Birthweight and the risk of atopic diseases

The ISAAC Phase III study

Edwin A. Mitchell, Tadd Clayton, Luis García-Marcos, Neil Pearce, Sunia Foliaki, Gary Wong, N. Aït-Khaled, H. R. Anderson, M. I. Asher, R. Beasley, B. Björkstén, B. Brunekreef, J. Crane, P. Ellwood, C. Flohr, S. Foliaki, F. Forastiere, L. Garciáa-Marcos, U. Keil, C. K W Lai & 85 others J. Mallol, E. A. Mitchell, S. Montefort, J. Odhiambo, N. Pearce, C. F. Robertson, A. W. Stewart, D. Strachan, E. von Mutius, S. K. Weiland, G. Weinmayr, H. Williams, G. Wong, M. I. Asher, T. O. Clayton, E. Ellwood, P. Ellwood, E. A. Mitchell, A. W. Stewart, L. de Freitas Souza, D. Rennie, P. Aguilar, L. Amarales, G. Aristizábal, A. M. Cepeda, M. A. Riikjärv, G. Zsigmond, S. N. Mantri, A. V. Pherwani, S. Rego, S. Salvi, S. K. Sharma, T. U. Sukumaran, P. S. Suresh Babu, C. B. Kartasasmita, M. R. Masjedi, A. Steriu, H. Odajima, C. Imanalieva, J. Kudzyte, B. S. Quah, K. H. Teh, M. Baeza-Bacab, M. Barragán-Meijueiro, B. E. Del-Río-Navarro, R. García-Almaráz, S. N. González-Díaz, F. J. Linares-Zapién, J. V. Merida-Palacio, M. I. Asher, R. MacKay, C. Moyes, P. Pattemore, A. Brêborowicz, G. Lis, R. Câmara, Omar AL-Rawas, C. Nunes, J. E. Rosado Pinto, D. Y T Goh, H. B. Lee, R. M. Busquets, I. Carvajal-Urueña, G. García-Hernández, L. García-Marcos, C. González Diáaz, A. Ĺopez-Silvarrey Varela, M. M. Morales-Suárez-Varela, O. Al-Rawas, S. Mohammad, Y. Mohammad, J. L. Huang, C. C. Kao, M. Trakultivakorn, P. Vichyanond, M. C. Lapides, Dirceu Solé, Malcolm Sears, Vivianna Aguirre, Jayant Shah, Karnen Baratawidjaja, Sankei Nishima, Jessie de Bruyne, Bee Wah Lee, Dolores Holgado

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: The association between birthweight and asthma, eczema and rhinoconjunctivitis is conflicting. Aims: To examine the association between birthweight and symptoms of asthma, eczema and rhinoconjunctivitis. Methods: Parents or guardians of children aged 6-7 yr completed written questionnaires about symptoms of asthma, rhinoconjunctivitis and eczema, and several risk factors, including birthweight. Results: There were 162,324 children from 60 centres in 26 countries. Low birthweight (<2.5 kg) was associated with an increased risk of symptoms of asthma (current wheeze odds ratio = 1.20; 95% confidence interval = 1.12-1.30). Low birthweight was associated with a lower risk of eczema ever. Low birthweight was not associated with rhinoconjunctivitis. Large babies (birthweight ≥4.5 kg) were not associated with any of these outcomes. Conclusions: This study has confirmed that low birthweight is a risk factor for symptoms of asthma, but not for rhinoconjunctivitis. The findings for eczema are equivocal.

