Anti-inflammatory, antipyretic, and analgesic effects of Lawsonia inermis L. (henna) in rats

B. H. Ali, A. K. Bashir, M. O M Tanira

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Crude ethanolic extract of Lawsonia inermis L. (0.25-2.0 g/kg) produced significant and dose-dependent anti-inflammatory, analgesic, and antipyretic effects in rats. The extract also produced significant increases in pentobarbitone-induced sleeping time. Using a liquid-liquid extraction procedure, the extract was fractionated into chloroform, butanol, and water fractions, and these were tested for the above activities. The butanol and chloroform fractions showed more potent antiinflammatory, analgesic, and antipyretic effects than the crude extracts, while the aqueous extract showed significantly less effect. As compared with the other extracts, the butanolic extract (500 mg/kg) was the most effective in the analgesic test. From the chloroform extract, a pure compound was isolated and identified, using chromatographic and spectroscopic techniques, as 2-hydroxy-1,4-naphthaquinone (lawsone). The isolated compound was found to possess significant antiinflammatory, analgesic, and antipyretic activity. It potentiated significantly the pentobarbitone-induced sleeping time. The anti-inflammatory effect of lawsone (500 mg/kg) was not significantly different from that of the reference drug phenylbutazone (100 mg/kg).

Original languageEnglish
Pages (from-to)356-363
Number of pages8
JournalPharmacology
Volume51
Issue number6
Publication statusPublished - 1995

Fingerprint

Lawsonia Plant
Antipyretics
Non-Steroidal Anti-Inflammatory Agents
Chloroform
Analgesics
Butanols
Anti-Inflammatory Agents
Pentobarbital
Complex Mixtures
Phenylbutazone
Liquid-Liquid Extraction
Water
Pharmaceutical Preparations
lawsone

Keywords

  • Analgesic, anti-inflammatory, antipyretic effects
  • Lawsone
  • Lawsonia inermis L.

ASJC Scopus subject areas

  • Pharmacology

Cite this

Anti-inflammatory, antipyretic, and analgesic effects of Lawsonia inermis L. (henna) in rats. / Ali, B. H.; Bashir, A. K.; Tanira, M. O M.

In: Pharmacology, Vol. 51, No. 6, 1995, p. 356-363.

Research output: Contribution to journalArticle

@article{bcd44edd8b7e41518c7bb4a2e045923b,
title = "Anti-inflammatory, antipyretic, and analgesic effects of Lawsonia inermis L. (henna) in rats",
abstract = "Crude ethanolic extract of Lawsonia inermis L. (0.25-2.0 g/kg) produced significant and dose-dependent anti-inflammatory, analgesic, and antipyretic effects in rats. The extract also produced significant increases in pentobarbitone-induced sleeping time. Using a liquid-liquid extraction procedure, the extract was fractionated into chloroform, butanol, and water fractions, and these were tested for the above activities. The butanol and chloroform fractions showed more potent antiinflammatory, analgesic, and antipyretic effects than the crude extracts, while the aqueous extract showed significantly less effect. As compared with the other extracts, the butanolic extract (500 mg/kg) was the most effective in the analgesic test. From the chloroform extract, a pure compound was isolated and identified, using chromatographic and spectroscopic techniques, as 2-hydroxy-1,4-naphthaquinone (lawsone). The isolated compound was found to possess significant antiinflammatory, analgesic, and antipyretic activity. It potentiated significantly the pentobarbitone-induced sleeping time. The anti-inflammatory effect of lawsone (500 mg/kg) was not significantly different from that of the reference drug phenylbutazone (100 mg/kg).",
keywords = "Analgesic, anti-inflammatory, antipyretic effects, Lawsone, Lawsonia inermis L.",
author = "Ali, {B. H.} and Bashir, {A. K.} and Tanira, {M. O M}",
year = "1995",
language = "English",
volume = "51",
pages = "356--363",
journal = "Pharmacology",
issn = "0031-7012",
publisher = "S. Karger AG",
number = "6",

}

TY - JOUR

T1 - Anti-inflammatory, antipyretic, and analgesic effects of Lawsonia inermis L. (henna) in rats

AU - Ali, B. H.

AU - Bashir, A. K.

AU - Tanira, M. O M

PY - 1995

Y1 - 1995

N2 - Crude ethanolic extract of Lawsonia inermis L. (0.25-2.0 g/kg) produced significant and dose-dependent anti-inflammatory, analgesic, and antipyretic effects in rats. The extract also produced significant increases in pentobarbitone-induced sleeping time. Using a liquid-liquid extraction procedure, the extract was fractionated into chloroform, butanol, and water fractions, and these were tested for the above activities. The butanol and chloroform fractions showed more potent antiinflammatory, analgesic, and antipyretic effects than the crude extracts, while the aqueous extract showed significantly less effect. As compared with the other extracts, the butanolic extract (500 mg/kg) was the most effective in the analgesic test. From the chloroform extract, a pure compound was isolated and identified, using chromatographic and spectroscopic techniques, as 2-hydroxy-1,4-naphthaquinone (lawsone). The isolated compound was found to possess significant antiinflammatory, analgesic, and antipyretic activity. It potentiated significantly the pentobarbitone-induced sleeping time. The anti-inflammatory effect of lawsone (500 mg/kg) was not significantly different from that of the reference drug phenylbutazone (100 mg/kg).

AB - Crude ethanolic extract of Lawsonia inermis L. (0.25-2.0 g/kg) produced significant and dose-dependent anti-inflammatory, analgesic, and antipyretic effects in rats. The extract also produced significant increases in pentobarbitone-induced sleeping time. Using a liquid-liquid extraction procedure, the extract was fractionated into chloroform, butanol, and water fractions, and these were tested for the above activities. The butanol and chloroform fractions showed more potent antiinflammatory, analgesic, and antipyretic effects than the crude extracts, while the aqueous extract showed significantly less effect. As compared with the other extracts, the butanolic extract (500 mg/kg) was the most effective in the analgesic test. From the chloroform extract, a pure compound was isolated and identified, using chromatographic and spectroscopic techniques, as 2-hydroxy-1,4-naphthaquinone (lawsone). The isolated compound was found to possess significant antiinflammatory, analgesic, and antipyretic activity. It potentiated significantly the pentobarbitone-induced sleeping time. The anti-inflammatory effect of lawsone (500 mg/kg) was not significantly different from that of the reference drug phenylbutazone (100 mg/kg).

KW - Analgesic, anti-inflammatory, antipyretic effects

KW - Lawsone

KW - Lawsonia inermis L.

UR - http://www.scopus.com/inward/record.url?scp=0028853673&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028853673&partnerID=8YFLogxK

M3 - Article

C2 - 8966192

AN - SCOPUS:0028853673

VL - 51

SP - 356

EP - 363

JO - Pharmacology

JF - Pharmacology

SN - 0031-7012

IS - 6

ER -