Birthweight and the risk of atopic diseases: The ISAAC Phase III study

Edwin A. Mitchell; Tadd Clayton; Luis García-Marcos; Neil Pearce; Sunia Foliaki; Gary Wong; N. Aït-Khaled; H. R. Anderson; M. I. Asher; R. Beasley; B. Björkstén; B. Brunekreef; J. Crane; P. Ellwood; C. Flohr; F. Forastiere; U. Keil; C. K.W. Lai; J. Mallol; S. Montefort; J. Odhiambo; C. F. Robertson; A. W. Stewart; D. Strachan; E. von Mutius; S. K. Weiland; G. Weinmayr; H. Williams; E. Ellwood; L. de Freitas Souza; D. Rennie; P. Aguilar; L. Amarales; G. Aristizábal; A. M. Cepeda; M. A. Riikjärv; G. Zsigmond; S. N. Mantri; A. V. Pherwani; S. Rego; S. Salvi; S. K. Sharma; T. U. Sukumaran; P. S. Suresh Babu; C. B. Kartasasmita; M. R. Masjedi; A. Steriu; H. Odajima; C. Imanalieva; J. Kudzyte; B. S. Quah; K. H. Teh; M. Baeza-Bacab; M. Barragán-Meijueiro; B. E. Del-Río-Navarro; R. García-Almaráz; S. N. González-Díaz; F. J. Linares-Zapién; J. V. Merida-Palacio; R. MacKay; C. Moyes; P. Pattemore; A. Brêborowicz; G. Lis; R. Câmara; J. M. Lopes dos Santos; C. Nunes; J. E. Rosado Pinto; D. Y.T. Goh; H. B. Lee; R. M. Busquets; I. Carvajal-Urueña; G. García-Hernández; C. González Diáaz; A. Ĺopez-Silvarrey Varela; M. M. Morales-Suárez-Varela; O. Al-Rawas; S. Mohammad; Y. Mohammad; J. L. Huang; C. C. Kao; M. Trakultivakorn; P. Vichyanond; M. C. Lapides; Dirceu Solé; Malcolm Sears; Vivianna Aguirre; Jayant Shah; Karnen Baratawidjaja; Sankei Nishima; Jessie de Bruyne; Bee Wah Lee; Dolores Holgado

doi:10.1111/pai.12210

Birthweight and the risk of atopic diseases: The ISAAC Phase III study

Edwin A. Mitchell^*, Tadd Clayton, Luis García-Marcos, Neil Pearce, Sunia Foliaki, Gary Wong, N. Aït-Khaled, H. R. Anderson, M. I. Asher, R. Beasley, B. Björkstén, B. Brunekreef, J. Crane, P. Ellwood, C. Flohr, F. Forastiere, U. Keil, C. K.W. Lai, J. Mallol, S. MontefortJ. Odhiambo, C. F. Robertson, A. W. Stewart, D. Strachan, E. von Mutius, S. K. Weiland, G. Weinmayr, H. Williams, E. Ellwood, L. de Freitas Souza, D. Rennie, P. Aguilar, L. Amarales, G. Aristizábal, A. M. Cepeda, M. A. Riikjärv, G. Zsigmond, S. N. Mantri, A. V. Pherwani, S. Rego, S. Salvi, S. K. Sharma, T. U. Sukumaran, P. S. Suresh Babu, C. B. Kartasasmita, M. R. Masjedi, A. Steriu, H. Odajima, C. Imanalieva, J. Kudzyte, B. S. Quah, K. H. Teh, M. Baeza-Bacab, M. Barragán-Meijueiro, B. E. Del-Río-Navarro, R. García-Almaráz, S. N. González-Díaz, F. J. Linares-Zapién, J. V. Merida-Palacio, R. MacKay, C. Moyes, P. Pattemore, A. Brêborowicz, G. Lis, R. Câmara, J. M. Lopes dos Santos, C. Nunes, J. E. Rosado Pinto, D. Y.T. Goh, H. B. Lee, R. M. Busquets, I. Carvajal-Urueña, G. García-Hernández, C. González Diáaz, A. Ĺopez-Silvarrey Varela, M. M. Morales-Suárez-Varela, O. Al-Rawas, S. Mohammad, Y. Mohammad, J. L. Huang, C. C. Kao, M. Trakultivakorn, P. Vichyanond, M. C. Lapides, Dirceu Solé, Malcolm Sears, Vivianna Aguirre, Jayant Shah, Karnen Baratawidjaja, Sankei Nishima, Jessie de Bruyne, Bee Wah Lee, Dolores Holgado

