Agaricus blazei extract abrogates rotenone-induced dopamine depletion and motor deficits by its anti-oxidative and anti-inflammatory properties in Parkinsonic mice

Veerappan Venkatesh Gobi, Srinivasagam Rajasankar, Muthu Ramkumar, Chinnasamy Dhanalakshmi, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Musthafa Mohamed Essa, Ranganathan Chidambaram, Ameer Kalandar

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Neuroinflammation and oxidative damage are the two main malfactors that play an important role in the pathogenesis of experimental and clinical Parkinson’s disease (PD). The current study was aimed to study the possible anti-oxidant and anti-inflammatory effects of the methanolic extract of Agaricus blazei (A. blazei) against rotenone-induced PD in mice. Male Albino mice were randomized and divided into the following groups: control, treated with rotenone (1 mg/kg/day), co-treated with rotenone and A. blazei (50, 100, and 200 mg/kg b.w.), and treated with A. blazei alone (200 mg/kg b.w.). After the end of the experimental period, behavioral studies, biochemical estimations, and protein expression patterns of inflammatory markers were studied. Rotenone treatment exhibited enhanced motor impairments, neurochemical deficits, oxidative stress, and inflammation, whereas oral administration of A. blazei extract attenuated the above-said indices. Even though further research is needed to prove its efficacy in clinical studies, the results of our study concluded that A. blazei extract offers a promising and new therapeutic lead for treatment of PD.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalNutritional Neuroscience
DOIs
Publication statusAccepted/In press - Jun 21 2017

Fingerprint

Agaricus
Rotenone
Dopamine
Anti-Inflammatory Agents
Parkinson Disease
Parkinsonian Disorders
Oxidants
Oral Administration
Oxidative Stress
Therapeutics
Inflammation
Control Groups
Research
Proteins

Keywords

  • Agaricus blazei
  • Dopamine
  • Neurodegenerative disease
  • Neuroinflammation
  • Oxidative stress

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Venkatesh Gobi, V., Rajasankar, S., Ramkumar, M., Dhanalakshmi, C., Manivasagam, T., Justin Thenmozhi, A., ... Kalandar, A. (Accepted/In press). Agaricus blazei extract abrogates rotenone-induced dopamine depletion and motor deficits by its anti-oxidative and anti-inflammatory properties in Parkinsonic mice. Nutritional Neuroscience, 1-10. https://doi.org/10.1080/1028415X.2017.1337290

Agaricus blazei extract abrogates rotenone-induced dopamine depletion and motor deficits by its anti-oxidative and anti-inflammatory properties in Parkinsonic mice. / Venkatesh Gobi, Veerappan; Rajasankar, Srinivasagam; Ramkumar, Muthu; Dhanalakshmi, Chinnasamy; Manivasagam, Thamilarasan; Justin Thenmozhi, Arokiasamy; Essa, Musthafa Mohamed; Chidambaram, Ranganathan; Kalandar, Ameer.

In: Nutritional Neuroscience, 21.06.2017, p. 1-10.

Research output: Contribution to journalArticle

Venkatesh Gobi, Veerappan ; Rajasankar, Srinivasagam ; Ramkumar, Muthu ; Dhanalakshmi, Chinnasamy ; Manivasagam, Thamilarasan ; Justin Thenmozhi, Arokiasamy ; Essa, Musthafa Mohamed ; Chidambaram, Ranganathan ; Kalandar, Ameer. / Agaricus blazei extract abrogates rotenone-induced dopamine depletion and motor deficits by its anti-oxidative and anti-inflammatory properties in Parkinsonic mice. In: Nutritional Neuroscience. 2017 ; pp. 1-10.
@article{81a02c806d7c4364a84323347e9f9d92,
title = "Agaricus blazei extract abrogates rotenone-induced dopamine depletion and motor deficits by its anti-oxidative and anti-inflammatory properties in Parkinsonic mice",
abstract = "Neuroinflammation and oxidative damage are the two main malfactors that play an important role in the pathogenesis of experimental and clinical Parkinson’s disease (PD). The current study was aimed to study the possible anti-oxidant and anti-inflammatory effects of the methanolic extract of Agaricus blazei (A. blazei) against rotenone-induced PD in mice. Male Albino mice were randomized and divided into the following groups: control, treated with rotenone (1 mg/kg/day), co-treated with rotenone and A. blazei (50, 100, and 200 mg/kg b.w.), and treated with A. blazei alone (200 mg/kg b.w.). After the end of the experimental period, behavioral studies, biochemical estimations, and protein expression patterns of inflammatory markers were studied. Rotenone treatment exhibited enhanced motor impairments, neurochemical deficits, oxidative stress, and inflammation, whereas oral administration of A. blazei extract attenuated the above-said indices. Even though further research is needed to prove its efficacy in clinical studies, the results of our study concluded that A. blazei extract offers a promising and new therapeutic lead for treatment of PD.",
keywords = "Agaricus blazei, Dopamine, Neurodegenerative disease, Neuroinflammation, Oxidative stress",
author = "{Venkatesh Gobi}, Veerappan and Srinivasagam Rajasankar and Muthu Ramkumar and Chinnasamy Dhanalakshmi and Thamilarasan Manivasagam and {Justin Thenmozhi}, Arokiasamy and Essa, {Musthafa Mohamed} and Ranganathan Chidambaram and Ameer Kalandar",
year = "2017",
month = "6",
day = "21",
doi = "10.1080/1028415X.2017.1337290",
language = "English",
pages = "1--10",
journal = "Nutritional Neuroscience",
issn = "1028-415X",
publisher = "Maney Publishing",

