Anemia in adenine-induced chronic renal failure and the influence of treatment with gum acacia thereon

B. H. Ali, M. Al Za'Abi, A. Ramkumar, J. Yasin, A. Nemmar

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Anemia frequently complicates chronic kidney disease (CKD). We investigated here the effect of adenine-induced CKD in rats on erythrocyte count (EC), hematocrit (PCV) and hemoglobin (Hb) concentration, as well as on the activity of L-γ-glutamyl transferase (GGT) and the concentrations of iron (Fe), transferrin (Tf), ferritin (F), total iron binding capacity (TIBC) / unsaturated iron binding capacity (UIBC) and hepcidin (Hp) in serum and erythropoietin (Epo) in renal tissue. Renal damage was assessed histopathologically, and also by measuring the serum concentrations of the uremic toxin indoxyl sulfate (IS), creatinine, and urea, and by creatinine clearance. We also assessed the influence of concomitant treatment with gum acacia (GA) on the above analytes. Adenine feeding induced CKD, accompanied by significant decreases (P

Original languageEnglish
Pages (from-to)351-358
Number of pages8
JournalPhysiological Research
Issue number3
Publication statusPublished - 2014



  • Adenine
  • Anemia
  • Chronic renal failure
  • Gum acacia
  • Iron
  • Rats

ASJC Scopus subject areas

  • Physiology
  • Medicine(all)

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