Airway resistance, inflammation and oxidative stress following exposure to diesel exhaust particle in angiotensin II-induced hypertension in mice

Abderrahim Nemmar, Deepa Subramaniyan, Shaheen Zia, Javed Yasin, Badreldin H. Ali

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Exposure to particulate matter is a risk factor for respiratory and cardiovascular diseases. However, the mechanisms underlying these effects are not well understood. Here, we compared the impact of diesel exhaust particles (DEP) on airway resistance, inflammation and oxidative stress in normal mice, or mice made hypertensive by implanting osmotic minipump infusing angiotensin II. On day 13 after the onset of infusion, angiotensin II induced significant increase in heart rate (P

Original languageEnglish
Pages (from-to)162-168
Number of pages7
JournalToxicology
Volume292
Issue number2-3
DOIs
Publication statusPublished - Feb 26 2012

Keywords

  • Air pollution
  • Airway resistance
  • Diesel exhaust particles
  • Hypertension
  • Lung inflammation

ASJC Scopus subject areas

  • Toxicology

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