Blockade of the renin-angiotensin system at different sites

Effect on renin, angiotensin and aldosterone

A. M. Abdelrahman, L. M. Burrell, C. I. Johnston

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Inhibition of renin-angiotensin system: It is now possible to effectively block the renin-angiotensin system at several steps by orally active inhibitors. Blockade of renin, the angiotensin converting enzyme (ACE) or the angiotensin II (Ang II) type 1 (AT1) receptor leads to different hormonal changes. All three modes of blockade reduce aldosterone and all cause a reactive rise in plasma renin due to removal of angiotensin II tonic inhibition on renal renin release. Associated changes in Ang I and Ang II: AT1 blockade by losartan is followed by rises in plasma Ang I and Ang II; ACE inhibitors are associated with an increase in plasma Ang I but a fall in Ang II, whereas both plasma Ang I and Ang II fall with renin inhibition. Differences in mode of inhibition: Potential differences between the mode of blockade of the renin-angiotensin system include differences in the bioavailability of compounds, the effect of ACE on other peptide substrates, particularly bradykinin, the possibility of other actions or unknown substrates for renin and the presence of unblocked AT2 angiotensin receptors in the presence of high levels of Ang II. Whether these will result in clinically important differences remains to be determined.

Original languageEnglish
JournalJournal of Hypertension
Volume11
Issue numberSUPPL. 3
Publication statusPublished - 1993

Fingerprint

Angiotensins
Renin-Angiotensin System
Aldosterone
Renin
Angiotensin II
Peptidyl-Dipeptidase A
Angiotensin Type 2 Receptor
Angiotensinogen
Angiotensin Type 1 Receptor
Losartan
Bradykinin
Angiotensin-Converting Enzyme Inhibitors
Biological Availability
Kidney
Peptides

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Blockade of the renin-angiotensin system at different sites : Effect on renin, angiotensin and aldosterone. / Abdelrahman, A. M.; Burrell, L. M.; Johnston, C. I.

In: Journal of Hypertension, Vol. 11, No. SUPPL. 3, 1993.

Research output: Contribution to journalArticle

@article{260fcaf5ecea47d688b357758f070b4d,
title = "Blockade of the renin-angiotensin system at different sites: Effect on renin, angiotensin and aldosterone",
abstract = "Inhibition of renin-angiotensin system: It is now possible to effectively block the renin-angiotensin system at several steps by orally active inhibitors. Blockade of renin, the angiotensin converting enzyme (ACE) or the angiotensin II (Ang II) type 1 (AT1) receptor leads to different hormonal changes. All three modes of blockade reduce aldosterone and all cause a reactive rise in plasma renin due to removal of angiotensin II tonic inhibition on renal renin release. Associated changes in Ang I and Ang II: AT1 blockade by losartan is followed by rises in plasma Ang I and Ang II; ACE inhibitors are associated with an increase in plasma Ang I but a fall in Ang II, whereas both plasma Ang I and Ang II fall with renin inhibition. Differences in mode of inhibition: Potential differences between the mode of blockade of the renin-angiotensin system include differences in the bioavailability of compounds, the effect of ACE on other peptide substrates, particularly bradykinin, the possibility of other actions or unknown substrates for renin and the presence of unblocked AT2 angiotensin receptors in the presence of high levels of Ang II. Whether these will result in clinically important differences remains to be determined.",
author = "Abdelrahman, {A. M.} and Burrell, {L. M.} and Johnston, {C. I.}",
year = "1993",
language = "English",
volume = "11",
journal = "Journal of Hypertension",
issn = "0263-6352",
publisher = "Lippincott Williams and Wilkins",
number = "SUPPL. 3",

}

TY - JOUR

T1 - Blockade of the renin-angiotensin system at different sites

T2 - Effect on renin, angiotensin and aldosterone

AU - Abdelrahman, A. M.

AU - Burrell, L. M.

AU - Johnston, C. I.

PY - 1993

Y1 - 1993

N2 - Inhibition of renin-angiotensin system: It is now possible to effectively block the renin-angiotensin system at several steps by orally active inhibitors. Blockade of renin, the angiotensin converting enzyme (ACE) or the angiotensin II (Ang II) type 1 (AT1) receptor leads to different hormonal changes. All three modes of blockade reduce aldosterone and all cause a reactive rise in plasma renin due to removal of angiotensin II tonic inhibition on renal renin release. Associated changes in Ang I and Ang II: AT1 blockade by losartan is followed by rises in plasma Ang I and Ang II; ACE inhibitors are associated with an increase in plasma Ang I but a fall in Ang II, whereas both plasma Ang I and Ang II fall with renin inhibition. Differences in mode of inhibition: Potential differences between the mode of blockade of the renin-angiotensin system include differences in the bioavailability of compounds, the effect of ACE on other peptide substrates, particularly bradykinin, the possibility of other actions or unknown substrates for renin and the presence of unblocked AT2 angiotensin receptors in the presence of high levels of Ang II. Whether these will result in clinically important differences remains to be determined.

AB - Inhibition of renin-angiotensin system: It is now possible to effectively block the renin-angiotensin system at several steps by orally active inhibitors. Blockade of renin, the angiotensin converting enzyme (ACE) or the angiotensin II (Ang II) type 1 (AT1) receptor leads to different hormonal changes. All three modes of blockade reduce aldosterone and all cause a reactive rise in plasma renin due to removal of angiotensin II tonic inhibition on renal renin release. Associated changes in Ang I and Ang II: AT1 blockade by losartan is followed by rises in plasma Ang I and Ang II; ACE inhibitors are associated with an increase in plasma Ang I but a fall in Ang II, whereas both plasma Ang I and Ang II fall with renin inhibition. Differences in mode of inhibition: Potential differences between the mode of blockade of the renin-angiotensin system include differences in the bioavailability of compounds, the effect of ACE on other peptide substrates, particularly bradykinin, the possibility of other actions or unknown substrates for renin and the presence of unblocked AT2 angiotensin receptors in the presence of high levels of Ang II. Whether these will result in clinically important differences remains to be determined.

UR - http://www.scopus.com/inward/record.url?scp=0027481053&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027481053&partnerID=8YFLogxK

M3 - Article

VL - 11

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - SUPPL. 3

ER -