Airway resistance, inflammation and oxidative stress following exposure to diesel exhaust particle in angiotensin II-induced hypertension in mice

Abderrahim Nemmar; Deepa Subramaniyan; Shaheen Zia; Javed Yasin; Badreldin H. Ali

doi:10.1016/j.tox.2011.12.009

Airway resistance, inflammation and oxidative stress following exposure to diesel exhaust particle in angiotensin II-induced hypertension in mice

Abderrahim Nemmar^*, Deepa Subramaniyan, Shaheen Zia, Javed Yasin, Badreldin H. Ali

^*Corresponding author for this work

Pharmacology & Clinical Pharmacy

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Exposure to particulate matter is a risk factor for respiratory and cardiovascular diseases. However, the mechanisms underlying these effects are not well understood. Here, we compared the impact of diesel exhaust particles (DEP) on airway resistance, inflammation and oxidative stress in normal mice, or mice made hypertensive by implanting osmotic minipump infusing angiotensin II. On day 13 after the onset of infusion, angiotensin II induced significant increase in heart rate (P

Original language	English
Pages (from-to)	162-168
Number of pages	7
Journal	Toxicology
Volume	292
Issue number	2-3
DOIs	https://doi.org/10.1016/j.tox.2011.12.009
Publication status	Published - Feb 26 2012

Keywords

Air pollution
Airway resistance
Diesel exhaust particles
Hypertension
Lung inflammation

ASJC Scopus subject areas

Toxicology

Access to Document

10.1016/j.tox.2011.12.009

Fingerprint Dive into the research topics of 'Airway resistance, inflammation and oxidative stress following exposure to diesel exhaust particle in angiotensin II-induced hypertension in mice'. Together they form a unique fingerprint.

Cite this

@article{92360226bac045ea8bfa9268e5e47f42,

title = "Airway resistance, inflammation and oxidative stress following exposure to diesel exhaust particle in angiotensin II-induced hypertension in mice",

abstract = "Exposure to particulate matter is a risk factor for respiratory and cardiovascular diseases. However, the mechanisms underlying these effects are not well understood. Here, we compared the impact of diesel exhaust particles (DEP) on airway resistance, inflammation and oxidative stress in normal mice, or mice made hypertensive by implanting osmotic minipump infusing angiotensin II. On day 13 after the onset of infusion, angiotensin II induced significant increase in heart rate (P",

keywords = "Air pollution, Airway resistance, Diesel exhaust particles, Hypertension, Lung inflammation",

author = "Abderrahim Nemmar and Deepa Subramaniyan and Shaheen Zia and Javed Yasin and Ali, {Badreldin H.}",

year = "2012",

month = feb,

day = "26",

doi = "10.1016/j.tox.2011.12.009",

language = "English",

volume = "292",

pages = "162--168",

journal = "Toxicology",

issn = "0300-483X",

publisher = "Elsevier Ireland Ltd",

number = "2-3",

}

TY - JOUR

T1 - Airway resistance, inflammation and oxidative stress following exposure to diesel exhaust particle in angiotensin II-induced hypertension in mice

AU - Nemmar, Abderrahim

AU - Subramaniyan, Deepa

AU - Zia, Shaheen

AU - Yasin, Javed

AU - Ali, Badreldin H.

PY - 2012/2/26

Y1 - 2012/2/26

N2 - Exposure to particulate matter is a risk factor for respiratory and cardiovascular diseases. However, the mechanisms underlying these effects are not well understood. Here, we compared the impact of diesel exhaust particles (DEP) on airway resistance, inflammation and oxidative stress in normal mice, or mice made hypertensive by implanting osmotic minipump infusing angiotensin II. On day 13 after the onset of infusion, angiotensin II induced significant increase in heart rate (P

AB - Exposure to particulate matter is a risk factor for respiratory and cardiovascular diseases. However, the mechanisms underlying these effects are not well understood. Here, we compared the impact of diesel exhaust particles (DEP) on airway resistance, inflammation and oxidative stress in normal mice, or mice made hypertensive by implanting osmotic minipump infusing angiotensin II. On day 13 after the onset of infusion, angiotensin II induced significant increase in heart rate (P

KW - Air pollution

KW - Airway resistance

KW - Diesel exhaust particles

KW - Hypertension

KW - Lung inflammation

UR - http://www.scopus.com/inward/record.url?scp=84856089135&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856089135&partnerID=8YFLogxK

U2 - 10.1016/j.tox.2011.12.009

DO - 10.1016/j.tox.2011.12.009

M3 - Article

C2 - 22214961

AN - SCOPUS:84856089135

VL - 292

SP - 162

EP - 168

JO - Toxicology

JF - Toxicology

SN - 0300-483X

IS - 2-3

ER -

Airway resistance, inflammation and oxidative stress following exposure to diesel exhaust particle in angiotensin II-induced hypertension in mice

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this