Agents ameliorating or augmenting experimental gentamicin nephrotoxicity: Some recent research

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

Despite its nephrotoxic potential, the aminoglycoside antibiotic gentamicin (GM) is still considered to be an important agent against life-threatening infections. The goal of reducing or protecting against its nephrotoxicity has attracted much effort and attention during the last decade. This article reviews some of the literature published during the last decade on the effects of agents that ameliorate or augment GM nephrotoxicity. Notable among the ameliorating agents are antioxidant agents. These include different classes of compounds that include beta blockers (e.g. carvedilol), superoxide dismutase mimetic agents (e.g. M40403), hormones (e.g. melatonin), iron chelators (e.g. deferrioxamine), vitamins (vitamin C and E) and medicinal plants (e.g. garlic). Other ameliorating agents include antibiotics (e.g. ceftriaxone), antiplatelet drugs (e.g. trapidil) and Ca++ agents that may augment GM nephrotoxicity include cyclosporin and the Ca ++-channel blocker verapamil.

Original languageEnglish
Pages (from-to)1447-1452
Number of pages6
JournalFood and Chemical Toxicology
Volume41
Issue number11
DOIs
Publication statusPublished - Nov 1 2003

    Fingerprint

Keywords

  • Antioxidants
  • Gentamicin
  • Nephrotoxicity

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this