Altered blood cytokines, CD4 T cells, NK and neutrophils in patients with obstructive sleep apnea

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background There are contradictory reports on the effects of obstructive sleep apnea (OSA) on the immune system. In order to clarify the effect of OSA on the different components of the immune system, we studied the association of OSA with changes in cytokine and chemokine levels, proliferative patterns of CD4 and CD8 T lymphocytes as well as NK cells ex vivo and neutrophil functions. Methods We investigated the association of OSA with potential alterations in 14 Th1/Th2 and inflammatory cytokines and chemokines, CD4 and CD8 T cells, NK cells, and the NADPH oxidase activation and phagocytic functions in neutrophils. Results Our results suggest that the increase in CD4 T cell frequency in OSA is associated with an increased expression of the nuclear protein Ki67 (p < 0.05; power > 0.8), and is correlated with the levels of IL-1β (p < 0.05; power > 0.8). The levels of IL-1β as well as IL-6 showed a potential increase, while the levels of IFN-γ (p < 0.05; power > 0.8) and the ratio IFN-γ/IL-4 in the blood were possibly decreased in OSA. Additionally, we observed a potential increase in the expression of Ki67 in CD8hi and CD8lo NK cells (p < 0.05; power > 0.8). Our results also suggest that neutrophils have a decreased capacity to phagocytose bacteria and activate NADPH oxidase in OSA patients (p < 0.05; power > 0.8). Conclusion OSA may be associated with inflammatory and pro-Th2 immune responses, an increased proliferative potential of NK and CD4 T cells and a decreased capacity of neutrophils to phagocytose bacteria and produce ROS.

Original languageEnglish
Pages (from-to)272-278
Number of pages7
JournalImmunology Letters
Volume190
DOIs
Publication statusPublished - Oct 1 2017

Fingerprint

Obstructive Sleep Apnea
Neutrophils
Cytokines
T-Lymphocytes
Natural Killer Cells
NADPH Oxidase
Interleukin-1
Phagocytosis
Chemokines
Immune System
Bacteria
Nuclear Proteins
Interleukin-4
Interleukin-6

Keywords

  • Cytokines
  • Inflammation
  • Neutrophils
  • NK cells
  • Sleep apnea
  • Th1/Th2

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

@article{484ddda9a34c466c9a7b90cb74df7ffb,
title = "Altered blood cytokines, CD4 T cells, NK and neutrophils in patients with obstructive sleep apnea",
abstract = "Background There are contradictory reports on the effects of obstructive sleep apnea (OSA) on the immune system. In order to clarify the effect of OSA on the different components of the immune system, we studied the association of OSA with changes in cytokine and chemokine levels, proliferative patterns of CD4 and CD8 T lymphocytes as well as NK cells ex vivo and neutrophil functions. Methods We investigated the association of OSA with potential alterations in 14 Th1/Th2 and inflammatory cytokines and chemokines, CD4 and CD8 T cells, NK cells, and the NADPH oxidase activation and phagocytic functions in neutrophils. Results Our results suggest that the increase in CD4 T cell frequency in OSA is associated with an increased expression of the nuclear protein Ki67 (p < 0.05; power > 0.8), and is correlated with the levels of IL-1β (p < 0.05; power > 0.8). The levels of IL-1β as well as IL-6 showed a potential increase, while the levels of IFN-γ (p < 0.05; power > 0.8) and the ratio IFN-γ/IL-4 in the blood were possibly decreased in OSA. Additionally, we observed a potential increase in the expression of Ki67 in CD8hi and CD8lo NK cells (p < 0.05; power > 0.8). Our results also suggest that neutrophils have a decreased capacity to phagocytose bacteria and activate NADPH oxidase in OSA patients (p < 0.05; power > 0.8). Conclusion OSA may be associated with inflammatory and pro-Th2 immune responses, an increased proliferative potential of NK and CD4 T cells and a decreased capacity of neutrophils to phagocytose bacteria and produce ROS.",
keywords = "Cytokines, Inflammation, Neutrophils, NK cells, Sleep apnea, Th1/Th2",
author = "Said, {Elias A.} and Al-Abri, {Mohammed A.} and Iman Al-Saidi and Al-Balushi, {Mohammed S.} and Al-Busaidi, {Jumaa Z.} and Iman Al-Reesi and Koh, {Crystal Y.} and Hasson, {Sidgi S.} and Idris, {Mohamed A.} and Al-Jabri, {Ali A.} and Omar Habbal",
year = "2017",
month = "10",
day = "1",
doi = "10.1016/j.imlet.2017.08.009",
language = "English",
volume = "190",
pages = "272--278",
journal = "Immunology Letters",
issn = "0165-2478",
publisher = "Elsevier",

}

TY - JOUR

T1 - Altered blood cytokines, CD4 T cells, NK and neutrophils in patients with obstructive sleep apnea

AU - Said, Elias A.

