Acquired inhibitor to factor VIII: Report of two unusual cases

A. V. Pathare; S. Ghamande; S. Fernandes; S. Bhatia; F. Jijina; S. Shetty; K. Ghosh; D. Mohanty

Acquired inhibitor to factor VIII: Report of two unusual cases

A. V. Pathare, S. Ghamande, S. Fernandes, S. Bhatia, F. Jijina, S. Shetty, K. Ghosh, D. Mohanty^*

^*Corresponding author for this work

Haematology

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The present report describes two unusual cases of bleeding due to development of inhibitor against factor VIII. One of the patients was known to have severe haemophilia B (factor IX <1%) and the other, a healthy male of 46 years, spontaneously started to bleed and was found to have developed inhibitors to factor VIII:C along with other autoantibodies. Development of inhibitors to coagulation factors is a serious clinical problem in developed countries and is more so in developing countries where treatment options are often limited.

Original language	English
Pages (from-to)	212-214
Number of pages	3
Journal	Haemophilia
Volume	3
Issue number	3
Publication status	Published - 1997

Keywords

Acquired haemophilia
Autoantibodies
Factor VIII inhibitors

ASJC Scopus subject areas

Hematology

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Cite this

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title = "Acquired inhibitor to factor VIII: Report of two unusual cases",

abstract = "The present report describes two unusual cases of bleeding due to development of inhibitor against factor VIII. One of the patients was known to have severe haemophilia B (factor IX <1%) and the other, a healthy male of 46 years, spontaneously started to bleed and was found to have developed inhibitors to factor VIII:C along with other autoantibodies. Development of inhibitors to coagulation factors is a serious clinical problem in developed countries and is more so in developing countries where treatment options are often limited.",

keywords = "Acquired haemophilia, Autoantibodies, Factor VIII inhibitors",

author = "Pathare, {A. V.} and S. Ghamande and S. Fernandes and S. Bhatia and F. Jijina and S. Shetty and K. Ghosh and D. Mohanty",

year = "1997",

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journal = "Haemophilia",

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T1 - Acquired inhibitor to factor VIII

T2 - Report of two unusual cases

AU - Pathare, A. V.

AU - Ghamande, S.

AU - Fernandes, S.

AU - Bhatia, S.

AU - Jijina, F.

AU - Shetty, S.

AU - Ghosh, K.

AU - Mohanty, D.

PY - 1997

Y1 - 1997

N2 - The present report describes two unusual cases of bleeding due to development of inhibitor against factor VIII. One of the patients was known to have severe haemophilia B (factor IX <1%) and the other, a healthy male of 46 years, spontaneously started to bleed and was found to have developed inhibitors to factor VIII:C along with other autoantibodies. Development of inhibitors to coagulation factors is a serious clinical problem in developed countries and is more so in developing countries where treatment options are often limited.

AB - The present report describes two unusual cases of bleeding due to development of inhibitor against factor VIII. One of the patients was known to have severe haemophilia B (factor IX <1%) and the other, a healthy male of 46 years, spontaneously started to bleed and was found to have developed inhibitors to factor VIII:C along with other autoantibodies. Development of inhibitors to coagulation factors is a serious clinical problem in developed countries and is more so in developing countries where treatment options are often limited.

KW - Acquired haemophilia

KW - Autoantibodies

KW - Factor VIII inhibitors

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