Abstract
BRIP1 encodes a protein belonging to the RecQ DEAH helicase family. It interacts with BRCA1, and is involved in the repair of DNA damage and tumor suppression. Aberrations in BRIP1 have been mainly associated with the development of breast cancer (BC), ovarian cancer, and type J Fanconi anemia. Based on recent work, we hypothesize that BRIP1 might be the gene involved in the onset of BC in families that do not show BRACA1/2 mutations. This review will focus on the findings supporting this hypothesis, the mechanisms linking BRIP1 to the onset of BC, and the potential clinical relevance of its various inhibitors.
| Original language | English |
|---|---|
| Pages (from-to) | 289-298 |
| Number of pages | 10 |
| Journal | Frontiers in Bioscience - Elite |
| Volume | 8 |
| Publication status | Published - 2016 |
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ASJC Scopus subject areas
- Medicine(all)
- Immunology and Microbiology(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
BRIP1, a potential candidate gene in development of non-BRCA1/2 breast cancer. / Ouhtit, Allal; Gupta, Ishita; Shaikh, Zoya.
In: Frontiers in Bioscience - Elite, Vol. 8, 2016, p. 289-298.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - BRIP1, a potential candidate gene in development of non-BRCA1/2 breast cancer
AU - Ouhtit, Allal
AU - Gupta, Ishita
AU - Shaikh, Zoya
PY - 2016
Y1 - 2016
N2 - BRIP1 encodes a protein belonging to the RecQ DEAH helicase family. It interacts with BRCA1, and is involved in the repair of DNA damage and tumor suppression. Aberrations in BRIP1 have been mainly associated with the development of breast cancer (BC), ovarian cancer, and type J Fanconi anemia. Based on recent work, we hypothesize that BRIP1 might be the gene involved in the onset of BC in families that do not show BRACA1/2 mutations. This review will focus on the findings supporting this hypothesis, the mechanisms linking BRIP1 to the onset of BC, and the potential clinical relevance of its various inhibitors.
AB - BRIP1 encodes a protein belonging to the RecQ DEAH helicase family. It interacts with BRCA1, and is involved in the repair of DNA damage and tumor suppression. Aberrations in BRIP1 have been mainly associated with the development of breast cancer (BC), ovarian cancer, and type J Fanconi anemia. Based on recent work, we hypothesize that BRIP1 might be the gene involved in the onset of BC in families that do not show BRACA1/2 mutations. This review will focus on the findings supporting this hypothesis, the mechanisms linking BRIP1 to the onset of BC, and the potential clinical relevance of its various inhibitors.
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M3 - Review article
VL - 8
SP - 289
EP - 298
JO - Frontiers in Bioscience - Elite
JF - Frontiers in Bioscience - Elite
SN - 1945-0494
ER -