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Background: The association between birthweight and asthma, eczema and rhinoconjunctivitis is conflicting. Aims: To examine the association between birthweight and symptoms of asthma, eczema and rhinoconjunctivitis. Methods: Parents or guardians of children aged 6-7 yr completed written questionnaires about symptoms of asthma, rhinoconjunctivitis and eczema, and several risk factors, including birthweight. Results: There were 162,324 children from 60 centres in 26 countries. Low birthweight (<2.5 kg) was associated with an increased risk of symptoms of asthma (current wheeze odds ratio = 1.20; 95% confidence interval = 1.12-1.30). Low birthweight was associated with a lower risk of eczema ever. Low birthweight was not associated with rhinoconjunctivitis. Large babies (birthweight ≥4.5 kg) were not associated with any of these outcomes. Conclusions: This study has confirmed that low birthweight is a risk factor for symptoms of asthma, but not for rhinoconjunctivitis. The findings for eczema are equivocal.

Original language	English
Pages (from-to)	264-270
Number of pages	7
Journal	Pediatric Allergy and Immunology
Volume	25
Issue number	3
DOIs	https://doi.org/10.1111/pai.12210
Publication status	Published - May 1 2014
Externally published	Yes

Keywords

Asthma
Eczema
ISAAC
Low birthweight
Rhinoconjunctivitis
Risk factors

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Immunology and Allergy
Immunology

Access to Document

10.1111/pai.12210

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Mitchell, E. A., Clayton, T., García-Marcos, L., Pearce, N., Foliaki, S., Wong, G., Aït-Khaled, N., Anderson, H. R., Asher, M. I., Beasley, R., Björkstén, B., Brunekreef, B., Crane, J., Ellwood, P., Flohr, C., Forastiere, F., Keil, U., Lai, C. K. W., Mallol, J., ... Holgado, D. (2014). Birthweight and the risk of atopic diseases: The ISAAC Phase III study. Pediatric Allergy and Immunology, 25(3), 264-270. https://doi.org/10.1111/pai.12210

Mitchell, EA, Clayton, T, García-Marcos, L, Pearce, N, Foliaki, S, Wong, G, Aït-Khaled, N, Anderson, HR, Asher, MI, Beasley, R, Björkstén, B, Brunekreef, B, Crane, J, Ellwood, P, Flohr, C, Forastiere, F, Keil, U, Lai, CKW, Mallol, J, Montefort, S, Odhiambo, J, Robertson, CF, Stewart, AW, Strachan, D, von Mutius, E, Weiland, SK, Weinmayr, G, Williams, H, Ellwood, E, de Freitas Souza, L, Rennie, D, Aguilar, P, Amarales, L, Aristizábal, G, Cepeda, AM, Riikjärv, MA, Zsigmond, G, Mantri, SN, Pherwani, AV, Rego, S, Salvi, S, Sharma, SK, Sukumaran, TU, Suresh Babu, PS, Kartasasmita, CB, Masjedi, MR, Steriu, A, Odajima, H, Imanalieva, C, Kudzyte, J, Quah, BS, Teh, KH, Baeza-Bacab, M, Barragán-Meijueiro, M, Del-Río-Navarro, BE, García-Almaráz, R, González-Díaz, SN, Linares-Zapién, FJ, Merida-Palacio, JV, MacKay, R, Moyes, C, Pattemore, P, Brêborowicz, A, Lis, G, Câmara, R, Lopes dos Santos, JM, Nunes, C, Rosado Pinto, JE, Goh, DYT, Lee, HB, Busquets, RM, Carvajal-Urueña, I, García-Hernández, G, González Diáaz, C, Ĺopez-Silvarrey Varela, A, Morales-Suárez-Varela, MM, Al-Rawas, O, Mohammad, S, Mohammad, Y, Huang, JL, Kao, CC, Trakultivakorn, M, Vichyanond, P, Lapides, MC, Solé, D, Sears, M, Aguirre, V, Shah, J, Baratawidjaja, K, Nishima, S, de Bruyne, J, Lee, BW & Holgado, D 2014, 'Birthweight and the risk of atopic diseases: The ISAAC Phase III study', Pediatric Allergy and Immunology, vol. 25, no. 3, pp. 264-270. https://doi.org/10.1111/pai.12210

