Bioactive ent-kaurene diterpenoids from Annona senegalensis

Majekodunmi O. Fatope, Oladimeji T. Audu, Yoshio Takeda, Lu Zeng, Guoen Shi, Hiroko Shimada, Jerry L. McLaughlin

Research output: Contribution to journalArticle

44 Citations (Scopus)


Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1-4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED50 1.0 μg/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED50 17-18 μg/mL). The structure of the new compound, 3, was deduced from spectral evidence.

Original languageEnglish
Pages (from-to)301-303
Number of pages3
JournalJournal of Natural Products
Issue number3
Publication statusPublished - Mar 1996

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

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  • Cite this

    Fatope, M. O., Audu, O. T., Takeda, Y., Zeng, L., Shi, G., Shimada, H., & McLaughlin, J. L. (1996). Bioactive ent-kaurene diterpenoids from Annona senegalensis. Journal of Natural Products, 59(3), 301-303.