Bioactive ent-kaurene diterpenoids from Annona senegalensis

Majekodunmi O. Fatope; Oladimeji T. Audu; Yoshio Takeda; Lu Zeng; Guoen Shi; Hiroko Shimada; Jerry L. McLaughlin

doi:10.1021/np9601566

Bioactive ent-kaurene diterpenoids from Annona senegalensis

Majekodunmi O. Fatope, Oladimeji T. Audu, Yoshio Takeda, Lu Zeng, Guoen Shi, Hiroko Shimada, Jerry L. McLaughlin^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1-4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED₅₀ 1.0 μg/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED₅₀ 17-18 μg/mL). The structure of the new compound, 3, was deduced from spectral evidence.

Original language	English
Pages (from-to)	301-303
Number of pages	3
Journal	Journal of Natural Products
Volume	59
Issue number	3
DOIs	https://doi.org/10.1021/np9601566
Publication status	Published - Mar 1996

ASJC Scopus subject areas

Plant Science
Chemistry (miscellaneous)
Organic Chemistry
Drug Discovery
Pharmacology

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AU - Fatope, Majekodunmi O.

AU - Audu, Oladimeji T.

AU - Takeda, Yoshio

AU - Zeng, Lu

AU - Shi, Guoen

AU - Shimada, Hiroko

AU - McLaughlin, Jerry L.

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AB - Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1-4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED50 1.0 μg/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED50 17-18 μg/mL). The structure of the new compound, 3, was deduced from spectral evidence.

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