BRIP1, a potential candidate gene in development of non-BRCA1/2 breast cancer

Allal Ouhtit; Ishita Gupta; Zoya Shaikh

BRIP1, a potential candidate gene in development of non-BRCA1/2 breast cancer

Allal Ouhtit, Ishita Gupta, Zoya Shaikh

Genetics

Research output: Contribution to journal › Review article › peer-review

12 Citations (Scopus)

Abstract

BRIP1 encodes a protein belonging to the RecQ DEAH helicase family. It interacts with BRCA1, and is involved in the repair of DNA damage and tumor suppression. Aberrations in BRIP1 have been mainly associated with the development of breast cancer (BC), ovarian cancer, and type J Fanconi anemia. Based on recent work, we hypothesize that BRIP1 might be the gene involved in the onset of BC in families that do not show BRACA1/2 mutations. This review will focus on the findings supporting this hypothesis, the mechanisms linking BRIP1 to the onset of BC, and the potential clinical relevance of its various inhibitors.

Original language	English
Pages (from-to)	289-298
Number of pages	10
Journal	Frontiers in Bioscience - Elite
Volume	8
Publication status	Published - 2016

ASJC Scopus subject areas

Medicine(all)
Immunology and Microbiology(all)
Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'BRIP1, a potential candidate gene in development of non-BRCA1/2 breast cancer'. Together they form a unique fingerprint.

Cite this

@article{052cff72f302493996c2e2e2a0735088,

title = "BRIP1, a potential candidate gene in development of non-BRCA1/2 breast cancer",

abstract = "BRIP1 encodes a protein belonging to the RecQ DEAH helicase family. It interacts with BRCA1, and is involved in the repair of DNA damage and tumor suppression. Aberrations in BRIP1 have been mainly associated with the development of breast cancer (BC), ovarian cancer, and type J Fanconi anemia. Based on recent work, we hypothesize that BRIP1 might be the gene involved in the onset of BC in families that do not show BRACA1/2 mutations. This review will focus on the findings supporting this hypothesis, the mechanisms linking BRIP1 to the onset of BC, and the potential clinical relevance of its various inhibitors. ",

author = "Allal Ouhtit and Ishita Gupta and Zoya Shaikh",

year = "2016",

language = "English",

volume = "8",

pages = "289--298",

journal = "Frontiers in Bioscience - Elite",

issn = "1945-0494",

publisher = "Frontiers in Bioscience",

}

TY - JOUR

T1 - BRIP1, a potential candidate gene in development of non-BRCA1/2 breast cancer

AU - Ouhtit, Allal

AU - Gupta, Ishita

AU - Shaikh, Zoya

PY - 2016

Y1 - 2016

N2 - BRIP1 encodes a protein belonging to the RecQ DEAH helicase family. It interacts with BRCA1, and is involved in the repair of DNA damage and tumor suppression. Aberrations in BRIP1 have been mainly associated with the development of breast cancer (BC), ovarian cancer, and type J Fanconi anemia. Based on recent work, we hypothesize that BRIP1 might be the gene involved in the onset of BC in families that do not show BRACA1/2 mutations. This review will focus on the findings supporting this hypothesis, the mechanisms linking BRIP1 to the onset of BC, and the potential clinical relevance of its various inhibitors.

AB - BRIP1 encodes a protein belonging to the RecQ DEAH helicase family. It interacts with BRCA1, and is involved in the repair of DNA damage and tumor suppression. Aberrations in BRIP1 have been mainly associated with the development of breast cancer (BC), ovarian cancer, and type J Fanconi anemia. Based on recent work, we hypothesize that BRIP1 might be the gene involved in the onset of BC in families that do not show BRACA1/2 mutations. This review will focus on the findings supporting this hypothesis, the mechanisms linking BRIP1 to the onset of BC, and the potential clinical relevance of its various inhibitors.

UR - http://www.scopus.com/inward/record.url?scp=84991373124&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84991373124&partnerID=8YFLogxK

M3 - Review article

C2 - 26709662

AN - SCOPUS:84991373124

VL - 8

SP - 289

EP - 298

JO - Frontiers in Bioscience - Elite

JF - Frontiers in Bioscience - Elite

SN - 1945-0494

ER -

BRIP1, a potential candidate gene in development of non-BRCA1/2 breast cancer

Abstract

ASJC Scopus subject areas

Other files and links

Cite this