Abstract
Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1-4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED50 1.0 μg/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED50 17-18 μg/mL). The structure of the new compound, 3, was deduced from spectral evidence.
| Original language | English |
|---|---|
| Pages (from-to) | 301-303 |
| Number of pages | 3 |
| Journal | Journal of Natural Products |
| Volume | 59 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 1996 |
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ASJC Scopus subject areas
- Plant Science
- Chemistry (miscellaneous)
- Organic Chemistry
- Drug Discovery
- Pharmacology
Cite this
Bioactive ent-kaurene diterpenoids from Annona senegalensis. / Fatope, Majekodunmi O.; Audu, Oladimeji T.; Takeda, Yoshio; Zeng, Lu; Shi, Guoen; Shimada, Hiroko; McLaughlin, Jerry L.
In: Journal of Natural Products, Vol. 59, No. 3, 03.1996, p. 301-303.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bioactive ent-kaurene diterpenoids from Annona senegalensis
AU - Fatope, Majekodunmi O.
AU - Audu, Oladimeji T.
AU - Takeda, Yoshio
AU - Zeng, Lu
AU - Shi, Guoen
AU - Shimada, Hiroko
AU - McLaughlin, Jerry L.
PY - 1996/3
Y1 - 1996/3
N2 - Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1-4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED50 1.0 μg/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED50 17-18 μg/mL). The structure of the new compound, 3, was deduced from spectral evidence.
AB - Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1-4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED50 1.0 μg/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED50 17-18 μg/mL). The structure of the new compound, 3, was deduced from spectral evidence.
UR - http://www.scopus.com/inward/record.url?scp=0030012201&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030012201&partnerID=8YFLogxK
U2 - 10.1021/np9601566
DO - 10.1021/np9601566
M3 - Article
C2 - 8882434
AN - SCOPUS:0030012201
VL - 59
SP - 301
EP - 303
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 3
ER -