Aqua mediated synthesis of substituted 2-amino-4H-chromenes and in vitro study as antibacterial agents

Mazaahir Kidwai, Shilpi Saxena, M. Khalilur Rahman Khan, Sharanjit S. Thukral

Research output: Contribution to journalArticle

364 Citations (Scopus)

Abstract

A simple, clean, environmentally benign route to the synthesis of 2-amino-chromenes is described using K 2CO 3 as a green catalyst in water under microwave irradiation. This implies a convenient route avoiding the usage of hazardous organic solvents and organic bases. This technique requires only water in both the reaction step and workup, thus rendering the whole procedure into a truly ecofriendly green protocol. All the synthesized compounds were shown to possess antibacterial activity as tested in vitro against standard strains of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus.

Original languageEnglish
Pages (from-to)4295-4298
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number19
DOIs
Publication statusPublished - Oct 1 2005

Keywords

  • 4H-chromenes
  • Antibacterial agents
  • Microwave irradiation
  • Solvent-free

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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