Bioactive ent-kaurene diterpenoids from Annona senegalensis

Majekodunmi O. Fatope, Oladimeji T. Audu, Yoshio Takeda, Lu Zeng, Guoen Shi, Hiroko Shimada, Jerry L. McLaughlin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1-4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED50 1.0 μg/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED50 17-18 μg/mL). The structure of the new compound, 3, was deduced from spectral evidence.

Original languageEnglish
Pages (from-to)301-303
Number of pages3
JournalJournal of Natural Products
Volume59
Issue number3
DOIs
Publication statusPublished - Mar 1996

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Fingerprint Dive into the research topics of 'Bioactive ent-kaurene diterpenoids from Annona senegalensis'. Together they form a unique fingerprint.

Cite this