Aqua mediated synthesis of substituted 2-amino-4H-chromenes and in vitro study as antibacterial agents

Mazaahir Kidwai; Shilpi Saxena; M. Khalilur Rahman Khan; Sharanjit S. Thukral

doi:10.1016/j.bmcl.2005.06.041

Aqua mediated synthesis of substituted 2-amino-4H-chromenes and in vitro study as antibacterial agents

Mazaahir Kidwai^*, Shilpi Saxena, M. Khalilur Rahman Khan, Sharanjit S. Thukral

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

451 Citations (Scopus)

Abstract

A simple, clean, environmentally benign route to the synthesis of 2-amino-chromenes is described using K₂CO₃ as a green catalyst in water under microwave irradiation. This implies a convenient route avoiding the usage of hazardous organic solvents and organic bases. This technique requires only water in both the reaction step and workup, thus rendering the whole procedure into a truly ecofriendly green protocol. All the synthesized compounds were shown to possess antibacterial activity as tested in vitro against standard strains of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus.

Original language	English
Pages (from-to)	4295-4298
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	15
Issue number	19
DOIs	https://doi.org/10.1016/j.bmcl.2005.06.041
Publication status	Published - Oct 1 2005
Externally published	Yes

Keywords

4H-chromenes
Antibacterial agents
Microwave irradiation
Solvent-free

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2005.06.041

Cite this

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title = "Aqua mediated synthesis of substituted 2-amino-4H-chromenes and in vitro study as antibacterial agents",

abstract = "A simple, clean, environmentally benign route to the synthesis of 2-amino-chromenes is described using K2CO3 as a green catalyst in water under microwave irradiation. This implies a convenient route avoiding the usage of hazardous organic solvents and organic bases. This technique requires only water in both the reaction step and workup, thus rendering the whole procedure into a truly ecofriendly green protocol. All the synthesized compounds were shown to possess antibacterial activity as tested in vitro against standard strains of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus.",

keywords = "4H-chromenes, Antibacterial agents, Microwave irradiation, Solvent-free",

author = "Mazaahir Kidwai and Shilpi Saxena and Khan, {M. Khalilur Rahman} and Thukral, {Sharanjit S.}",

note = "Funding Information: The authors M. Kidwai and S. Saxena are thankful to University Grants Commission, New Delhi, for financial assistance. ",

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doi = "10.1016/j.bmcl.2005.06.041",

language = "English",

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T1 - Aqua mediated synthesis of substituted 2-amino-4H-chromenes and in vitro study as antibacterial agents

AU - Kidwai, Mazaahir

AU - Saxena, Shilpi

AU - Khan, M. Khalilur Rahman

AU - Thukral, Sharanjit S.

N1 - Funding Information: The authors M. Kidwai and S. Saxena are thankful to University Grants Commission, New Delhi, for financial assistance.

PY - 2005/10/1

Y1 - 2005/10/1

N2 - A simple, clean, environmentally benign route to the synthesis of 2-amino-chromenes is described using K2CO3 as a green catalyst in water under microwave irradiation. This implies a convenient route avoiding the usage of hazardous organic solvents and organic bases. This technique requires only water in both the reaction step and workup, thus rendering the whole procedure into a truly ecofriendly green protocol. All the synthesized compounds were shown to possess antibacterial activity as tested in vitro against standard strains of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus.

AB - A simple, clean, environmentally benign route to the synthesis of 2-amino-chromenes is described using K2CO3 as a green catalyst in water under microwave irradiation. This implies a convenient route avoiding the usage of hazardous organic solvents and organic bases. This technique requires only water in both the reaction step and workup, thus rendering the whole procedure into a truly ecofriendly green protocol. All the synthesized compounds were shown to possess antibacterial activity as tested in vitro against standard strains of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus.

KW - 4H-chromenes

KW - Antibacterial agents

KW - Microwave irradiation

KW - Solvent-free

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

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ER -

Aqua mediated synthesis of substituted 2-amino-4H-chromenes and in vitro study as antibacterial agents

Abstract

Keywords

ASJC Scopus subject areas

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