Agreement of histopathological findings of preoperative uterine curettage and hysterectomy specimens

Impact of time factor and hormonal therapy

Reda A. Hemida, Abd Elhady Zayed, Asem Shalaby, Hosam Goda, Muhammad Fawzy, Abdel Aziz El Refaeey

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objectives. To study the agreement of preoperative curettage and definitive histology after hysterectomy as well as the correlation of time factor and hormonal therapy to this agreement. Methods. This retrospective study was done in the Departments of Obstetrics and Gynecology and Pathology, Faculty of Medicine, Mansoura University, Egypt. Pathology reports of patients exposed to dilatation and curettage followed by hysterectomy during the period from May, 2004 to April, 2011were reviewed. Results. We reviewed 83 cases who fulfilled the inclusion criteria. There were non-significant differences between findings of D&C and hysterectomy specimens (P = 0.42). The concordance rate between D&C and hysterectomy was 79.5%. One case of endometrial carcinoma (1.2%), one case of simple endometrial hyperplasia, one case of atrophic endometrium, and two cases of endometrial polyp were diagnosed only after hysterectomy (4.8%). Furthermore, histologic examination of hysterectomy specimens confirmed only 8 of 13 cases (61.5%) of endometrial hyperplasia with atypia. No significant correlation of time factor and hormonal therapy to the agreement between findings of D&C and hysterectomy specimens (P = 0.58 & 0.19 respectively). Conclusion. There was no significant difference between preoperative endometrial histology and hysterectomy specimens (P = 0.41). This agreement had not been significantly affected by time interval and hormonal therapy. Future researches with larger number of cases are needed to confirm or disagree with our findings.

Original languageEnglish
Pages (from-to)165-168
Number of pages4
JournalJournal of Experimental Therapeutics and Oncology
Volume10
Issue number3
Publication statusPublished - 2013

Fingerprint

Curettage
Hysterectomy
Endometrial Hyperplasia
Therapeutics
Histology
Pathology
Dilatation and Curettage
Hospital Obstetrics and Gynecology Department
Egypt
Endometrial Neoplasms
Endometrium
Polyps
Gynecology
Retrospective Studies
Medicine
Research

Keywords

  • Agreement
  • Histology
  • Hysterectomy
  • Uterine curettage

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Cancer Research

Cite this

Agreement of histopathological findings of preoperative uterine curettage and hysterectomy specimens : Impact of time factor and hormonal therapy. / Hemida, Reda A.; Zayed, Abd Elhady; Shalaby, Asem; Goda, Hosam; Fawzy, Muhammad; El Refaeey, Abdel Aziz.

In: Journal of Experimental Therapeutics and Oncology, Vol. 10, No. 3, 2013, p. 165-168.

Research output: Contribution to journalArticle

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abstract = "Objectives. To study the agreement of preoperative curettage and definitive histology after hysterectomy as well as the correlation of time factor and hormonal therapy to this agreement. Methods. This retrospective study was done in the Departments of Obstetrics and Gynecology and Pathology, Faculty of Medicine, Mansoura University, Egypt. Pathology reports of patients exposed to dilatation and curettage followed by hysterectomy during the period from May, 2004 to April, 2011were reviewed. Results. We reviewed 83 cases who fulfilled the inclusion criteria. There were non-significant differences between findings of D&C and hysterectomy specimens (P = 0.42). The concordance rate between D&C and hysterectomy was 79.5{\%}. One case of endometrial carcinoma (1.2{\%}), one case of simple endometrial hyperplasia, one case of atrophic endometrium, and two cases of endometrial polyp were diagnosed only after hysterectomy (4.8{\%}). Furthermore, histologic examination of hysterectomy specimens confirmed only 8 of 13 cases (61.5{\%}) of endometrial hyperplasia with atypia. No significant correlation of time factor and hormonal therapy to the agreement between findings of D&C and hysterectomy specimens (P = 0.58 & 0.19 respectively). Conclusion. There was no significant difference between preoperative endometrial histology and hysterectomy specimens (P = 0.41). This agreement had not been significantly affected by time interval and hormonal therapy. Future researches with larger number of cases are needed to confirm or disagree with our findings.",
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