Abstract
Exposure to particulate matter is a risk factor for respiratory and cardiovascular diseases. However, the mechanisms underlying these effects are not well understood. Here, we compared the impact of diesel exhaust particles (DEP) on airway resistance, inflammation and oxidative stress in normal mice, or mice made hypertensive by implanting osmotic minipump infusing angiotensin II. On day 13 after the onset of infusion, angiotensin II induced significant increase in heart rate (P
Original language | English |
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Pages (from-to) | 162-168 |
Number of pages | 7 |
Journal | Toxicology |
Volume | 292 |
Issue number | 2-3 |
DOIs | |
Publication status | Published - Feb 26 2012 |
Keywords
- Air pollution
- Airway resistance
- Diesel exhaust particles
- Hypertension
- Lung inflammation
ASJC Scopus subject areas
- Toxicology