Bioactive ent-kaurene diterpenoids from Annona senegalensis

Majekodunmi O. Fatope; Oladimeji T. Audu; Yoshio Takeda; Lu Zeng; Guoen Shi; Hiroko Shimada; Jerry L. McLaughlin

doi:10.1021/np9601566

Bioactive ent-kaurene diterpenoids from Annona senegalensis

Majekodunmi O. Fatope, Oladimeji T. Audu, Yoshio Takeda, Lu Zeng, Guoen Shi, Hiroko Shimada, Jerry L. McLaughlin

Chemistry

Research output: Contribution to journal › Article

43 Citations (Scopus)

Abstract

Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1-4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED₅₀ 1.0 μg/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED₅₀ 17-18 μg/mL). The structure of the new compound, 3, was deduced from spectral evidence.

Original language	English
Pages (from-to)	301-303
Number of pages	3
Journal	Journal of Natural Products
Volume	59
Issue number	3
DOIs	https://doi.org/10.1021/np9601566
Publication status	Published - Mar 1996

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ASJC Scopus subject areas

Plant Science
Chemistry (miscellaneous)
Organic Chemistry
Drug Discovery
Pharmacology

Cite this

Fatope, M. O., Audu, O. T., Takeda, Y., Zeng, L., Shi, G., Shimada, H., & McLaughlin, J. L. (1996). Bioactive ent-kaurene diterpenoids from Annona senegalensis. Journal of Natural Products, 59(3), 301-303. https://doi.org/10.1021/np9601566

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10.1021/np9601566