Original languageEnglish
Pages (from-to)264-270
Number of pages7
JournalPediatric Allergy and Immunology
Volume25
Issue number3
DOIs
Publication statusPublished - 2014

Fingerprint

Eczema
Asthma
Parents
Odds Ratio
Confidence Intervals

Keywords

  • Asthma
  • Eczema
  • ISAAC
  • Low birthweight
  • Rhinoconjunctivitis
  • Risk factors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Immunology

Cite this

Mitchell, E. A., Clayton, T., García-Marcos, L., Pearce, N., Foliaki, S., Wong, G., ... Holgado, D. (2014). Birthweight and the risk of atopic diseases: The ISAAC Phase III study. Pediatric Allergy and Immunology, 25(3), 264-270. https://doi.org/10.1111/pai.12210

Birthweight and the risk of atopic diseases : The ISAAC Phase III study. / Mitchell, Edwin A.; Clayton, Tadd; García-Marcos, Luis; Pearce, Neil; Foliaki, Sunia; Wong, Gary; Aït-Khaled, N.; Anderson, H. R.; Asher, M. I.; Beasley, R.; Björkstén, B.; Brunekreef, B.; Crane, J.; Ellwood, P.; Flohr, C.; Foliaki, S.; Forastiere, F.; Garciáa-Marcos, L.; Keil, U.; Lai, C. K W; Mallol, J.; Mitchell, E. A.; Montefort, S.; Odhiambo, J.; Pearce, N.; Robertson, C. F.; Stewart, A. W.; Strachan, D.; von Mutius, E.; Weiland, S. K.; Weinmayr, G.; Williams, H.; Wong, G.; Asher, M. I.; Clayton, T. O.; Ellwood, E.; Ellwood, P.; Mitchell, E. A.; Stewart, A. W.; de Freitas Souza, L.; Rennie, D.; Aguilar, P.; Amarales, L.; Aristizábal, G.; Cepeda, A. M.; Riikjärv, M. A.; Zsigmond, G.; Mantri, S. N.; Pherwani, A. V.; Rego, S.; Salvi, S.; Sharma, S. K.; Sukumaran, T. U.; Suresh Babu, P. S.; Kartasasmita, C. B.; Masjedi, M. R.; Steriu, A.; Odajima, H.; Imanalieva, C.; Kudzyte, J.; Quah, B. S.; Teh, K. H.; Baeza-Bacab, M.; Barragán-Meijueiro, M.; Del-Río-Navarro, B. E.; García-Almaráz, R.; González-Díaz, S. N.; Linares-Zapién, F. J.; Merida-Palacio, J. V.; Asher, M. I.; MacKay, R.; Moyes, C.; Pattemore, P.; Brêborowicz, A.; Lis, G.; Câmara, R.; AL-Rawas, Omar; Nunes, C.; Rosado Pinto, J. E.; Goh, D. Y T; Lee, H. B.; Busquets, R. M.; Carvajal-Urueña, I.; García-Hernández, G.; García-Marcos, L.; González Diáaz, C.; Ĺopez-Silvarrey Varela, A.; Morales-Suárez-Varela, M. M.; Al-Rawas, O.; Mohammad, S.; Mohammad, Y.; Huang, J. L.; Kao, C. C.; Trakultivakorn, M.; Vichyanond, P.; Lapides, M. C.; Solé, Dirceu; Sears, Malcolm; Aguirre, Vivianna; Shah, Jayant; Baratawidjaja, Karnen; Nishima, Sankei; de Bruyne, Jessie; Lee, Bee Wah; Holgado, Dolores.

In: Pediatric Allergy and Immunology, Vol. 25, No. 3, 2014, p. 264-270.

