Antifungal properties of nanosized ZnS particles synthesised by sonochemical precipitation

P. Suyana, S. Nishanth Kumar, B. S.Dileep Kumar, Balagopal N. Nair, Suresh C. Pillai, A. Peer Mohamed, K. G.K. Warrier, U. S. Hareesh*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Zinc sulphide (ZnS) nanoparticles, synthesised by a sonochemical route employing zinc chloride and sodium sulphide, displayed significant antifungal properties against the pathogenic yeast Candida albicans (MTCC 227) at a minimum fungicidal concentration of 300 μg ml-1. The antifungal properties of zinc sulphide particles is attributed to the generation of reactive oxygen species due to the interaction of the nanoparticles with water. Additionally, the presence of Zn in the zone of inhibition and the absence of antifungal effects for large micron sized particles of ZnS suggest a size induced effect leading to perturbation of fungal cell membranes, resulting in growth inhibition.

Original languageEnglish
Pages (from-to)8439-8445
Number of pages7
JournalRSC Advances
Volume4
Issue number17
DOIs
Publication statusPublished - 2014
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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