Abstract
This analysis evaluated the effects of deferasirox on liver iron concentration in moderate and heavily iron-overloaded patients with β-thalassaemia from the ESCALATOR trial (n=231). Mean liver iron concentrations (LIC) decreased significantly from 21.1±8.2 to 14.2±12.1mg Fe/g dry weight (dw) at 2yr (P<0.001) in patients with LIC ≥7mg Fe/g dw at baseline; patients with LIC <7mg Fe/g dw maintained these levels over the treatment period. The proportion of patients with LIC <7mg Fe/g dw increased from 9.4% at core baseline to 39.3% by the end of year 2. The results showed that deferasirox enabled therapeutic goals to be achieved, by maintaining LIC in patients with LIC <7mg Fe/g dw at a mean dose of 22.4±5.2mg/kg/d and significantly reducing LIC in patients with LIC ≥7mg Fe/g dw at a mean dose of 25.7±4.2mg/kg/d, along with a manageable safety profile.
Original language | English |
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Pages (from-to) | 349-354 |
Number of pages | 6 |
Journal | European Journal of Haematology |
Volume | 87 |
Issue number | 4 |
DOIs | |
Publication status | Published - Oct 2011 |
Keywords
- Deferasirox
- Efficacy
- Iron chelation therapy
- Iron overload
- β-thalassaemia
ASJC Scopus subject areas
- Hematology