Research output: Contribution to journalArticle

Mitchell, EA, Clayton, T, García-Marcos, L, Pearce, N, Foliaki, S, Wong, G, Aït-Khaled, N, Anderson, HR, Asher, MI, Beasley, R, Björkstén, B, Brunekreef, B, Crane, J, Ellwood, P, Flohr, C, Foliaki, S, Forastiere, F, Garciáa-Marcos, L, Keil, U, Lai, CKW, Mallol, J, Mitchell, EA, Montefort, S, Odhiambo, J, Pearce, N, Robertson, CF, Stewart, AW, Strachan, D, von Mutius, E, Weiland, SK, Weinmayr, G, Williams, H, Wong, G, Asher, MI, Clayton, TO, Ellwood, E, Ellwood, P, Mitchell, EA, Stewart, AW, de Freitas Souza, L, Rennie, D, Aguilar, P, Amarales, L, Aristizábal, G, Cepeda, AM, Riikjärv, MA, Zsigmond, G, Mantri, SN, Pherwani, AV, Rego, S, Salvi, S, Sharma, SK, Sukumaran, TU, Suresh Babu, PS, Kartasasmita, CB, Masjedi, MR, Steriu, A, Odajima, H, Imanalieva, C, Kudzyte, J, Quah, BS, Teh, KH, Baeza-Bacab, M, Barragán-Meijueiro, M, Del-Río-Navarro, BE, García-Almaráz, R, González-Díaz, SN, Linares-Zapién, FJ, Merida-Palacio, JV, Asher, MI, MacKay, R, Moyes, C, Pattemore, P, Brêborowicz, A, Lis, G, Câmara, R, AL-Rawas, O, Nunes, C, Rosado Pinto, JE, Goh, DYT, Lee, HB, Busquets, RM, Carvajal-Urueña, I, García-Hernández, G, García-Marcos, L, González Diáaz, C, Ĺopez-Silvarrey Varela, A, Morales-Suárez-Varela, MM, Al-Rawas, O, Mohammad, S, Mohammad, Y, Huang, JL, Kao, CC, Trakultivakorn, M, Vichyanond, P, Lapides, MC, Solé, D, Sears, M, Aguirre, V, Shah, J, Baratawidjaja, K, Nishima, S, de Bruyne, J, Lee, BW & Holgado, D 2014, 'Birthweight and the risk of atopic diseases: The ISAAC Phase III study', Pediatric Allergy and Immunology, vol. 25, no. 3, pp. 264-270. https://doi.org/10.1111/pai.12210
Mitchell EA, Clayton T, García-Marcos L, Pearce N, Foliaki S, Wong G et al. Birthweight and the risk of atopic diseases: The ISAAC Phase III study. Pediatric Allergy and Immunology. 2014;25(3):264-270. https://doi.org/10.1111/pai.12210
Mitchell, Edwin A. ; Clayton, Tadd ; García-Marcos, Luis ; Pearce, Neil ; Foliaki, Sunia ; Wong, Gary ; Aït-Khaled, N. ; Anderson, H. R. ; Asher, M. I. ; Beasley, R. ; Björkstén, B. ; Brunekreef, B. ; Crane, J. ; Ellwood, P. ; Flohr, C. ; Foliaki, S. ; Forastiere, F. ; Garciáa-Marcos, L. ; Keil, U. ; Lai, C. K W ; Mallol, J. ; Mitchell, E. A. ; Montefort, S. ; Odhiambo, J. ; Pearce, N. ; Robertson, C. F. ; Stewart, A. W. ; Strachan, D. ; von Mutius, E. ; Weiland, S. K. ; Weinmayr, G. ; Williams, H. ; Wong, G. ; Asher, M. I. ; Clayton, T. O. ; Ellwood, E. ; Ellwood, P. ; Mitchell, E. A. ; Stewart, A. W. ; de Freitas Souza, L. ; Rennie, D. ; Aguilar, P. ; Amarales, L. ; Aristizábal, G. ; Cepeda, A. M. ; Riikjärv, M. A. ; Zsigmond, G. ; Mantri, S. N. ; Pherwani, A. V. ; Rego, S. ; Salvi, S. ; Sharma, S. K. ; Sukumaran, T. U. ; Suresh Babu, P. S. ; Kartasasmita, C. B. ; Masjedi, M. R. ; Steriu, A. ; Odajima, H. ; Imanalieva, C. ; Kudzyte, J. ; Quah, B. S. ; Teh, K. H. ; Baeza-Bacab, M. ; Barragán-Meijueiro, M. ; Del-Río-Navarro, B. E. ; García-Almaráz, R. ; González-Díaz, S. N. ; Linares-Zapién, F. J. ; Merida-Palacio, J. V. ; Asher, M. I. ; MacKay, R. ; Moyes, C. ; Pattemore, P. ; Brêborowicz, A. ; Lis, G. ; Câmara, R. ; AL-Rawas, Omar ; Nunes, C. ; Rosado Pinto, J. E. ; Goh, D. Y T ; Lee, H. B. ; Busquets, R. M. ; Carvajal-Urueña, I. ; García-Hernández, G. ; García-Marcos, L. ; González Diáaz, C. ; Ĺopez-Silvarrey Varela, A. ; Morales-Suárez-Varela, M. M. ; Al-Rawas, O. ; Mohammad, S. ; Mohammad, Y. ; Huang, J. L. ; Kao, C. C. ; Trakultivakorn, M. ; Vichyanond, P. ; Lapides, M. C. ; Solé, Dirceu ; Sears, Malcolm ; Aguirre, Vivianna ; Shah, Jayant ; Baratawidjaja, Karnen ; Nishima, Sankei ; de Bruyne, Jessie ; Lee, Bee Wah ; Holgado, Dolores. / Birthweight and the risk of atopic diseases : The ISAAC Phase III study. In: Pediatric Allergy and Immunology. 2014 ; Vol. 25, No. 3. pp. 264-270.
