Acute myeloid leukemia in children in Pakistan: an audit.

S. Zaki, I. A. Burney, M. Khurshid

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

OBJECTIVE: To see the clinical features and treatment of children with Acute Myeloid Leukemia (AML) in Pakistan. SETTING: Tertiary referral at a specialist Hematology/Oncology center. METHODS: Retrospective, chart-based review of children (less than 14 years) admitted to the hospital with a diagnosis of AML between January 1987 and August 1997. RESULTS: A total of 23 patients were admitted. There were 18 males and 5 females. The mean age was 8 +/- 5 years. M3 was the commonest morphological subtype (43%). Twenty-two percent of the patients presented with hyperleucocytosis (TLC > 100 x 10(9)/L) and 95% with an elevated LDH (> 548 IU/L). Pneumonia at presentation was seen in 29%. Of 23 patients 14 were evaluable for responses. Six patients died early (43%); 3 before starting the chemotherapy and 3 during the induction chemotherapy, 8/11 (73%) patients entered remission. The median survival was 9 months. CONCLUSION: The pediatric patients with acute myeloid leukemia present with advanced disease. There is a high early death rate (within 28 days of diagnosis). The long-term outcome was inferior to that reported in the literature.

Original languageEnglish
Pages (from-to)247-249
Number of pages3
JournalJournal of the Pakistan Medical Association
Volume52
Issue number6
Publication statusPublished - Jun 2002

Fingerprint

Pakistan
Acute Myeloid Leukemia
Induction Chemotherapy
Hematology
Pneumonia
Referral and Consultation
Pediatrics
Drug Therapy
Survival
Mortality

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Acute myeloid leukemia in children in Pakistan : an audit. / Zaki, S.; Burney, I. A.; Khurshid, M.

In: Journal of the Pakistan Medical Association, Vol. 52, No. 6, 06.2002, p. 247-249.

Research output: Contribution to journalArticle

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abstract = "OBJECTIVE: To see the clinical features and treatment of children with Acute Myeloid Leukemia (AML) in Pakistan. SETTING: Tertiary referral at a specialist Hematology/Oncology center. METHODS: Retrospective, chart-based review of children (less than 14 years) admitted to the hospital with a diagnosis of AML between January 1987 and August 1997. RESULTS: A total of 23 patients were admitted. There were 18 males and 5 females. The mean age was 8 +/- 5 years. M3 was the commonest morphological subtype (43{\%}). Twenty-two percent of the patients presented with hyperleucocytosis (TLC > 100 x 10(9)/L) and 95{\%} with an elevated LDH (> 548 IU/L). Pneumonia at presentation was seen in 29{\%}. Of 23 patients 14 were evaluable for responses. Six patients died early (43{\%}); 3 before starting the chemotherapy and 3 during the induction chemotherapy, 8/11 (73{\%}) patients entered remission. The median survival was 9 months. CONCLUSION: The pediatric patients with acute myeloid leukemia present with advanced disease. There is a high early death rate (within 28 days of diagnosis). The long-term outcome was inferior to that reported in the literature.",
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