Beneficial effect of Cissus quadrangularis linn. on osteopenia associated with streptozotocin-induced type 1 diabetes mellitus in male Wistar rats

Srinivasa Rao Sirasanagandla, Sreedhara Ranganath Pai Karkala, Bhagath Kumar Potu, Kumar M.R. Bhat

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Petroleum ether fraction of Cissus quadrangularis (PECQ) impact on the development of osteopenia in type 1 diabetic rat model has been evaluated. Diabetic rats were treated orally with two doses of PECQ. Another group of diabetic rats were treated with subcutaneous injection of synthetic human insulin. The cortical and trabecular bone thickness and bone strength were significantly decreased in diabetic rats. Treatment with two doses of PECQ significantly prevented these changes in diabetic rats. However, PECQ treatment (two doses) did not alter the glycemic levels in these diabetic rats. Increased levels of serum alkaline phosphatase (ALP), tartrate-resistant acid phosphatase (TRAP), and hydroxyproline were noted in diabetic rats when compared to normal control rats. The two doses of PECQ treatment further improved the serum ALP levels and significantly decreased the serum levels of TRAP and hydroxyproline. The effects of PECQ treatment on histological, biomechanical, and biochemical parameters are comparable to those of insulin. Since PECQ improves the bone health in hyperglycemic conditions by enhancing the cortical and trabecular bone growth and altering the circulating bone markers, it could be used as an effective therapy against diabetes-associated bone disorders.

Original languageEnglish
Article number483051
JournalAdvances in Pharmacological Sciences
Volume2014
DOIs
Publication statusPublished - 2014

Fingerprint

Cissus
Metabolic Bone Diseases
Streptozocin
Type 1 Diabetes Mellitus
Wistar Rats
Bone and Bones
Hydroxyproline
Alkaline Phosphatase
Serum
Insulin
Therapeutics
Bone Development
Subcutaneous Injections
naphtha

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Cite this

Beneficial effect of Cissus quadrangularis linn. on osteopenia associated with streptozotocin-induced type 1 diabetes mellitus in male Wistar rats. / Rao Sirasanagandla, Srinivasa; Ranganath Pai Karkala, Sreedhara; Potu, Bhagath Kumar; Bhat, Kumar M.R.

In: Advances in Pharmacological Sciences, Vol. 2014, 483051, 2014.

Research output: Contribution to journalArticle

@article{9d485aac01cb4de3ae86b28c67b25c07,
title = "Beneficial effect of Cissus quadrangularis linn. on osteopenia associated with streptozotocin-induced type 1 diabetes mellitus in male Wistar rats",
abstract = "Petroleum ether fraction of Cissus quadrangularis (PECQ) impact on the development of osteopenia in type 1 diabetic rat model has been evaluated. Diabetic rats were treated orally with two doses of PECQ. Another group of diabetic rats were treated with subcutaneous injection of synthetic human insulin. The cortical and trabecular bone thickness and bone strength were significantly decreased in diabetic rats. Treatment with two doses of PECQ significantly prevented these changes in diabetic rats. However, PECQ treatment (two doses) did not alter the glycemic levels in these diabetic rats. Increased levels of serum alkaline phosphatase (ALP), tartrate-resistant acid phosphatase (TRAP), and hydroxyproline were noted in diabetic rats when compared to normal control rats. The two doses of PECQ treatment further improved the serum ALP levels and significantly decreased the serum levels of TRAP and hydroxyproline. The effects of PECQ treatment on histological, biomechanical, and biochemical parameters are comparable to those of insulin. Since PECQ improves the bone health in hyperglycemic conditions by enhancing the cortical and trabecular bone growth and altering the circulating bone markers, it could be used as an effective therapy against diabetes-associated bone disorders.",
author = "{Rao Sirasanagandla}, Srinivasa and {Ranganath Pai Karkala}, Sreedhara and Potu, {Bhagath Kumar} and Bhat, {Kumar M.R.}",
year = "2014",
doi = "10.1155/2014/483051",
language = "English",
volume = "2014",
journal = "Advances in Pharmacological Sciences",
issn = "1687-6334",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Beneficial effect of Cissus quadrangularis linn. on osteopenia associated with streptozotocin-induced type 1 diabetes mellitus in male Wistar rats

AU - Rao Sirasanagandla, Srinivasa

AU - Ranganath Pai Karkala, Sreedhara

AU - Potu, Bhagath Kumar

AU - Bhat, Kumar M.R.

PY - 2014

Y1 - 2014

N2 - Petroleum ether fraction of Cissus quadrangularis (PECQ) impact on the development of osteopenia in type 1 diabetic rat model has been evaluated. Diabetic rats were treated orally with two doses of PECQ. Another group of diabetic rats were treated with subcutaneous injection of synthetic human insulin. The cortical and trabecular bone thickness and bone strength were significantly decreased in diabetic rats. Treatment with two doses of PECQ significantly prevented these changes in diabetic rats. However, PECQ treatment (two doses) did not alter the glycemic levels in these diabetic rats. Increased levels of serum alkaline phosphatase (ALP), tartrate-resistant acid phosphatase (TRAP), and hydroxyproline were noted in diabetic rats when compared to normal control rats. The two doses of PECQ treatment further improved the serum ALP levels and significantly decreased the serum levels of TRAP and hydroxyproline. The effects of PECQ treatment on histological, biomechanical, and biochemical parameters are comparable to those of insulin. Since PECQ improves the bone health in hyperglycemic conditions by enhancing the cortical and trabecular bone growth and altering the circulating bone markers, it could be used as an effective therapy against diabetes-associated bone disorders.

AB - Petroleum ether fraction of Cissus quadrangularis (PECQ) impact on the development of osteopenia in type 1 diabetic rat model has been evaluated. Diabetic rats were treated orally with two doses of PECQ. Another group of diabetic rats were treated with subcutaneous injection of synthetic human insulin. The cortical and trabecular bone thickness and bone strength were significantly decreased in diabetic rats. Treatment with two doses of PECQ significantly prevented these changes in diabetic rats. However, PECQ treatment (two doses) did not alter the glycemic levels in these diabetic rats. Increased levels of serum alkaline phosphatase (ALP), tartrate-resistant acid phosphatase (TRAP), and hydroxyproline were noted in diabetic rats when compared to normal control rats. The two doses of PECQ treatment further improved the serum ALP levels and significantly decreased the serum levels of TRAP and hydroxyproline. The effects of PECQ treatment on histological, biomechanical, and biochemical parameters are comparable to those of insulin. Since PECQ improves the bone health in hyperglycemic conditions by enhancing the cortical and trabecular bone growth and altering the circulating bone markers, it could be used as an effective therapy against diabetes-associated bone disorders.

UR - http://www.scopus.com/inward/record.url?scp=84899975456&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899975456&partnerID=8YFLogxK

U2 - 10.1155/2014/483051

DO - 10.1155/2014/483051

M3 - Article

VL - 2014

JO - Advances in Pharmacological Sciences

JF - Advances in Pharmacological Sciences

SN - 1687-6334

M1 - 483051

ER -