Airway resistance, inflammation and oxidative stress following exposure to diesel exhaust particle in angiotensin II-induced hypertension in mice

Abderrahim Nemmar; Deepa Subramaniyan; Shaheen Zia; Javed Yasin; Badreldin H. Ali

doi:10.1016/j.tox.2011.12.009

Airway resistance, inflammation and oxidative stress following exposure to diesel exhaust particle in angiotensin II-induced hypertension in mice

Abderrahim Nemmar^*, Deepa Subramaniyan, Shaheen Zia, Javed Yasin, Badreldin H. Ali

^*Corresponding author for this work

Pharmacology & Clinical Pharmacy

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Exposure to particulate matter is a risk factor for respiratory and cardiovascular diseases. However, the mechanisms underlying these effects are not well understood. Here, we compared the impact of diesel exhaust particles (DEP) on airway resistance, inflammation and oxidative stress in normal mice, or mice made hypertensive by implanting osmotic minipump infusing angiotensin II. On day 13 after the onset of infusion, angiotensin II induced significant increase in heart rate (P

Original language	English
Pages (from-to)	162-168
Number of pages	7
Journal	Toxicology
Volume	292
Issue number	2-3
DOIs	https://doi.org/10.1016/j.tox.2011.12.009
Publication status	Published - Feb 26 2012

Keywords

Air pollution
Airway resistance
Diesel exhaust particles
Hypertension
Lung inflammation

ASJC Scopus subject areas

Toxicology

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10.1016/j.tox.2011.12.009

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abstract = "Exposure to particulate matter is a risk factor for respiratory and cardiovascular diseases. However, the mechanisms underlying these effects are not well understood. Here, we compared the impact of diesel exhaust particles (DEP) on airway resistance, inflammation and oxidative stress in normal mice, or mice made hypertensive by implanting osmotic minipump infusing angiotensin II. On day 13 after the onset of infusion, angiotensin II induced significant increase in heart rate (P",

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AU - Subramaniyan, Deepa

AU - Zia, Shaheen

AU - Yasin, Javed

AU - Ali, Badreldin H.

PY - 2012/2/26

Y1 - 2012/2/26

N2 - Exposure to particulate matter is a risk factor for respiratory and cardiovascular diseases. However, the mechanisms underlying these effects are not well understood. Here, we compared the impact of diesel exhaust particles (DEP) on airway resistance, inflammation and oxidative stress in normal mice, or mice made hypertensive by implanting osmotic minipump infusing angiotensin II. On day 13 after the onset of infusion, angiotensin II induced significant increase in heart rate (P

AB - Exposure to particulate matter is a risk factor for respiratory and cardiovascular diseases. However, the mechanisms underlying these effects are not well understood. Here, we compared the impact of diesel exhaust particles (DEP) on airway resistance, inflammation and oxidative stress in normal mice, or mice made hypertensive by implanting osmotic minipump infusing angiotensin II. On day 13 after the onset of infusion, angiotensin II induced significant increase in heart rate (P

KW - Air pollution

KW - Airway resistance

KW - Diesel exhaust particles

KW - Hypertension

KW - Lung inflammation

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Airway resistance, inflammation and oxidative stress following exposure to diesel exhaust particle in angiotensin II-induced hypertension in mice

Abstract

Keywords

ASJC Scopus subject areas

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