Bone metabolism and histomorphometric changes in murine models treated with sclerostin antibody: A systematic review

Srijit Das, Rajalingham Sakthiswary*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Preventing osteoporotic fractures in millions of individuals may significantly reduce the associated morbidity and health-care expenditures incurred. As such, the search for newer anti-osteoporotic agents has been ongoing for years. Genetic studies have proven that the secreted protein sclerostin is one of the main culprits, which negatively regulates the bone formation. Recently, sclerostin-neutralizing monoclonal antibodies (Scl-Ab) in rodent studies have shown positive effects on bone homeostasis. An extensive search of the literature was performed in the BIOSIS, Cinahl, EMBASE, Pub-Med, Web of Science and Cochrane Library databases to evaluate the published murine studies on the effects of Scl-Ab on the bone metabolism and histomorphometric parameters. Our systematic review depicts a significant association between Scl-Ab administration and improvement in bone formation, bone density, bone volume and trabecular thickness.

Original languageEnglish
Pages (from-to)1667-1674
Number of pages8
JournalCurrent Drug Targets
Volume14
Issue number14
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • Bone formation
  • Bone histomorphometry
  • Bone metabolism
  • Sclerostin antibody

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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