Autoimmune haemolytic anaemia as the presenting manifestation of agnogenic myeloid metaplasia

Unmesh Mohite, Anil Pathare, Salam Al Kindi, Devendra Hiwase, Nirmala Vadakkepat, Huxley Knox-Macaulay

Research output: Contribution to journalArticle

Abstract

We report an unusual case of a 40-year-old female patient with a severe case of direct Coombs positive haemolytic anaemia, moderate hepatomegaly and marked splenomegaly. Her initial response to steroids was transient and was rapidly followed by a relapse. Therefore, she underwent splenectomy both as a therapeutic measure and to rule out an underlying lymphoproliferative disorder. Histopathological examination of the excised spleen, as well a liver biopsy, revealed extensive extramedullary haematopoiesis, while significant marrow fibrosis was noted in a trephine biopsy sample. These findings confirmed the concomitant diagnosis of agnogenic myeloid metaplasia with myelofibrosis.

Original languageEnglish
Pages (from-to)495-499
Number of pages5
JournalHaematologia
Volume32
Issue number4
Publication statusPublished - 2002

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Autoimmune Hemolytic Anemia
Primary Myelofibrosis
Extramedullary Hematopoiesis
Biopsy
Hepatomegaly
Lymphoproliferative Disorders
Hemolytic Anemia
Splenomegaly
Splenectomy
Fibrosis
Spleen
Bone Marrow
Steroids
Recurrence
Liver
Therapeutics

ASJC Scopus subject areas

  • Hematology

Cite this

Mohite, U., Pathare, A., Al Kindi, S., Hiwase, D., Vadakkepat, N., & Knox-Macaulay, H. (2002). Autoimmune haemolytic anaemia as the presenting manifestation of agnogenic myeloid metaplasia. Haematologia, 32(4), 495-499.

Autoimmune haemolytic anaemia as the presenting manifestation of agnogenic myeloid metaplasia. / Mohite, Unmesh; Pathare, Anil; Al Kindi, Salam; Hiwase, Devendra; Vadakkepat, Nirmala; Knox-Macaulay, Huxley.

In: Haematologia, Vol. 32, No. 4, 2002, p. 495-499.

Research output: Contribution to journalArticle

Mohite, U, Pathare, A, Al Kindi, S, Hiwase, D, Vadakkepat, N & Knox-Macaulay, H 2002, 'Autoimmune haemolytic anaemia as the presenting manifestation of agnogenic myeloid metaplasia', Haematologia, vol. 32, no. 4, pp. 495-499.
Mohite, Unmesh ; Pathare, Anil ; Al Kindi, Salam ; Hiwase, Devendra ; Vadakkepat, Nirmala ; Knox-Macaulay, Huxley. / Autoimmune haemolytic anaemia as the presenting manifestation of agnogenic myeloid metaplasia. In: Haematologia. 2002 ; Vol. 32, No. 4. pp. 495-499.
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