Acute toxicity of samorin (Isometamidium chloride) in rabbits

B. H. Ali, E. M. Haroun

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

1. Oral administration of samorin (isometamidium chloride) to rabbits in single oral doses of 6.25, 12.5, 25 and 50 mg/kg produced signs of toxicity which were dose-dependent. These were restlessness, hyperaesthesia, tremors, convulsions and finally death. 2. Post mortem examination revealed fatty change, congestion and haemorrhage in many organs. Histopathological examination of liver, brain, kidneys and lungs showed severe circulatory changes and cellular damage. Measurement of serum constituents confirmed the presence of hepatic and renal damage. 3. Samorin produced a marked fall in the erythrocyte count and the haematocrit values of all the treated rabbits, and in doses of 25 and 50 mg/kg it also increased the osmotic fragility of the erythrocytes.

Original languageEnglish
Pages (from-to)419-423
Number of pages5
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume78
Issue number2
DOIs
Publication statusPublished - 1984

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Rabbits
Hyperesthesia
Osmotic Fragility
Kidney
Psychomotor Agitation
Erythrocyte Count
Liver
Tremor
Hematocrit
Oral Administration
Autopsy
Seizures
Erythrocytes
Hemorrhage
Lung
Brain
Serum
isometamidium chloride

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

Acute toxicity of samorin (Isometamidium chloride) in rabbits. / Ali, B. H.; Haroun, E. M.

In: Comparative Biochemistry and Physiology. Part C, Comparative, Vol. 78, No. 2, 1984, p. 419-423.

Research output: Contribution to journalArticle

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