Are scintigraphy and ultrasonography necessary before fine-needle aspiration cytology for thyroid nodules?

Dilip K. Sankhla, Samir S. Hussein, Haddia Bererhi, Omeima El Shafie, Nicholas J. Woodhouse, V. Nirmala

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To evaluate the efficacy of scintigraphy, ultrasound and fine-needle aspiration in thyroid nodules and to establish the best diagnostic pathway in detecting thyroid cancer. Method: Two hundred and sixteen patients with thyroid nodules were examined using high-resolution ultrasonography, 99mTc thyroid scintigraphy and ultrasound-guided fine-needle aspiration. Of these, 113 patients subsequently underwent thyroidectomy. The remaining 103 were followed up for two years without any evidence of malignancy. Results: Cytopathology classified 71% of the aspirate as benign, 3% as positive for malignancy, 21% as suspected neoplasia and 5% as unsatisfactory. Fine- needle aspiration cytology had a sensitivity of 87.5% and specificity of 80%. On ultrasound 33% of malignant nodules were hypo-echoic and on scintigraphy 16% of solitary cold nodules were malignant. Neither test could reliably diagnose thyroid cancer. Conclusion: Ultrasound-guided fine-needle aspiration cytology should be the first test performed in euthyroid patients with a thyroid nodule. Scintigraphy and ultrasound imaging should be reserved for follow-up studies and patients who have suppressed levels of thyroid stimulating hormone.

Original languageEnglish
Pages (from-to)29-33
Number of pages5
JournalSultan Qaboos University Medical Journal
Volume3
Issue number1
Publication statusPublished - Apr 1 2000

Fingerprint

Thyroid Nodule
Fine Needle Biopsy
Radionuclide Imaging
Cell Biology
Ultrasonography
Thyroid Neoplasms
Neoplasms
Thyroidectomy
Thyrotropin
Thyroid Gland
Sensitivity and Specificity

Keywords

  • Fi ne-needle aspiration cytology
  • Thyroid nodule
  • Thyroid scintigraphy
  • Ultrasonography

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Are scintigraphy and ultrasonography necessary before fine-needle aspiration cytology for thyroid nodules? / Sankhla, Dilip K.; Hussein, Samir S.; Bererhi, Haddia; El Shafie, Omeima; Woodhouse, Nicholas J.; Nirmala, V.

In: Sultan Qaboos University Medical Journal, Vol. 3, No. 1, 01.04.2000, p. 29-33.

Research output: Contribution to journalArticle

@article{37ab33729c804a8db905721e0ba296b1,
title = "Are scintigraphy and ultrasonography necessary before fine-needle aspiration cytology for thyroid nodules?",
abstract = "Objective: To evaluate the efficacy of scintigraphy, ultrasound and fine-needle aspiration in thyroid nodules and to establish the best diagnostic pathway in detecting thyroid cancer. Method: Two hundred and sixteen patients with thyroid nodules were examined using high-resolution ultrasonography, 99mTc thyroid scintigraphy and ultrasound-guided fine-needle aspiration. Of these, 113 patients subsequently underwent thyroidectomy. The remaining 103 were followed up for two years without any evidence of malignancy. Results: Cytopathology classified 71{\%} of the aspirate as benign, 3{\%} as positive for malignancy, 21{\%} as suspected neoplasia and 5{\%} as unsatisfactory. Fine- needle aspiration cytology had a sensitivity of 87.5{\%} and specificity of 80{\%}. On ultrasound 33{\%} of malignant nodules were hypo-echoic and on scintigraphy 16{\%} of solitary cold nodules were malignant. Neither test could reliably diagnose thyroid cancer. Conclusion: Ultrasound-guided fine-needle aspiration cytology should be the first test performed in euthyroid patients with a thyroid nodule. Scintigraphy and ultrasound imaging should be reserved for follow-up studies and patients who have suppressed levels of thyroid stimulating hormone.",
keywords = "Fi ne-needle aspiration cytology, Thyroid nodule, Thyroid scintigraphy, Ultrasonography",
author = "Sankhla, {Dilip K.} and Hussein, {Samir S.} and Haddia Bererhi and {El Shafie}, Omeima and Woodhouse, {Nicholas J.} and V. Nirmala",
year = "2000",
month = "4",
day = "1",
language = "English",
volume = "3",
pages = "29--33",
journal = "Sultan Qaboos University Medical Journal",
issn = "2075-051X",
publisher = "Sultan Qaboos University",
number = "1",

}

TY - JOUR

T1 - Are scintigraphy and ultrasonography necessary before fine-needle aspiration cytology for thyroid nodules?

AU - Sankhla, Dilip K.

AU - Hussein, Samir S.

AU - Bererhi, Haddia

AU - El Shafie, Omeima

AU - Woodhouse, Nicholas J.

AU - Nirmala, V.

PY - 2000/4/1

Y1 - 2000/4/1

N2 - Objective: To evaluate the efficacy of scintigraphy, ultrasound and fine-needle aspiration in thyroid nodules and to establish the best diagnostic pathway in detecting thyroid cancer. Method: Two hundred and sixteen patients with thyroid nodules were examined using high-resolution ultrasonography, 99mTc thyroid scintigraphy and ultrasound-guided fine-needle aspiration. Of these, 113 patients subsequently underwent thyroidectomy. The remaining 103 were followed up for two years without any evidence of malignancy. Results: Cytopathology classified 71% of the aspirate as benign, 3% as positive for malignancy, 21% as suspected neoplasia and 5% as unsatisfactory. Fine- needle aspiration cytology had a sensitivity of 87.5% and specificity of 80%. On ultrasound 33% of malignant nodules were hypo-echoic and on scintigraphy 16% of solitary cold nodules were malignant. Neither test could reliably diagnose thyroid cancer. Conclusion: Ultrasound-guided fine-needle aspiration cytology should be the first test performed in euthyroid patients with a thyroid nodule. Scintigraphy and ultrasound imaging should be reserved for follow-up studies and patients who have suppressed levels of thyroid stimulating hormone.

AB - Objective: To evaluate the efficacy of scintigraphy, ultrasound and fine-needle aspiration in thyroid nodules and to establish the best diagnostic pathway in detecting thyroid cancer. Method: Two hundred and sixteen patients with thyroid nodules were examined using high-resolution ultrasonography, 99mTc thyroid scintigraphy and ultrasound-guided fine-needle aspiration. Of these, 113 patients subsequently underwent thyroidectomy. The remaining 103 were followed up for two years without any evidence of malignancy. Results: Cytopathology classified 71% of the aspirate as benign, 3% as positive for malignancy, 21% as suspected neoplasia and 5% as unsatisfactory. Fine- needle aspiration cytology had a sensitivity of 87.5% and specificity of 80%. On ultrasound 33% of malignant nodules were hypo-echoic and on scintigraphy 16% of solitary cold nodules were malignant. Neither test could reliably diagnose thyroid cancer. Conclusion: Ultrasound-guided fine-needle aspiration cytology should be the first test performed in euthyroid patients with a thyroid nodule. Scintigraphy and ultrasound imaging should be reserved for follow-up studies and patients who have suppressed levels of thyroid stimulating hormone.

KW - Fi ne-needle aspiration cytology

KW - Thyroid nodule

KW - Thyroid scintigraphy

KW - Ultrasonography

UR - http://www.scopus.com/inward/record.url?scp=84892484460&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892484460&partnerID=8YFLogxK

M3 - Article

VL - 3

SP - 29

EP - 33

JO - Sultan Qaboos University Medical Journal

JF - Sultan Qaboos University Medical Journal

SN - 2075-051X

IS - 1

ER -