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abstract = "Background: The association between birthweight and asthma, eczema and rhinoconjunctivitis is conflicting. Aims: To examine the association between birthweight and symptoms of asthma, eczema and rhinoconjunctivitis. Methods: Parents or guardians of children aged 6-7 yr completed written questionnaires about symptoms of asthma, rhinoconjunctivitis and eczema, and several risk factors, including birthweight. Results: There were 162,324 children from 60 centres in 26 countries. Low birthweight (<2.5 kg) was associated with an increased risk of symptoms of asthma (current wheeze odds ratio = 1.20; 95{\%} confidence interval = 1.12-1.30). Low birthweight was associated with a lower risk of eczema ever. Low birthweight was not associated with rhinoconjunctivitis. Large babies (birthweight ≥4.5 kg) were not associated with any of these outcomes. Conclusions: This study has confirmed that low birthweight is a risk factor for symptoms of asthma, but not for rhinoconjunctivitis. The findings for eczema are equivocal.",
keywords = "Asthma, Eczema, ISAAC, Low birthweight, Rhinoconjunctivitis, Risk factors",
author = "Mitchell, {Edwin A.} and Tadd Clayton and Luis Garc{\'i}a-Marcos and Neil Pearce and Sunia Foliaki and Gary Wong and N. A{\"i}t-Khaled and Anderson, {H. R.} and Asher, {M. I.} and R. Beasley and B. Bj{\"o}rkst{\'e}n and B. Brunekreef and J. Crane and P. Ellwood and C. Flohr and S. Foliaki and F. Forastiere and L. Garci{\'a}a-Marcos and U. Keil and Lai, {C. K W} and J. Mallol and Mitchell, {E. A.} and S. Montefort and J. Odhiambo and N. Pearce and Robertson, {C. F.} and Stewart, {A. W.} and D. Strachan and {von Mutius}, E. and Weiland, {S. K.} and G. Weinmayr and H. Williams and G. Wong and Asher, {M. I.} and Clayton, {T. O.} and E. Ellwood and P. Ellwood and Mitchell, {E. A.} and Stewart, {A. W.} and {de Freitas Souza}, L. and D. Rennie and P. Aguilar and L. Amarales and G. Aristiz{\'a}bal and Cepeda, {A. M.} and Riikj{\"a}rv, {M. A.} and G. Zsigmond and Mantri, {S. N.} and Pherwani, {A. V.} and S. Rego and S. Salvi and Sharma, {S. K.} and Sukumaran, {T. U.} and {Suresh Babu}, {P. S.} and Kartasasmita, {C. B.} and Masjedi, {M. R.} and A. Steriu and H. Odajima and C. Imanalieva and J. Kudzyte and Quah, {B. S.} and Teh, {K. H.} and M. Baeza-Bacab and M. Barrag{\'a}n-Meijueiro and Del-R{\'i}o-Navarro, {B. E.} and R. Garc{\'i}a-Almar{\'a}z and Gonz{\'a}lez-D{\'i}az, {S. N.} and Linares-Zapi{\'e}n, {F. J.} and Merida-Palacio, {J. V.} and Asher, {M. I.} and R. MacKay and C. Moyes and P. Pattemore and A. Br{\^e}borowicz and G. Lis and R. C{\^a}mara and Omar AL-Rawas and C. Nunes and {Rosado Pinto}, {J. E.} and Goh, {D. Y T} and Lee, {H. B.} and Busquets, {R. M.} and I. Carvajal-Urue{\~n}a and G. Garc{\'i}a-Hern{\'a}ndez and L. Garc{\'i}a-Marcos and {Gonz{\'a}lez Di{\'a}az}, C. and {Ĺopez-Silvarrey Varela}, A. and Morales-Su{\'a}rez-Varela, {M. M.} and O. Al-Rawas and S. Mohammad and Y. Mohammad and Huang, {J. L.} and Kao, {C. C.} and M. Trakultivakorn and P. Vichyanond and Lapides, {M. C.} and Dirceu Sol{\'e} and Malcolm Sears and Vivianna Aguirre and Jayant Shah and Karnen Baratawidjaja and Sankei Nishima and {de Bruyne}, Jessie and Lee, {Bee Wah} and Dolores Holgado",
year = "2014",
doi = "10.1111/pai.12210",
language = "English",
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pages = "264--270",
journal = "Pediatric Allergy and Immunology",
issn = "0905-6157",
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TY - JOUR

