Bioactive ent-kaurene diterpenoids from Annona senegalensis

Majekodunmi O. Fatope, Oladimeji T. Audu, Yoshio Takeda, Lu Zeng, Guoen Shi, Hiroko Shimada, Jerry L. McLaughlin

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1-4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED50 1.0 μg/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED50 17-18 μg/mL). The structure of the new compound, 3, was deduced from spectral evidence.

Original languageEnglish
Pages (from-to)301-303
Number of pages3
JournalJournal of Natural Products
Volume59
Issue number3
DOIs
Publication statusPublished - Mar 1996

Fingerprint

Annona senegalensis
Kaurane Diterpenes
Annona
Diterpenes
Cytotoxicity
Fractionation
diterpenoids
prostatic neoplasms
breast neoplasms
cytotoxicity
Prostatic Neoplasms
fractionation
bark
Breast Neoplasms
stems
neoplasm cells

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Fatope, M. O., Audu, O. T., Takeda, Y., Zeng, L., Shi, G., Shimada, H., & McLaughlin, J. L. (1996). Bioactive ent-kaurene diterpenoids from Annona senegalensis. Journal of Natural Products, 59(3), 301-303. https://doi.org/10.1021/np9601566

Bioactive ent-kaurene diterpenoids from Annona senegalensis. / Fatope, Majekodunmi O.; Audu, Oladimeji T.; Takeda, Yoshio; Zeng, Lu; Shi, Guoen; Shimada, Hiroko; McLaughlin, Jerry L.

In: Journal of Natural Products, Vol. 59, No. 3, 03.1996, p. 301-303.

Research output: Contribution to journalArticle

Fatope, MO, Audu, OT, Takeda, Y, Zeng, L, Shi, G, Shimada, H & McLaughlin, JL 1996, 'Bioactive ent-kaurene diterpenoids from Annona senegalensis', Journal of Natural Products, vol. 59, no. 3, pp. 301-303. https://doi.org/10.1021/np9601566
Fatope, Majekodunmi O. ; Audu, Oladimeji T. ; Takeda, Yoshio ; Zeng, Lu ; Shi, Guoen ; Shimada, Hiroko ; McLaughlin, Jerry L. / Bioactive ent-kaurene diterpenoids from Annona senegalensis. In: Journal of Natural Products. 1996 ; Vol. 59, No. 3. pp. 301-303.
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