Bioactive ent-kaurene diterpenoids from Annona senegalensis

Majekodunmi O. Fatope; Oladimeji T. Audu; Yoshio Takeda; Lu Zeng; Guoen Shi; Hiroko Shimada; Jerry L. McLaughlin

doi:10.1021/np9601566

Bioactive ent-kaurene diterpenoids from Annona senegalensis

Majekodunmi O. Fatope, Oladimeji T. Audu, Yoshio Takeda, Lu Zeng, Guoen Shi, Hiroko Shimada, Jerry L. McLaughlin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1-4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED₅₀ 1.0 μg/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED₅₀ 17-18 μg/mL). The structure of the new compound, 3, was deduced from spectral evidence.

Original language	English
Pages (from-to)	301-303
Number of pages	3
Journal	Journal of Natural Products
Volume	59
Issue number	3
DOIs	https://doi.org/10.1021/np9601566
Publication status	Published - Mar 1996
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/np9601566

Cite this

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title = "Bioactive ent-kaurene diterpenoids from Annona senegalensis",

abstract = "Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1-4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED50 1.0 μg/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED50 17-18 μg/mL). The structure of the new compound, 3, was deduced from spectral evidence.",

author = "Fatope, {Majekodunmi O.} and Audu, {Oladimeji T.} and Yoshio Takeda and Lu Zeng and Guoen Shi and Hiroko Shimada and McLaughlin, {Jerry L.}",

year = "1996",

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doi = "10.1021/np9601566",

language = "English",

volume = "59",

pages = "301--303",

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AU - Fatope, Majekodunmi O.

AU - Audu, Oladimeji T.

AU - Takeda, Yoshio

AU - Zeng, Lu

AU - Shi, Guoen

AU - Shimada, Hiroko

AU - McLaughlin, Jerry L.

PY - 1996/3

Y1 - 1996/3

N2 - Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1-4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED50 1.0 μg/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED50 17-18 μg/mL). The structure of the new compound, 3, was deduced from spectral evidence.

AB - Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1-4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED50 1.0 μg/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED50 17-18 μg/mL). The structure of the new compound, 3, was deduced from spectral evidence.

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JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 3

ER -

Bioactive ent-kaurene diterpenoids from Annona senegalensis

Abstract

ASJC Scopus subject areas

UN SDGs

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