T1 - Birthweight and the risk of atopic diseases

T2 - The ISAAC Phase III study

AU - Mitchell, Edwin A.

AU - Clayton, Tadd

AU - García-Marcos, Luis

AU - Pearce, Neil

AU - Foliaki, Sunia

AU - Wong, Gary

AU - Aït-Khaled, N.

AU - Anderson, H. R.

AU - Asher, M. I.

AU - Beasley, R.

AU - Björkstén, B.

AU - Brunekreef, B.

AU - Crane, J.

AU - Ellwood, P.

AU - Flohr, C.

AU - Foliaki, S.

AU - Forastiere, F.

AU - Garciáa-Marcos, L.

AU - Keil, U.

AU - Lai, C. K W

AU - Mallol, J.

AU - Mitchell, E. A.

AU - Montefort, S.

AU - Odhiambo, J.

AU - Pearce, N.

AU - Robertson, C. F.

AU - Stewart, A. W.

AU - Strachan, D.

AU - von Mutius, E.

AU - Weiland, S. K.

AU - Weinmayr, G.

AU - Williams, H.

AU - Wong, G.

AU - Asher, M. I.

AU - Clayton, T. O.

AU - Ellwood, E.

AU - Ellwood, P.

AU - Mitchell, E. A.

AU - Stewart, A. W.

AU - de Freitas Souza, L.

AU - Rennie, D.

AU - Aguilar, P.

AU - Amarales, L.

AU - Aristizábal, G.

AU - Cepeda, A. M.

AU - Riikjärv, M. A.

AU - Zsigmond, G.

AU - Mantri, S. N.

AU - Pherwani, A. V.

AU - Rego, S.

AU - Salvi, S.

AU - Sharma, S. K.

AU - Sukumaran, T. U.

AU - Suresh Babu, P. S.

AU - Kartasasmita, C. B.

AU - Masjedi, M. R.

AU - Steriu, A.

AU - Odajima, H.

AU - Imanalieva, C.

AU - Kudzyte, J.

AU - Quah, B. S.

AU - Teh, K. H.

AU - Baeza-Bacab, M.

AU - Barragán-Meijueiro, M.

