Autoimmune haemolytic anaemia as the presenting manifestation of agnogenic myeloid metaplasia

Unmesh Mohite, Anil Pathare*, Salam Al Kindi, Devendra Hiwase, Nirmala Vadakkepat, Huxley Knox-Macaulay

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We report an unusual case of a 40-year-old female patient with a severe case of direct Coombs positive haemolytic anaemia, moderate hepatomegaly and marked splenomegaly. Her initial response to steroids was transient and was rapidly followed by a relapse. Therefore, she underwent splenectomy both as a therapeutic measure and to rule out an underlying lymphoproliferative disorder. Histopathological examination of the excised spleen, as well a liver biopsy, revealed extensive extramedullary haematopoiesis, while significant marrow fibrosis was noted in a trephine biopsy sample. These findings confirmed the concomitant diagnosis of agnogenic myeloid metaplasia with myelofibrosis.

Original languageEnglish
Pages (from-to)495-499
Number of pages5
Issue number4
Publication statusPublished - 2002
Externally publishedYes

ASJC Scopus subject areas

  • Hematology


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