@article{f3665cfda5bf4ee2a238fda32eb550de,

title = "Birthweight and the risk of atopic diseases: The ISAAC Phase III study",

abstract = "Background: The association between birthweight and asthma, eczema and rhinoconjunctivitis is conflicting. Aims: To examine the association between birthweight and symptoms of asthma, eczema and rhinoconjunctivitis. Methods: Parents or guardians of children aged 6-7 yr completed written questionnaires about symptoms of asthma, rhinoconjunctivitis and eczema, and several risk factors, including birthweight. Results: There were 162,324 children from 60 centres in 26 countries. Low birthweight (<2.5 kg) was associated with an increased risk of symptoms of asthma (current wheeze odds ratio = 1.20; 95% confidence interval = 1.12-1.30). Low birthweight was associated with a lower risk of eczema ever. Low birthweight was not associated with rhinoconjunctivitis. Large babies (birthweight ≥4.5 kg) were not associated with any of these outcomes. Conclusions: This study has confirmed that low birthweight is a risk factor for symptoms of asthma, but not for rhinoconjunctivitis. The findings for eczema are equivocal.",

keywords = "Asthma, Eczema, ISAAC, Low birthweight, Rhinoconjunctivitis, Risk factors",

author = "Mitchell, {Edwin A.} and Tadd Clayton and Luis Garc{\'i}a-Marcos and Neil Pearce and Sunia Foliaki and Gary Wong and N. A{\"i}t-Khaled and Anderson, {H. R.} and Asher, {M. I.} and R. Beasley and B. Bj{\"o}rkst{\'e}n and B. Brunekreef and J. Crane and P. Ellwood and C. Flohr and F. Forastiere and U. Keil and Lai, {C. K.W.} and J. Mallol and S. Montefort and J. Odhiambo and Robertson, {C. F.} and Stewart, {A. W.} and D. Strachan and {von Mutius}, E. and Weiland, {S. K.} and G. Weinmayr and H. Williams and E. Ellwood and {de Freitas Souza}, L. and D. Rennie and P. Aguilar and L. Amarales and G. Aristiz{\'a}bal and Cepeda, {A. M.} and Riikj{\"a}rv, {M. A.} and G. Zsigmond and Mantri, {S. N.} and Pherwani, {A. V.} and S. Rego and S. Salvi and Sharma, {S. K.} and Sukumaran, {T. U.} and {Suresh Babu}, {P. S.} and Kartasasmita, {C. B.} and Masjedi, {M. R.} and A. Steriu and H. Odajima and C. Imanalieva and J. Kudzyte and Quah, {B. S.} and Teh, {K. H.} and M. Baeza-Bacab and M. Barrag{\'a}n-Meijueiro and Del-R{\'i}o-Navarro, {B. E.} and R. Garc{\'i}a-Almar{\'a}z and Gonz{\'a}lez-D{\'i}az, {S. N.} and Linares-Zapi{\'e}n, {F. J.} and Merida-Palacio, {J. V.} and R. MacKay and C. Moyes and P. Pattemore and A. Br{\^e}borowicz and G. Lis and R. C{\^a}mara and {Lopes dos Santos}, {J. M.} and C. Nunes and {Rosado Pinto}, {J. E.} and Goh, {D. Y.T.} and Lee, {H. B.} and Busquets, {R. M.} and I. Carvajal-Urue{\~n}a and G. Garc{\'i}a-Hern{\'a}ndez and {Gonz{\'a}lez Di{\'a}az}, C. and {{\'L}opez-Silvarrey Varela}, A. and Morales-Su{\'a}rez-Varela, {M. M.} and O. Al-Rawas and S. Mohammad and Y. Mohammad and Huang, {J. L.} and Kao, {C. C.} and M. Trakultivakorn and P. Vichyanond and Lapides, {M. C.} and Dirceu Sol{\'e} and Malcolm Sears and Vivianna Aguirre and Jayant Shah and Karnen Baratawidjaja and Sankei Nishima and {de Bruyne}, Jessie and Lee, {Bee Wah} and Dolores Holgado",

year = "2014",

month = may,

day = "1",

doi = "10.1111/pai.12210",

language = "English",

volume = "25",

pages = "264--270",

journal = "Pediatric Allergy and Immunology",

issn = "0905-6157",

publisher = "Blackwell Munksgaard",

number = "3",

}

TY - JOUR

T1 - Birthweight and the risk of atopic diseases

T2 - The ISAAC Phase III study

AU - Mitchell, Edwin A.

AU - Clayton, Tadd

AU - García-Marcos, Luis

AU - Pearce, Neil

AU - Foliaki, Sunia

AU - Wong, Gary

AU - Aït-Khaled, N.

AU - Anderson, H. R.

AU - Asher, M. I.

AU - Beasley, R.

AU - Björkstén, B.

AU - Brunekreef, B.

AU - Crane, J.

AU - Ellwood, P.

AU - Flohr, C.

AU - Forastiere, F.

AU - Keil, U.

AU - Lai, C. K.W.

AU - Mallol, J.

AU - Montefort, S.

AU - Odhiambo, J.

AU - Robertson, C. F.

AU - Stewart, A. W.

AU - Strachan, D.

AU - von Mutius, E.

AU - Weiland, S. K.

AU - Weinmayr, G.

AU - Williams, H.

AU - Ellwood, E.

AU - de Freitas Souza, L.

AU - Rennie, D.

AU - Aguilar, P.

AU - Amarales, L.