}

TY - JOUR

T1 - Agaricus blazei extract abrogates rotenone-induced dopamine depletion and motor deficits by its anti-oxidative and anti-inflammatory properties in Parkinsonic mice

AU - Venkatesh Gobi, Veerappan

AU - Rajasankar, Srinivasagam

AU - Ramkumar, Muthu

AU - Dhanalakshmi, Chinnasamy

AU - Manivasagam, Thamilarasan

AU - Justin Thenmozhi, Arokiasamy

AU - Essa, Musthafa Mohamed

AU - Chidambaram, Ranganathan

AU - Kalandar, Ameer

PY - 2017/6/21

Y1 - 2017/6/21

N2 - Neuroinflammation and oxidative damage are the two main malfactors that play an important role in the pathogenesis of experimental and clinical Parkinson’s disease (PD). The current study was aimed to study the possible anti-oxidant and anti-inflammatory effects of the methanolic extract of Agaricus blazei (A. blazei) against rotenone-induced PD in mice. Male Albino mice were randomized and divided into the following groups: control, treated with rotenone (1 mg/kg/day), co-treated with rotenone and A. blazei (50, 100, and 200 mg/kg b.w.), and treated with A. blazei alone (200 mg/kg b.w.). After the end of the experimental period, behavioral studies, biochemical estimations, and protein expression patterns of inflammatory markers were studied. Rotenone treatment exhibited enhanced motor impairments, neurochemical deficits, oxidative stress, and inflammation, whereas oral administration of A. blazei extract attenuated the above-said indices. Even though further research is needed to prove its efficacy in clinical studies, the results of our study concluded that A. blazei extract offers a promising and new therapeutic lead for treatment of PD.

AB - Neuroinflammation and oxidative damage are the two main malfactors that play an important role in the pathogenesis of experimental and clinical Parkinson’s disease (PD). The current study was aimed to study the possible anti-oxidant and anti-inflammatory effects of the methanolic extract of Agaricus blazei (A. blazei) against rotenone-induced PD in mice. Male Albino mice were randomized and divided into the following groups: control, treated with rotenone (1 mg/kg/day), co-treated with rotenone and A. blazei (50, 100, and 200 mg/kg b.w.), and treated with A. blazei alone (200 mg/kg b.w.). After the end of the experimental period, behavioral studies, biochemical estimations, and protein expression patterns of inflammatory markers were studied. Rotenone treatment exhibited enhanced motor impairments, neurochemical deficits, oxidative stress, and inflammation, whereas oral administration of A. blazei extract attenuated the above-said indices. Even though further research is needed to prove its efficacy in clinical studies, the results of our study concluded that A. blazei extract offers a promising and new therapeutic lead for treatment of PD.

KW - Agaricus blazei

KW - Dopamine

KW - Neurodegenerative disease

KW - Neuroinflammation

KW - Oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=85021126616&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021126616&partnerID=8YFLogxK

U2 - 10.1080/1028415X.2017.1337290

DO - 10.1080/1028415X.2017.1337290

M3 - Article

SP - 1

EP - 10

JO - Nutritional Neuroscience

JF - Nutritional Neuroscience

SN - 1028-415X

ER -