Analysis of fexofenadine in pharmaceutical formulations using tris(1,10-phenanthroline)-ruthenium(II) peroxydisulphate chemiluminescence system in a multichip device

Haider A J Al Lawati, Zeiyana M. Al Dahmani, Fakhr Eldin O Suliman, Salma M Z Al Kindy, Ali M. Al-Lawati

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A simple, rapid and sensitive method has been developed for the analysis of fexofenadine (FEX) in pharmaceutical formulations, using a tris(1,10- phenanthroline)-ruthenium(II) [Ru(phen) 3 2+] peroxydisulphate chemiluminescence (CL) system in a multichip device. Various parameters that influence the CL signal intensity were optimized. These included pH, flow rates and concentration of reagents used. Under optimum conditions, a linear calibration curve in the range 0.05-5.0 μg/mL was obtained. The detection limit was found to be 0.001 μg/mL. The procedure was applied to the analysis of FEX in pharmaceutical products and was found to be free from interference from concomitants usually present in these preparations.

Original languageEnglish
Pages (from-to)762-767
Number of pages6
JournalLuminescence
Volume26
Issue number6
DOIs
Publication statusPublished - Nov 2011

Fingerprint

fexofenadine
Drug Compounding
Chemiluminescence
Luminescence
Equipment and Supplies
Pharmaceutical Preparations
Calibration
Limit of Detection
Flow rate
tris-(1,10-phenanthroline)ruthenium

Keywords

  • ammonium peroxodisulphate
  • chemiluminescence
  • fexofenadine
  • microfluidics
  • multichip
  • tris(1,10- phenanthroline)-ruthenium(II)

ASJC Scopus subject areas

  • Biophysics
  • Chemistry (miscellaneous)

Cite this

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title = "Analysis of fexofenadine in pharmaceutical formulations using tris(1,10-phenanthroline)-ruthenium(II) peroxydisulphate chemiluminescence system in a multichip device",
abstract = "A simple, rapid and sensitive method has been developed for the analysis of fexofenadine (FEX) in pharmaceutical formulations, using a tris(1,10- phenanthroline)-ruthenium(II) [Ru(phen) 3 2+] peroxydisulphate chemiluminescence (CL) system in a multichip device. Various parameters that influence the CL signal intensity were optimized. These included pH, flow rates and concentration of reagents used. Under optimum conditions, a linear calibration curve in the range 0.05-5.0 μg/mL was obtained. The detection limit was found to be 0.001 μg/mL. The procedure was applied to the analysis of FEX in pharmaceutical products and was found to be free from interference from concomitants usually present in these preparations.",
keywords = "ammonium peroxodisulphate, chemiluminescence, fexofenadine, microfluidics, multichip, tris(1,10- phenanthroline)-ruthenium(II)",
author = "{Al Lawati}, {Haider A J} and {Al Dahmani}, {Zeiyana M.} and Suliman, {Fakhr Eldin O} and {Al Kindy}, {Salma M Z} and Al-Lawati, {Ali M.}",
year = "2011",
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language = "English",
volume = "26",
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T1 - Analysis of fexofenadine in pharmaceutical formulations using tris(1,10-phenanthroline)-ruthenium(II) peroxydisulphate chemiluminescence system in a multichip device

AU - Al Lawati, Haider A J

AU - Al Dahmani, Zeiyana M.

AU - Suliman, Fakhr Eldin O

AU - Al Kindy, Salma M Z

AU - Al-Lawati, Ali M.

PY - 2011/11

Y1 - 2011/11

N2 - A simple, rapid and sensitive method has been developed for the analysis of fexofenadine (FEX) in pharmaceutical formulations, using a tris(1,10- phenanthroline)-ruthenium(II) [Ru(phen) 3 2+] peroxydisulphate chemiluminescence (CL) system in a multichip device. Various parameters that influence the CL signal intensity were optimized. These included pH, flow rates and concentration of reagents used. Under optimum conditions, a linear calibration curve in the range 0.05-5.0 μg/mL was obtained. The detection limit was found to be 0.001 μg/mL. The procedure was applied to the analysis of FEX in pharmaceutical products and was found to be free from interference from concomitants usually present in these preparations.

AB - A simple, rapid and sensitive method has been developed for the analysis of fexofenadine (FEX) in pharmaceutical formulations, using a tris(1,10- phenanthroline)-ruthenium(II) [Ru(phen) 3 2+] peroxydisulphate chemiluminescence (CL) system in a multichip device. Various parameters that influence the CL signal intensity were optimized. These included pH, flow rates and concentration of reagents used. Under optimum conditions, a linear calibration curve in the range 0.05-5.0 μg/mL was obtained. The detection limit was found to be 0.001 μg/mL. The procedure was applied to the analysis of FEX in pharmaceutical products and was found to be free from interference from concomitants usually present in these preparations.

KW - ammonium peroxodisulphate

KW - chemiluminescence

KW - fexofenadine

KW - microfluidics

KW - multichip

KW - tris(1,10- phenanthroline)-ruthenium(II)

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DO - 10.1002/bio.1310

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