Analyses of anticancer drugs by capillary electrophoresis: A review

Imran Ali, Ashanul Haque, Waseem A. Wani, Kishwar Saleem, Mohammed Al Za'abi

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Capillary electrophoresis is a fast, inexpensive and low detection limit technique for the analysis of anticancer drugs. It has been used to analyze various anticancer drugs in biological samples, pharmaceutical preparations and environmental matrices. It has also been used to detect various cancer biomarkers in cancer patients. The present article describes the state-of-the art of capillary electrophoresis for the analyses of anticancer drugs. Various drugs discussed belong to several groups such as antimitotic agents, nucleoside analogs, antibiotics, topoisomerase inhibitors and DNA intercalating agents. In addition, efforts have also been made to discuss sample preparation, applications of capillary electrophoresis in genomic research, optimization and future perspectives.

Original languageEnglish
Pages (from-to)1296-1311
Number of pages16
JournalBiomedical Chromatography
Volume27
Issue number10
DOIs
Publication statusPublished - Oct 2013

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Keywords

  • Anticancer drugs
  • Biological samples
  • Capillary electrophoresis
  • Future perspectives

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Drug Discovery
  • Pharmacology

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