Abstract
Exposure to particulate matter is a risk factor for respiratory and cardiovascular diseases. However, the mechanisms underlying these effects are not well understood. Here, we compared the impact of diesel exhaust particles (DEP) on airway resistance, inflammation and oxidative stress in normal mice, or mice made hypertensive by implanting osmotic minipump infusing angiotensin II. On day 13 after the onset of infusion, angiotensin II induced significant increase in heart rate (P
| Original language | English |
|---|---|
| Pages (from-to) | 162-168 |
| Number of pages | 7 |
| Journal | Toxicology |
| Volume | 292 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - Feb 26 2012 |
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Keywords
- Air pollution
- Airway resistance
- Diesel exhaust particles
- Hypertension
- Lung inflammation
ASJC Scopus subject areas
- Toxicology
Cite this
Airway resistance, inflammation and oxidative stress following exposure to diesel exhaust particle in angiotensin II-induced hypertension in mice. / Nemmar, Abderrahim; Subramaniyan, Deepa; Zia, Shaheen; Yasin, Javed; Ali, Badreldin H.
In: Toxicology, Vol. 292, No. 2-3, 26.02.2012, p. 162-168.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Airway resistance, inflammation and oxidative stress following exposure to diesel exhaust particle in angiotensin II-induced hypertension in mice
AU - Nemmar, Abderrahim
AU - Subramaniyan, Deepa
AU - Zia, Shaheen
AU - Yasin, Javed
AU - Ali, Badreldin H.
PY - 2012/2/26
Y1 - 2012/2/26
N2 - Exposure to particulate matter is a risk factor for respiratory and cardiovascular diseases. However, the mechanisms underlying these effects are not well understood. Here, we compared the impact of diesel exhaust particles (DEP) on airway resistance, inflammation and oxidative stress in normal mice, or mice made hypertensive by implanting osmotic minipump infusing angiotensin II. On day 13 after the onset of infusion, angiotensin II induced significant increase in heart rate (P
AB - Exposure to particulate matter is a risk factor for respiratory and cardiovascular diseases. However, the mechanisms underlying these effects are not well understood. Here, we compared the impact of diesel exhaust particles (DEP) on airway resistance, inflammation and oxidative stress in normal mice, or mice made hypertensive by implanting osmotic minipump infusing angiotensin II. On day 13 after the onset of infusion, angiotensin II induced significant increase in heart rate (P
KW - Air pollution
KW - Airway resistance
KW - Diesel exhaust particles
KW - Hypertension
KW - Lung inflammation
UR - http://www.scopus.com/inward/record.url?scp=84856089135&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856089135&partnerID=8YFLogxK
U2 - 10.1016/j.tox.2011.12.009
DO - 10.1016/j.tox.2011.12.009
M3 - Article
C2 - 22214961
AN - SCOPUS:84856089135
VL - 292
SP - 162
EP - 168
JO - Toxicology
JF - Toxicology
SN - 0300-483X
IS - 2-3
ER -