AU - Al-Abri, Mohammed A.

AU - Al-Saidi, Iman

AU - Al-Balushi, Mohammed S.

AU - Al-Busaidi, Jumaa Z.

AU - Al-Reesi, Iman

AU - Koh, Crystal Y.

AU - Hasson, Sidgi S.

AU - Idris, Mohamed A.

AU - Al-Jabri, Ali A.

AU - Habbal, Omar

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Background There are contradictory reports on the effects of obstructive sleep apnea (OSA) on the immune system. In order to clarify the effect of OSA on the different components of the immune system, we studied the association of OSA with changes in cytokine and chemokine levels, proliferative patterns of CD4 and CD8 T lymphocytes as well as NK cells ex vivo and neutrophil functions. Methods We investigated the association of OSA with potential alterations in 14 Th1/Th2 and inflammatory cytokines and chemokines, CD4 and CD8 T cells, NK cells, and the NADPH oxidase activation and phagocytic functions in neutrophils. Results Our results suggest that the increase in CD4 T cell frequency in OSA is associated with an increased expression of the nuclear protein Ki67 (p < 0.05; power > 0.8), and is correlated with the levels of IL-1β (p < 0.05; power > 0.8). The levels of IL-1β as well as IL-6 showed a potential increase, while the levels of IFN-γ (p < 0.05; power > 0.8) and the ratio IFN-γ/IL-4 in the blood were possibly decreased in OSA. Additionally, we observed a potential increase in the expression of Ki67 in CD8hi and CD8lo NK cells (p < 0.05; power > 0.8). Our results also suggest that neutrophils have a decreased capacity to phagocytose bacteria and activate NADPH oxidase in OSA patients (p < 0.05; power > 0.8). Conclusion OSA may be associated with inflammatory and pro-Th2 immune responses, an increased proliferative potential of NK and CD4 T cells and a decreased capacity of neutrophils to phagocytose bacteria and produce ROS.

AB - Background There are contradictory reports on the effects of obstructive sleep apnea (OSA) on the immune system. In order to clarify the effect of OSA on the different components of the immune system, we studied the association of OSA with changes in cytokine and chemokine levels, proliferative patterns of CD4 and CD8 T lymphocytes as well as NK cells ex vivo and neutrophil functions. Methods We investigated the association of OSA with potential alterations in 14 Th1/Th2 and inflammatory cytokines and chemokines, CD4 and CD8 T cells, NK cells, and the NADPH oxidase activation and phagocytic functions in neutrophils. Results Our results suggest that the increase in CD4 T cell frequency in OSA is associated with an increased expression of the nuclear protein Ki67 (p < 0.05; power > 0.8), and is correlated with the levels of IL-1β (p < 0.05; power > 0.8). The levels of IL-1β as well as IL-6 showed a potential increase, while the levels of IFN-γ (p < 0.05; power > 0.8) and the ratio IFN-γ/IL-4 in the blood were possibly decreased in OSA. Additionally, we observed a potential increase in the expression of Ki67 in CD8hi and CD8lo NK cells (p < 0.05; power > 0.8). Our results also suggest that neutrophils have a decreased capacity to phagocytose bacteria and activate NADPH oxidase in OSA patients (p < 0.05; power > 0.8). Conclusion OSA may be associated with inflammatory and pro-Th2 immune responses, an increased proliferative potential of NK and CD4 T cells and a decreased capacity of neutrophils to phagocytose bacteria and produce ROS.

KW - Cytokines

KW - Inflammation

KW - Neutrophils

KW - NK cells

KW - Sleep apnea

KW - Th1/Th2

UR - http://www.scopus.com/inward/record.url?scp=85028750182&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028750182&partnerID=8YFLogxK

U2 - 10.1016/j.imlet.2017.08.009

DO - 10.1016/j.imlet.2017.08.009

M3 - Article

VL - 190

SP - 272

EP - 278

JO - Immunology Letters

JF - Immunology Letters

SN - 0165-2478

ER -