Association of the A561C E-selectin polymorphism with systemic lupus erythematosus in 2 independent populations

M. El-Magadmi, A. Alansari, L. S. Teh, J. Ordi, A. Gül, M. Inanc, I. Bruce, A. Hajeer

Research output: Contribution to journalArticle

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Abstract

Objective. E-selectin is expressed on cytokine stimulated endothelial cells and plays an important role in leukocyte-endothelium interactions and inflammatory cell recruitment. The gene for E-selectin is located at chromosome 1q 23-25 within the linkage area for systemic lupus erythematosus (SLE). The best characterized polymorphism in E-selectin molecule is A561C, which codes for Ser128Arg. We studied the prevalence of the A561C E-selectin gene polymorphism in patients with SLE and controls from 3 different ethnic populations. Methods. Three cohorts of patients with SLE (1987 American College of Rheumatology criteria) and matching population controls were studied. These consisted of Caucasians of British Isles descent, Caucasians of Spanish origin, and Caucasians of Turkish origin. We used polymerase chain reaction and restriction fragment length polymorphism to genotype patients and controls. Results. The numbers of patients and controls in each group were: UK (113 and 148), Spanish (145 and 179), and Turkish (93 and 96), respectively. The C allele occurred more frequently in UK and Spanish patients (OR 1.76, 95% CI 1.03-3.0, p = 0.037; and OR 1.84, 95% CI 1.1-3.09, p = 0.019), but not in Turkish patients (OR 1.03, 95% CI 0.55-1.97, p = 0.91). Conclusion. In 2 of 3 populations studied, the E-selectin C allele was significantly more common in SLE than in controls, E-selectin may be a susceptibility gene to SLE in these populations. Its role in disease expression and longterm outcomes such as accelerated atherosclerosis requires further study.

Original languageEnglish
Pages (from-to)2650-2652
Number of pages3
JournalJournal of Rheumatology
Volume28
Issue number12
Publication statusPublished - 2001

Fingerprint

E-Selectin
Systemic Lupus Erythematosus
Population
Alleles
Genes
Population Control
Cell Communication
Restriction Fragment Length Polymorphisms
Endothelium
Atherosclerosis
Leukocytes
Endothelial Cells
Chromosomes
Genotype
Cytokines
Polymerase Chain Reaction

Keywords

  • Association studies
  • E-selectin
  • Ethnicity
  • Genetics
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

El-Magadmi, M., Alansari, A., Teh, L. S., Ordi, J., Gül, A., Inanc, M., ... Hajeer, A. (2001). Association of the A561C E-selectin polymorphism with systemic lupus erythematosus in 2 independent populations. Journal of Rheumatology, 28(12), 2650-2652.

Association of the A561C E-selectin polymorphism with systemic lupus erythematosus in 2 independent populations. / El-Magadmi, M.; Alansari, A.; Teh, L. S.; Ordi, J.; Gül, A.; Inanc, M.; Bruce, I.; Hajeer, A.

In: Journal of Rheumatology, Vol. 28, No. 12, 2001, p. 2650-2652.

Research output: Contribution to journalArticle

El-Magadmi, M, Alansari, A, Teh, LS, Ordi, J, Gül, A, Inanc, M, Bruce, I & Hajeer, A 2001, 'Association of the A561C E-selectin polymorphism with systemic lupus erythematosus in 2 independent populations', Journal of Rheumatology, vol. 28, no. 12, pp. 2650-2652.
El-Magadmi, M. ; Alansari, A. ; Teh, L. S. ; Ordi, J. ; Gül, A. ; Inanc, M. ; Bruce, I. ; Hajeer, A. / Association of the A561C E-selectin polymorphism with systemic lupus erythematosus in 2 independent populations. In: Journal of Rheumatology. 2001 ; Vol. 28, No. 12. pp. 2650-2652.
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abstract = "Objective. E-selectin is expressed on cytokine stimulated endothelial cells and plays an important role in leukocyte-endothelium interactions and inflammatory cell recruitment. The gene for E-selectin is located at chromosome 1q 23-25 within the linkage area for systemic lupus erythematosus (SLE). The best characterized polymorphism in E-selectin molecule is A561C, which codes for Ser128Arg. We studied the prevalence of the A561C E-selectin gene polymorphism in patients with SLE and controls from 3 different ethnic populations. Methods. Three cohorts of patients with SLE (1987 American College of Rheumatology criteria) and matching population controls were studied. These consisted of Caucasians of British Isles descent, Caucasians of Spanish origin, and Caucasians of Turkish origin. We used polymerase chain reaction and restriction fragment length polymorphism to genotype patients and controls. Results. The numbers of patients and controls in each group were: UK (113 and 148), Spanish (145 and 179), and Turkish (93 and 96), respectively. The C allele occurred more frequently in UK and Spanish patients (OR 1.76, 95{\%} CI 1.03-3.0, p = 0.037; and OR 1.84, 95{\%} CI 1.1-3.09, p = 0.019), but not in Turkish patients (OR 1.03, 95{\%} CI 0.55-1.97, p = 0.91). Conclusion. In 2 of 3 populations studied, the E-selectin C allele was significantly more common in SLE than in controls, E-selectin may be a susceptibility gene to SLE in these populations. Its role in disease expression and longterm outcomes such as accelerated atherosclerosis requires further study.",
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AU - El-Magadmi, M.

