Anaesthesia management of a patient with hereditary angioedema with prophylactic administration of C1 esterase inhibitor: Case report and literature review

Aravind Narayanan, Rohit R. Date, Sanathkumar Birur, Pradipta Bhakta, Sinnakirouchenane Srinivasan

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Hereditary angioedema (HAE) is a rare disorder caused by a deficiency of C1 esterase inhibitor. Minor trauma and emotional stress are the most common initiating events leading to contact system activation and excessive uncontrolled bradykinin release. This manifests as angioedema, a vascular reaction of the deeper layers of the skin and mucous membranes, with vasodilatation and increased permeability resulting in tissue swelling. Severe angioedema can occur in the perioperative period, leading to fatal airway obstruction. We describe the anaesthetic management of a child with HAE for dental rehabilitation and provide an review of the relevant literature.

Original languageEnglish
Pages (from-to)467-471
Number of pages5
JournalSultan Qaboos University Medical Journal
Volume13
Issue number3
Publication statusPublished - Aug 2013

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Keywords

  • Anesthesia
  • C1 esterase inhibitor deficiency
  • Case report
  • Hereditary angioedema
  • Oman

ASJC Scopus subject areas

  • Medicine(all)

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