Asiatic Acid Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress and Apoptosis Via AKT/GSK-3β Signaling Pathway in Wistar Rats

Mashoque Ahmad Rather, Arokiasamy Justin-Thenmozhi, Thamilarasan Manivasagam, Chidambaram Saravanababu, Gilles J. Guillemin, Mohamed Musthafa Essa

Research output: Contribution to journalArticle

Abstract

Asiatic acid (AA), a triterpenoid present in Centella asiatica, possesses the ability to cross blood brain barrier and received considerable attention for its neuroprotective role. We have reported the benefit of AA against aluminum chloride (AlCl3)-induced amyloid pathology, enhanced acetylcholine esterase (AChE) activity, and inflammation in Alzheimer’s disease (AD) like model rats. Based on that, to find the exact mechanism of action of AA, the present study was designed to evaluate the oxidative stress, tau pathology, apoptosis, and Akt/GSK3β signaling pathway on AlCl3-induced neurotoxicity in Wistar rats. AD-like pathology was induced by oral administration of AlCl3 (100 mg/kg b.w.) for 6 weeks, which demonstrated a significant reduction in spatial memory performance, anxiety, and motor dysfunction and diminished the expression of cyclin-dependent kinase 5 (CDK 5-enzyme implicated in the phosphorylation of tau proteins), pTau, oxidative stress, and apoptosis, whereas oral ingestion of AA (75 mg/kg b.w.) for 7 weeks attenuated the above-said indices, which could be by activating Akt/GSK3β pathway. Current results suggested that AA could be able to modulate various pathological features of AD and could hold promise in AD treatment.

Original languageEnglish
JournalNeurotoxicity Research
DOIs
Publication statusAccepted/In press - Jan 1 2019

Fingerprint

Glycogen Synthase Kinase 3
Oxidative stress
Pathology
Wistar Rats
Rats
Oxidative Stress
Apoptosis
Alzheimer Disease
Performance Anxiety
Centella
Cyclin-Dependent Kinase 5
tau Proteins
Phosphorylation
Aptitude
Esterases
Blood-Brain Barrier
Amyloid
Acetylcholine
Oral Administration
Eating

Keywords

  • Aluminum chloride
  • Apoptosis
  • Asiatic acid
  • Oxidative stress
  • Tau pathology

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

Cite this

Asiatic Acid Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress and Apoptosis Via AKT/GSK-3β Signaling Pathway in Wistar Rats. / Ahmad Rather, Mashoque; Justin-Thenmozhi, Arokiasamy; Manivasagam, Thamilarasan; Saravanababu, Chidambaram; Guillemin, Gilles J.; Essa, Mohamed Musthafa.

In: Neurotoxicity Research, 01.01.2019.

Research output: Contribution to journalArticle

Ahmad Rather, Mashoque ; Justin-Thenmozhi, Arokiasamy ; Manivasagam, Thamilarasan ; Saravanababu, Chidambaram ; Guillemin, Gilles J. ; Essa, Mohamed Musthafa. / Asiatic Acid Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress and Apoptosis Via AKT/GSK-3β Signaling Pathway in Wistar Rats. In: Neurotoxicity Research. 2019.
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