AU - Del-Río-Navarro, B. E.

AU - García-Almaráz, R.

AU - González-Díaz, S. N.

AU - Linares-Zapién, F. J.

AU - Merida-Palacio, J. V.

AU - Asher, M. I.

AU - MacKay, R.

AU - Moyes, C.

AU - Pattemore, P.

AU - Brêborowicz, A.

AU - Lis, G.

AU - Câmara, R.

AU - AL-Rawas, Omar

AU - Nunes, C.

AU - Rosado Pinto, J. E.

AU - Goh, D. Y T

AU - Lee, H. B.

AU - Busquets, R. M.

AU - Carvajal-Urueña, I.

AU - García-Hernández, G.

AU - García-Marcos, L.

AU - González Diáaz, C.

AU - Ĺopez-Silvarrey Varela, A.

AU - Morales-Suárez-Varela, M. M.

AU - Al-Rawas, O.

AU - Mohammad, S.

AU - Mohammad, Y.

AU - Huang, J. L.

AU - Kao, C. C.

AU - Trakultivakorn, M.

AU - Vichyanond, P.

AU - Lapides, M. C.

AU - Solé, Dirceu

AU - Sears, Malcolm

AU - Aguirre, Vivianna

AU - Shah, Jayant

AU - Baratawidjaja, Karnen

AU - Nishima, Sankei

AU - de Bruyne, Jessie

AU - Lee, Bee Wah

AU - Holgado, Dolores

PY - 2014

Y1 - 2014

N2 - Background: The association between birthweight and asthma, eczema and rhinoconjunctivitis is conflicting. Aims: To examine the association between birthweight and symptoms of asthma, eczema and rhinoconjunctivitis. Methods: Parents or guardians of children aged 6-7 yr completed written questionnaires about symptoms of asthma, rhinoconjunctivitis and eczema, and several risk factors, including birthweight. Results: There were 162,324 children from 60 centres in 26 countries. Low birthweight (<2.5 kg) was associated with an increased risk of symptoms of asthma (current wheeze odds ratio = 1.20; 95% confidence interval = 1.12-1.30). Low birthweight was associated with a lower risk of eczema ever. Low birthweight was not associated with rhinoconjunctivitis. Large babies (birthweight ≥4.5 kg) were not associated with any of these outcomes. Conclusions: This study has confirmed that low birthweight is a risk factor for symptoms of asthma, but not for rhinoconjunctivitis. The findings for eczema are equivocal.

AB - Background: The association between birthweight and asthma, eczema and rhinoconjunctivitis is conflicting. Aims: To examine the association between birthweight and symptoms of asthma, eczema and rhinoconjunctivitis. Methods: Parents or guardians of children aged 6-7 yr completed written questionnaires about symptoms of asthma, rhinoconjunctivitis and eczema, and several risk factors, including birthweight. Results: There were 162,324 children from 60 centres in 26 countries. Low birthweight (<2.5 kg) was associated with an increased risk of symptoms of asthma (current wheeze odds ratio = 1.20; 95% confidence interval = 1.12-1.30). Low birthweight was associated with a lower risk of eczema ever. Low birthweight was not associated with rhinoconjunctivitis. Large babies (birthweight ≥4.5 kg) were not associated with any of these outcomes. Conclusions: This study has confirmed that low birthweight is a risk factor for symptoms of asthma, but not for rhinoconjunctivitis. The findings for eczema are equivocal.

KW - Asthma

KW - Eczema

KW - ISAAC

KW - Low birthweight

KW - Rhinoconjunctivitis

KW - Risk factors

UR - http://www.scopus.com/inward/record.url?scp=84898833349&partnerID=8YFLogxK

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U2 - 10.1111/pai.12210

DO - 10.1111/pai.12210

M3 - Article

VL - 25

SP - 264

EP - 270

JO - Pediatric Allergy and Immunology

JF - Pediatric Allergy and Immunology

SN - 0905-6157

IS - 3

ER -