Analysis of fexofenadine in pharmaceutical formulations using tris(1,10-phenanthroline)-ruthenium(II) peroxydisulphate chemiluminescence system in a multichip device

Haider A.J. Al Lawati; Zeiyana M. Al Dahmani; Fakhr Eldin O. Suliman; Salma M.Z. Al Kindy; Ali M. Al-Lawati

doi:10.1002/bio.1310

Analysis of fexofenadine in pharmaceutical formulations using tris(1,10-phenanthroline)-ruthenium(II) peroxydisulphate chemiluminescence system in a multichip device

Haider A.J. Al Lawati^*, Zeiyana M. Al Dahmani, Fakhr Eldin O. Suliman, Salma M.Z. Al Kindy, Ali M. Al-Lawati

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

A simple, rapid and sensitive method has been developed for the analysis of fexofenadine (FEX) in pharmaceutical formulations, using a tris(1,10- phenanthroline)-ruthenium(II) [Ru(phen)₃ ²⁺] peroxydisulphate chemiluminescence (CL) system in a multichip device. Various parameters that influence the CL signal intensity were optimized. These included pH, flow rates and concentration of reagents used. Under optimum conditions, a linear calibration curve in the range 0.05-5.0 μg/mL was obtained. The detection limit was found to be 0.001 μg/mL. The procedure was applied to the analysis of FEX in pharmaceutical products and was found to be free from interference from concomitants usually present in these preparations.

Original language	English
Pages (from-to)	762-767
Number of pages	6
Journal	Luminescence
Volume	26
Issue number	6
DOIs	https://doi.org/10.1002/bio.1310
Publication status	Published - 2011

Keywords

ammonium peroxodisulphate
chemiluminescence
fexofenadine
microfluidics
multichip
tris(1,10- phenanthroline)-ruthenium(II)

ASJC Scopus subject areas

Biophysics
Chemistry (miscellaneous)

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title = "Analysis of fexofenadine in pharmaceutical formulations using tris(1,10-phenanthroline)-ruthenium(II) peroxydisulphate chemiluminescence system in a multichip device",

abstract = "A simple, rapid and sensitive method has been developed for the analysis of fexofenadine (FEX) in pharmaceutical formulations, using a tris(1,10- phenanthroline)-ruthenium(II) [Ru(phen)3 2+] peroxydisulphate chemiluminescence (CL) system in a multichip device. Various parameters that influence the CL signal intensity were optimized. These included pH, flow rates and concentration of reagents used. Under optimum conditions, a linear calibration curve in the range 0.05-5.0 μg/mL was obtained. The detection limit was found to be 0.001 μg/mL. The procedure was applied to the analysis of FEX in pharmaceutical products and was found to be free from interference from concomitants usually present in these preparations.",

keywords = "ammonium peroxodisulphate, chemiluminescence, fexofenadine, microfluidics, multichip, tris(1,10- phenanthroline)-ruthenium(II)",

author = "{Al Lawati}, {Haider A.J.} and {Al Dahmani}, {Zeiyana M.} and Suliman, {Fakhr Eldin O.} and {Al Kindy}, {Salma M.Z.} and Al-Lawati, {Ali M.}",

year = "2011",

doi = "10.1002/bio.1310",

language = "English",

volume = "26",

pages = "762--767",

journal = "Luminescence",

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AU - Al Lawati, Haider A.J.

AU - Al Dahmani, Zeiyana M.

AU - Suliman, Fakhr Eldin O.

AU - Al Kindy, Salma M.Z.

AU - Al-Lawati, Ali M.

PY - 2011

Y1 - 2011

N2 - A simple, rapid and sensitive method has been developed for the analysis of fexofenadine (FEX) in pharmaceutical formulations, using a tris(1,10- phenanthroline)-ruthenium(II) [Ru(phen)3 2+] peroxydisulphate chemiluminescence (CL) system in a multichip device. Various parameters that influence the CL signal intensity were optimized. These included pH, flow rates and concentration of reagents used. Under optimum conditions, a linear calibration curve in the range 0.05-5.0 μg/mL was obtained. The detection limit was found to be 0.001 μg/mL. The procedure was applied to the analysis of FEX in pharmaceutical products and was found to be free from interference from concomitants usually present in these preparations.

AB - A simple, rapid and sensitive method has been developed for the analysis of fexofenadine (FEX) in pharmaceutical formulations, using a tris(1,10- phenanthroline)-ruthenium(II) [Ru(phen)3 2+] peroxydisulphate chemiluminescence (CL) system in a multichip device. Various parameters that influence the CL signal intensity were optimized. These included pH, flow rates and concentration of reagents used. Under optimum conditions, a linear calibration curve in the range 0.05-5.0 μg/mL was obtained. The detection limit was found to be 0.001 μg/mL. The procedure was applied to the analysis of FEX in pharmaceutical products and was found to be free from interference from concomitants usually present in these preparations.

KW - ammonium peroxodisulphate

KW - chemiluminescence

KW - fexofenadine

KW - microfluidics

KW - multichip

KW - tris(1,10- phenanthroline)-ruthenium(II)

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ER -

Analysis of fexofenadine in pharmaceutical formulations using tris(1,10-phenanthroline)-ruthenium(II) peroxydisulphate chemiluminescence system in a multichip device

Abstract

Keywords

ASJC Scopus subject areas

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