All trans retinoic acid in acute promyelocytic leukaemia

Case series and review of literature

I. A. Burney, G. N. Kakepoto, T. Siddiqui, M. Khurshid

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Over the past few years All Trans-Retinoic Acid (ATRA) has been increasingly used to induce remission in Acute Promyelocytic Leukaemia (APL). ATRA is thought to restore the structural integrity of the nuclear bodies which are disrupted by the transcribed chimeric protein (APL-RARα) formed as a result of a specific non-random chromosomal translocation (15:17). Six patients of APL with ATRA were treated at a dose of 45 mg/m2 orally. There were five female and one male patient. Five patients presented with pancytopenia while all had a picture of disseminated intravascular coagulation (DIC). Four out of six patients entered into complete remission either on ATRA alone or with the addition of cytotoxic chemotherapy. The other two patients developed serious side effects and the treatment with ATRA had to be stopped. One of these patients subsequently entered into remission with standard chemotherapy. The mean time to remission was 39 days. Since ATRA does not induce cytotoxicity, the problem of marrow suppression and exacerbation of DIC were largely alleviated. The patients remained at home for the most part of their treatment. Relevant literature is reviewed.

Original languageEnglish
Pages (from-to)119-121
Number of pages3
JournalJournal of the College of Physicians and Surgeons Pakistan
Volume8
Issue number3
Publication statusPublished - 1998

Fingerprint

Acute Promyelocytic Leukemia
Tretinoin
Disseminated Intravascular Coagulation
Drug Therapy
Genetic Translocation
Pancytopenia
Bone Marrow
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

All trans retinoic acid in acute promyelocytic leukaemia : Case series and review of literature. / Burney, I. A.; Kakepoto, G. N.; Siddiqui, T.; Khurshid, M.

In: Journal of the College of Physicians and Surgeons Pakistan, Vol. 8, No. 3, 1998, p. 119-121.

Research output: Contribution to journalArticle

@article{e1629d215cc24ab5bc0354f69bacf396,
title = "All trans retinoic acid in acute promyelocytic leukaemia: Case series and review of literature",
abstract = "Over the past few years All Trans-Retinoic Acid (ATRA) has been increasingly used to induce remission in Acute Promyelocytic Leukaemia (APL). ATRA is thought to restore the structural integrity of the nuclear bodies which are disrupted by the transcribed chimeric protein (APL-RARα) formed as a result of a specific non-random chromosomal translocation (15:17). Six patients of APL with ATRA were treated at a dose of 45 mg/m2 orally. There were five female and one male patient. Five patients presented with pancytopenia while all had a picture of disseminated intravascular coagulation (DIC). Four out of six patients entered into complete remission either on ATRA alone or with the addition of cytotoxic chemotherapy. The other two patients developed serious side effects and the treatment with ATRA had to be stopped. One of these patients subsequently entered into remission with standard chemotherapy. The mean time to remission was 39 days. Since ATRA does not induce cytotoxicity, the problem of marrow suppression and exacerbation of DIC were largely alleviated. The patients remained at home for the most part of their treatment. Relevant literature is reviewed.",
author = "Burney, {I. A.} and Kakepoto, {G. N.} and T. Siddiqui and M. Khurshid",
year = "1998",
language = "English",
volume = "8",
pages = "119--121",
journal = "Journal of the College of Physicians and Surgeons--Pakistan : JCPSP",
issn = "1022-386X",
publisher = "College of Physicians and Surgeons Pakistan",
number = "3",

}

TY - JOUR

T1 - All trans retinoic acid in acute promyelocytic leukaemia

T2 - Case series and review of literature

AU - Burney, I. A.

AU - Kakepoto, G. N.

AU - Siddiqui, T.

AU - Khurshid, M.

PY - 1998

Y1 - 1998

N2 - Over the past few years All Trans-Retinoic Acid (ATRA) has been increasingly used to induce remission in Acute Promyelocytic Leukaemia (APL). ATRA is thought to restore the structural integrity of the nuclear bodies which are disrupted by the transcribed chimeric protein (APL-RARα) formed as a result of a specific non-random chromosomal translocation (15:17). Six patients of APL with ATRA were treated at a dose of 45 mg/m2 orally. There were five female and one male patient. Five patients presented with pancytopenia while all had a picture of disseminated intravascular coagulation (DIC). Four out of six patients entered into complete remission either on ATRA alone or with the addition of cytotoxic chemotherapy. The other two patients developed serious side effects and the treatment with ATRA had to be stopped. One of these patients subsequently entered into remission with standard chemotherapy. The mean time to remission was 39 days. Since ATRA does not induce cytotoxicity, the problem of marrow suppression and exacerbation of DIC were largely alleviated. The patients remained at home for the most part of their treatment. Relevant literature is reviewed.

AB - Over the past few years All Trans-Retinoic Acid (ATRA) has been increasingly used to induce remission in Acute Promyelocytic Leukaemia (APL). ATRA is thought to restore the structural integrity of the nuclear bodies which are disrupted by the transcribed chimeric protein (APL-RARα) formed as a result of a specific non-random chromosomal translocation (15:17). Six patients of APL with ATRA were treated at a dose of 45 mg/m2 orally. There were five female and one male patient. Five patients presented with pancytopenia while all had a picture of disseminated intravascular coagulation (DIC). Four out of six patients entered into complete remission either on ATRA alone or with the addition of cytotoxic chemotherapy. The other two patients developed serious side effects and the treatment with ATRA had to be stopped. One of these patients subsequently entered into remission with standard chemotherapy. The mean time to remission was 39 days. Since ATRA does not induce cytotoxicity, the problem of marrow suppression and exacerbation of DIC were largely alleviated. The patients remained at home for the most part of their treatment. Relevant literature is reviewed.

UR - http://www.scopus.com/inward/record.url?scp=0031829620&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031829620&partnerID=8YFLogxK

M3 - Article

VL - 8

SP - 119

EP - 121

JO - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

JF - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

SN - 1022-386X

IS - 3

ER -