AU - Alansari, A.

AU - Teh, L. S.

AU - Ordi, J.

AU - Gül, A.

AU - Inanc, M.

AU - Bruce, I.

AU - Hajeer, A.

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N2 - Objective. E-selectin is expressed on cytokine stimulated endothelial cells and plays an important role in leukocyte-endothelium interactions and inflammatory cell recruitment. The gene for E-selectin is located at chromosome 1q 23-25 within the linkage area for systemic lupus erythematosus (SLE). The best characterized polymorphism in E-selectin molecule is A561C, which codes for Ser128Arg. We studied the prevalence of the A561C E-selectin gene polymorphism in patients with SLE and controls from 3 different ethnic populations. Methods. Three cohorts of patients with SLE (1987 American College of Rheumatology criteria) and matching population controls were studied. These consisted of Caucasians of British Isles descent, Caucasians of Spanish origin, and Caucasians of Turkish origin. We used polymerase chain reaction and restriction fragment length polymorphism to genotype patients and controls. Results. The numbers of patients and controls in each group were: UK (113 and 148), Spanish (145 and 179), and Turkish (93 and 96), respectively. The C allele occurred more frequently in UK and Spanish patients (OR 1.76, 95% CI 1.03-3.0, p = 0.037; and OR 1.84, 95% CI 1.1-3.09, p = 0.019), but not in Turkish patients (OR 1.03, 95% CI 0.55-1.97, p = 0.91). Conclusion. In 2 of 3 populations studied, the E-selectin C allele was significantly more common in SLE than in controls, E-selectin may be a susceptibility gene to SLE in these populations. Its role in disease expression and longterm outcomes such as accelerated atherosclerosis requires further study.

AB - Objective. E-selectin is expressed on cytokine stimulated endothelial cells and plays an important role in leukocyte-endothelium interactions and inflammatory cell recruitment. The gene for E-selectin is located at chromosome 1q 23-25 within the linkage area for systemic lupus erythematosus (SLE). The best characterized polymorphism in E-selectin molecule is A561C, which codes for Ser128Arg. We studied the prevalence of the A561C E-selectin gene polymorphism in patients with SLE and controls from 3 different ethnic populations. Methods. Three cohorts of patients with SLE (1987 American College of Rheumatology criteria) and matching population controls were studied. These consisted of Caucasians of British Isles descent, Caucasians of Spanish origin, and Caucasians of Turkish origin. We used polymerase chain reaction and restriction fragment length polymorphism to genotype patients and controls. Results. The numbers of patients and controls in each group were: UK (113 and 148), Spanish (145 and 179), and Turkish (93 and 96), respectively. The C allele occurred more frequently in UK and Spanish patients (OR 1.76, 95% CI 1.03-3.0, p = 0.037; and OR 1.84, 95% CI 1.1-3.09, p = 0.019), but not in Turkish patients (OR 1.03, 95% CI 0.55-1.97, p = 0.91). Conclusion. In 2 of 3 populations studied, the E-selectin C allele was significantly more common in SLE than in controls, E-selectin may be a susceptibility gene to SLE in these populations. Its role in disease expression and longterm outcomes such as accelerated atherosclerosis requires further study.

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