRP caused similar depressor responses but less tachycardia than in intact rats, however, it also slightly reduced MCFP. In rats given noradrenaline, CGRP dose dependently decreased MAP, MCFP and increased HR. The results show that CGRP has venodilator activities; its venous effect is best revealed at elevated venous tone.

Original languageEnglish
Number of pages1
JournalEuropean Journal of Pharmacology
Volume230
Issue number3
Publication statusPublished - Jan 19 1993

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Keywords

  • CGRP (calcitonin gene-related peptide)
  • Circulatory filling pressure (mean)
  • Ganglionic blockers
  • Noradrenaline
  • Venous tone

ASJC Scopus subject areas

  • Pharmacology

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