Advances in the methodologies for the analysis of acute kidney injury biomarkers

Research output: Contribution to journalArticle

Abstract

The kidneys control homeostasis by regulating plasma volume and hormone secretion and acid-base balance. These are delicate organs and, sometimes are weakened due to many kidney diseases and use of some toxins and excess drugs. Acute kidney injury (AKI) is an important cause of renal failure. The serum creatinine and blood urea are classical kidney biomarkers. New kidney acute injury biomarkers i.e. acute kidney injury (AKI) biomarkers are early indicators of kidney diseases, which may be used to save the lives of the patients. Therefore, analysis of AKI is essential and urgent issue in urology. The analysis of AKI biomarkers is reviewed. The article describes the-state-of-the art of the analyses of AKI biomarkers in urine, blood and breath samples. The attempts are made to discuss the sample handlings and analyses techniques. The analyses techniques discussed are chromatography, ELISA, NMR, nano technology and others. Some recent patents (2014-2015) have also been reviewed. Most of the patents available used immune assays detections of AKI biomarkers; except few where chromatography was used. Besides, the efforts have also been made to discuss correlation among AKIs biomarkers, serum creatinine and blood urea nitrogen. Additionally, the current and future developments are also highlighted in AKI biomarkers analyses.

Original languageEnglish
Pages (from-to)81-92
Number of pages12
JournalRecent Patents on Biomarkers
Volume5
Issue number2
Publication statusPublished - Aug 1 2015

Fingerprint

Biomarkers
Acute Kidney Injury
Blood
Patents
Kidney Diseases
Chromatography
Urea
Creatinine
Urology
Kidney
Acid-Base Equilibrium
Plasma Volume
Blood Urea Nitrogen
Serum
Nanotechnology
Renal Insufficiency
Assays
Homeostasis
Nitrogen
Enzyme-Linked Immunosorbent Assay

Keywords

  • Acute kidney injury
  • Biomarkers
  • Current and future developments
  • Patents
  • Sample handlings
  • Techniques

ASJC Scopus subject areas

  • Molecular Medicine
  • Clinical Biochemistry

Cite this

Advances in the methodologies for the analysis of acute kidney injury biomarkers. / Za’abi, Mohammed Al; Ali, Badreldin H.; Ali, Imran.

In: Recent Patents on Biomarkers, Vol. 5, No. 2, 01.08.2015, p. 81-92.

Research output: Contribution to journalArticle

@article{947641ecdd324a7f92593c3bd380abba,
title = "Advances in the methodologies for the analysis of acute kidney injury biomarkers",
abstract = "The kidneys control homeostasis by regulating plasma volume and hormone secretion and acid-base balance. These are delicate organs and, sometimes are weakened due to many kidney diseases and use of some toxins and excess drugs. Acute kidney injury (AKI) is an important cause of renal failure. The serum creatinine and blood urea are classical kidney biomarkers. New kidney acute injury biomarkers i.e. acute kidney injury (AKI) biomarkers are early indicators of kidney diseases, which may be used to save the lives of the patients. Therefore, analysis of AKI is essential and urgent issue in urology. The analysis of AKI biomarkers is reviewed. The article describes the-state-of-the art of the analyses of AKI biomarkers in urine, blood and breath samples. The attempts are made to discuss the sample handlings and analyses techniques. The analyses techniques discussed are chromatography, ELISA, NMR, nano technology and others. Some recent patents (2014-2015) have also been reviewed. Most of the patents available used immune assays detections of AKI biomarkers; except few where chromatography was used. Besides, the efforts have also been made to discuss correlation among AKIs biomarkers, serum creatinine and blood urea nitrogen. Additionally, the current and future developments are also highlighted in AKI biomarkers analyses.",
keywords = "Acute kidney injury, Biomarkers, Current and future developments, Patents, Sample handlings, Techniques",
author = "Za’abi, {Mohammed Al} and Ali, {Badreldin H.} and Imran Ali",
year = "2015",
month = "8",
day = "1",
language = "English",
volume = "5",
pages = "81--92",
journal = "Current Biomarkers",
issn = "2468-4228",
publisher = "Bentham Science Publishers B.V.",
number = "2",

}

TY - JOUR

T1 - Advances in the methodologies for the analysis of acute kidney injury biomarkers

AU - Za’abi, Mohammed Al

AU - Ali, Badreldin H.

AU - Ali, Imran

PY - 2015/8/1

Y1 - 2015/8/1

N2 - The kidneys control homeostasis by regulating plasma volume and hormone secretion and acid-base balance. These are delicate organs and, sometimes are weakened due to many kidney diseases and use of some toxins and excess drugs. Acute kidney injury (AKI) is an important cause of renal failure. The serum creatinine and blood urea are classical kidney biomarkers. New kidney acute injury biomarkers i.e. acute kidney injury (AKI) biomarkers are early indicators of kidney diseases, which may be used to save the lives of the patients. Therefore, analysis of AKI is essential and urgent issue in urology. The analysis of AKI biomarkers is reviewed. The article describes the-state-of-the art of the analyses of AKI biomarkers in urine, blood and breath samples. The attempts are made to discuss the sample handlings and analyses techniques. The analyses techniques discussed are chromatography, ELISA, NMR, nano technology and others. Some recent patents (2014-2015) have also been reviewed. Most of the patents available used immune assays detections of AKI biomarkers; except few where chromatography was used. Besides, the efforts have also been made to discuss correlation among AKIs biomarkers, serum creatinine and blood urea nitrogen. Additionally, the current and future developments are also highlighted in AKI biomarkers analyses.

AB - The kidneys control homeostasis by regulating plasma volume and hormone secretion and acid-base balance. These are delicate organs and, sometimes are weakened due to many kidney diseases and use of some toxins and excess drugs. Acute kidney injury (AKI) is an important cause of renal failure. The serum creatinine and blood urea are classical kidney biomarkers. New kidney acute injury biomarkers i.e. acute kidney injury (AKI) biomarkers are early indicators of kidney diseases, which may be used to save the lives of the patients. Therefore, analysis of AKI is essential and urgent issue in urology. The analysis of AKI biomarkers is reviewed. The article describes the-state-of-the art of the analyses of AKI biomarkers in urine, blood and breath samples. The attempts are made to discuss the sample handlings and analyses techniques. The analyses techniques discussed are chromatography, ELISA, NMR, nano technology and others. Some recent patents (2014-2015) have also been reviewed. Most of the patents available used immune assays detections of AKI biomarkers; except few where chromatography was used. Besides, the efforts have also been made to discuss correlation among AKIs biomarkers, serum creatinine and blood urea nitrogen. Additionally, the current and future developments are also highlighted in AKI biomarkers analyses.

KW - Acute kidney injury

KW - Biomarkers

KW - Current and future developments

KW - Patents

KW - Sample handlings

KW - Techniques

UR - http://www.scopus.com/inward/record.url?scp=84977904360&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84977904360&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84977904360

VL - 5

SP - 81

EP - 92

JO - Current Biomarkers

JF - Current Biomarkers

SN - 2468-4228

IS - 2

ER -