TY - JOUR
T1 - Bioactive ent-kaurene diterpenoids from Annona senegalensis
AU - Fatope, Majekodunmi O.
AU - Audu, Oladimeji T.
AU - Takeda, Yoshio
AU - Zeng, Lu
AU - Shi, Guoen
AU - Shimada, Hiroko
AU - McLaughlin, Jerry L.
PY - 1996/3
Y1 - 1996/3
N2 - Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1-4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED50 1.0 μg/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED50 17-18 μg/mL). The structure of the new compound, 3, was deduced from spectral evidence.
AB - Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1-4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED50 1.0 μg/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED50 17-18 μg/mL). The structure of the new compound, 3, was deduced from spectral evidence.
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U2 - 10.1021/np9601566
DO - 10.1021/np9601566
M3 - Article
C2 - 8882434
AN - SCOPUS:0030012201
VL - 59
SP - 301
EP - 303
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 3
ER -