Anaesthesia management of a patient with hereditary angioedema with prophylactic administration of C1 esterase inhibitor

Case report and literature review

Aravind Narayanan, Rohit R. Date, Sanathkumar Birur, Pradipta Bhakta, Sinnakirouchenane Srinivasan

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Hereditary angioedema (HAE) is a rare disorder caused by a deficiency of C1 esterase inhibitor. Minor trauma and emotional stress are the most common initiating events leading to contact system activation and excessive uncontrolled bradykinin release. This manifests as angioedema, a vascular reaction of the deeper layers of the skin and mucous membranes, with vasodilatation and increased permeability resulting in tissue swelling. Severe angioedema can occur in the perioperative period, leading to fatal airway obstruction. We describe the anaesthetic management of a child with HAE for dental rehabilitation and provide an review of the relevant literature.

Original languageEnglish
Pages (from-to)467-471
Number of pages5
JournalSultan Qaboos University Medical Journal
Volume13
Issue number3
Publication statusPublished - Aug 2013

Fingerprint

Complement C1 Inhibitor Protein
Hereditary Angioedemas
Angioedema
Hereditary Angioedema Types I and II
Anesthesia
Perioperative Period
Bradykinin
Airway Obstruction
Psychological Stress
Vasodilation
Blood Vessels
Anesthetics
Permeability
Tooth
Mucous Membrane
Rehabilitation
Skin
Wounds and Injuries

Keywords

  • Anesthesia
  • C1 esterase inhibitor deficiency
  • Case report
  • Hereditary angioedema
  • Oman

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Anaesthesia management of a patient with hereditary angioedema with prophylactic administration of C1 esterase inhibitor : Case report and literature review. / Narayanan, Aravind; Date, Rohit R.; Birur, Sanathkumar; Bhakta, Pradipta; Srinivasan, Sinnakirouchenane.

In: Sultan Qaboos University Medical Journal, Vol. 13, No. 3, 08.2013, p. 467-471.

Research output: Contribution to journalArticle

@article{b25b462f984f4fbe967a91836aac452d,
title = "Anaesthesia management of a patient with hereditary angioedema with prophylactic administration of C1 esterase inhibitor: Case report and literature review",
abstract = "Hereditary angioedema (HAE) is a rare disorder caused by a deficiency of C1 esterase inhibitor. Minor trauma and emotional stress are the most common initiating events leading to contact system activation and excessive uncontrolled bradykinin release. This manifests as angioedema, a vascular reaction of the deeper layers of the skin and mucous membranes, with vasodilatation and increased permeability resulting in tissue swelling. Severe angioedema can occur in the perioperative period, leading to fatal airway obstruction. We describe the anaesthetic management of a child with HAE for dental rehabilitation and provide an review of the relevant literature.",
keywords = "Anesthesia, C1 esterase inhibitor deficiency, Case report, Hereditary angioedema, Oman",
author = "Aravind Narayanan and Date, {Rohit R.} and Sanathkumar Birur and Pradipta Bhakta and Sinnakirouchenane Srinivasan",
year = "2013",
month = "8",
language = "English",
volume = "13",
pages = "467--471",
journal = "Sultan Qaboos University Medical Journal",
issn = "2075-051X",
publisher = "Sultan Qaboos University",
number = "3",

}

TY - JOUR

T1 - Anaesthesia management of a patient with hereditary angioedema with prophylactic administration of C1 esterase inhibitor

T2 - Case report and literature review

AU - Narayanan, Aravind

AU - Date, Rohit R.

AU - Birur, Sanathkumar

AU - Bhakta, Pradipta

AU - Srinivasan, Sinnakirouchenane

PY - 2013/8

Y1 - 2013/8

N2 - Hereditary angioedema (HAE) is a rare disorder caused by a deficiency of C1 esterase inhibitor. Minor trauma and emotional stress are the most common initiating events leading to contact system activation and excessive uncontrolled bradykinin release. This manifests as angioedema, a vascular reaction of the deeper layers of the skin and mucous membranes, with vasodilatation and increased permeability resulting in tissue swelling. Severe angioedema can occur in the perioperative period, leading to fatal airway obstruction. We describe the anaesthetic management of a child with HAE for dental rehabilitation and provide an review of the relevant literature.

AB - Hereditary angioedema (HAE) is a rare disorder caused by a deficiency of C1 esterase inhibitor. Minor trauma and emotional stress are the most common initiating events leading to contact system activation and excessive uncontrolled bradykinin release. This manifests as angioedema, a vascular reaction of the deeper layers of the skin and mucous membranes, with vasodilatation and increased permeability resulting in tissue swelling. Severe angioedema can occur in the perioperative period, leading to fatal airway obstruction. We describe the anaesthetic management of a child with HAE for dental rehabilitation and provide an review of the relevant literature.

KW - Anesthesia

KW - C1 esterase inhibitor deficiency

KW - Case report

KW - Hereditary angioedema

KW - Oman

UR - http://www.scopus.com/inward/record.url?scp=84880960952&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880960952&partnerID=8YFLogxK

M3 - Article

VL - 13

SP - 467

EP - 471

JO - Sultan Qaboos University Medical Journal

JF - Sultan Qaboos University Medical Journal

SN - 2075-051X

IS - 3

ER -