Association of adiponectin promoter variants with traits and clusters of metabolic syndrome in Arabs: Family-based study

F. Zadjali, S. AL-Yahyaee, M. O. Hassan, S. Albarwani, R. A. Bayoumi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Plasma levels of adiponectin are decreased in type 2 diabetes, obesity and hypertension. Our aim was to use a family-based analysis to identify the genetic variants of the adiponectin (ADIPOQ) gene that are associated with obesity, insulin resistance, dyslipidemia and hypertension, among Arabs. We screened 328 Arabs in one large extended family for single nucleotide polymorphisms (SNPs) in the promoter region of the ADIPOQ gene. Two common SNPs were detected: rs17300539 and rs266729. Evidences of association between traits related to the metabolic syndrome and the SNPs were studied by implementing quantitative genetic association analysis. Results showed that SNP rs266729 was significantly associated with body weight (p-value = 0.001), waist circumference (p-value = 0.037), BMI (p-value = 0.015) and percentage of total body fat (p-value = 0.003). Up to 4.1% of heritability of obesity traits was explained by the rs266729 locus. Further cross-sectional analysis showed that carriers of the G allele had significantly higher values of waist circumference, BMI and percentage of total body fat (p-values 0.014, 0.004 and 0.032, respectively). No association was detected between SNP rs266729 and other clusters of metabolic syndrome or their traits except for HOMA-IR and fasting plasma insulin levels, p-values 0.035 and 0.004, respectively. In contrast, both measured genotype and cross-sectional analysis failed to detect an association between the SNP rs17300539 with traits and clusters of metabolic syndrome. In conclusion, we showed family-based evidence of association of SNP rs266729 at ADIPOQ gene with traits defining obesity in Arab population. This is important for future prediction and prevention of obesity in population where obesity is in an increasing trend.

Original languageEnglish
Pages (from-to)663-669
Number of pages7
JournalGene
Volume527
Issue number2
DOIs
Publication statusPublished - Sep 25 2013

Fingerprint

Adiponectin
Single Nucleotide Polymorphism
Obesity
Waist Circumference
Adipose Tissue
Cross-Sectional Studies
Genes
Hypertension
Dyslipidemias
Genetic Promoter Regions
Type 2 Diabetes Mellitus
Population
Insulin Resistance
Fasting
Alleles
Genotype
Body Weight
Insulin

Keywords

  • ADIPOQ
  • Measured genotype analysis
  • Obesity
  • Pedigree

ASJC Scopus subject areas

  • Genetics

Cite this

Association of adiponectin promoter variants with traits and clusters of metabolic syndrome in Arabs : Family-based study. / Zadjali, F.; AL-Yahyaee, S.; Hassan, M. O.; Albarwani, S.; Bayoumi, R. A.

In: Gene, Vol. 527, No. 2, 25.09.2013, p. 663-669.

Research output: Contribution to journalArticle

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abstract = "Plasma levels of adiponectin are decreased in type 2 diabetes, obesity and hypertension. Our aim was to use a family-based analysis to identify the genetic variants of the adiponectin (ADIPOQ) gene that are associated with obesity, insulin resistance, dyslipidemia and hypertension, among Arabs. We screened 328 Arabs in one large extended family for single nucleotide polymorphisms (SNPs) in the promoter region of the ADIPOQ gene. Two common SNPs were detected: rs17300539 and rs266729. Evidences of association between traits related to the metabolic syndrome and the SNPs were studied by implementing quantitative genetic association analysis. Results showed that SNP rs266729 was significantly associated with body weight (p-value = 0.001), waist circumference (p-value = 0.037), BMI (p-value = 0.015) and percentage of total body fat (p-value = 0.003). Up to 4.1{\%} of heritability of obesity traits was explained by the rs266729 locus. Further cross-sectional analysis showed that carriers of the G allele had significantly higher values of waist circumference, BMI and percentage of total body fat (p-values 0.014, 0.004 and 0.032, respectively). No association was detected between SNP rs266729 and other clusters of metabolic syndrome or their traits except for HOMA-IR and fasting plasma insulin levels, p-values 0.035 and 0.004, respectively. In contrast, both measured genotype and cross-sectional analysis failed to detect an association between the SNP rs17300539 with traits and clusters of metabolic syndrome. In conclusion, we showed family-based evidence of association of SNP rs266729 at ADIPOQ gene with traits defining obesity in Arab population. This is important for future prediction and prevention of obesity in population where obesity is in an increasing trend.",
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