AU - Aristizábal, G.

AU - Cepeda, A. M.

AU - Riikjärv, M. A.

AU - Zsigmond, G.

AU - Mantri, S. N.

AU - Pherwani, A. V.

AU - Rego, S.

AU - Salvi, S.

AU - Sharma, S. K.

AU - Sukumaran, T. U.

AU - Suresh Babu, P. S.

AU - Kartasasmita, C. B.

AU - Masjedi, M. R.

AU - Steriu, A.

AU - Odajima, H.

AU - Imanalieva, C.

AU - Kudzyte, J.

AU - Quah, B. S.

AU - Teh, K. H.

AU - Baeza-Bacab, M.

AU - Barragán-Meijueiro, M.

AU - Del-Río-Navarro, B. E.

AU - García-Almaráz, R.

AU - González-Díaz, S. N.

AU - Linares-Zapién, F. J.

AU - Merida-Palacio, J. V.

AU - MacKay, R.

AU - Moyes, C.

AU - Pattemore, P.

AU - Brêborowicz, A.

AU - Lis, G.

AU - Câmara, R.

AU - Lopes dos Santos, J. M.

AU - Nunes, C.

AU - Rosado Pinto, J. E.

AU - Goh, D. Y.T.

AU - Lee, H. B.

AU - Busquets, R. M.

AU - Carvajal-Urueña, I.

AU - García-Hernández, G.

AU - González Diáaz, C.

AU - Ĺopez-Silvarrey Varela, A.

AU - Morales-Suárez-Varela, M. M.

AU - Al-Rawas, O.

AU - Mohammad, S.

AU - Mohammad, Y.

AU - Huang, J. L.

AU - Kao, C. C.

AU - Trakultivakorn, M.

AU - Vichyanond, P.

AU - Lapides, M. C.

AU - Solé, Dirceu

AU - Sears, Malcolm

AU - Aguirre, Vivianna

AU - Shah, Jayant

AU - Baratawidjaja, Karnen

AU - Nishima, Sankei

AU - de Bruyne, Jessie

AU - Lee, Bee Wah

AU - Holgado, Dolores

PY - 2014/5/1

Y1 - 2014/5/1

N2 - Background: The association between birthweight and asthma, eczema and rhinoconjunctivitis is conflicting. Aims: To examine the association between birthweight and symptoms of asthma, eczema and rhinoconjunctivitis. Methods: Parents or guardians of children aged 6-7 yr completed written questionnaires about symptoms of asthma, rhinoconjunctivitis and eczema, and several risk factors, including birthweight. Results: There were 162,324 children from 60 centres in 26 countries. Low birthweight (<2.5 kg) was associated with an increased risk of symptoms of asthma (current wheeze odds ratio = 1.20; 95% confidence interval = 1.12-1.30). Low birthweight was associated with a lower risk of eczema ever. Low birthweight was not associated with rhinoconjunctivitis. Large babies (birthweight ≥4.5 kg) were not associated with any of these outcomes. Conclusions: This study has confirmed that low birthweight is a risk factor for symptoms of asthma, but not for rhinoconjunctivitis. The findings for eczema are equivocal.

AB - Background: The association between birthweight and asthma, eczema and rhinoconjunctivitis is conflicting. Aims: To examine the association between birthweight and symptoms of asthma, eczema and rhinoconjunctivitis. Methods: Parents or guardians of children aged 6-7 yr completed written questionnaires about symptoms of asthma, rhinoconjunctivitis and eczema, and several risk factors, including birthweight. Results: There were 162,324 children from 60 centres in 26 countries. Low birthweight (<2.5 kg) was associated with an increased risk of symptoms of asthma (current wheeze odds ratio = 1.20; 95% confidence interval = 1.12-1.30). Low birthweight was associated with a lower risk of eczema ever. Low birthweight was not associated with rhinoconjunctivitis. Large babies (birthweight ≥4.5 kg) were not associated with any of these outcomes. Conclusions: This study has confirmed that low birthweight is a risk factor for symptoms of asthma, but not for rhinoconjunctivitis. The findings for eczema are equivocal.

KW - Asthma

KW - Eczema

KW - ISAAC

KW - Low birthweight

KW - Rhinoconjunctivitis

KW - Risk factors

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UR - http://www.scopus.com/inward/citedby.url?scp=84898833349&partnerID=8YFLogxK

U2 - 10.1111/pai.12210

DO - 10.1111/pai.12210

M3 - Article

C2 - 24750571

AN - SCOPUS:84898833349

SN - 0905-6157

VL - 25

SP - 264

EP - 270

JO - Pediatric Allergy and Immunology

JF - Pediatric Allergy and Immunology

IS - 3

ER -

Birthweight and the risk of atopic diseases: The ISAAC Phase III study

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