Acetyl Salicylic Acid Alleviates Increased Susceptibility to Thrombosis in Pial Microvessels of Dehydrated Mice

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Abstract

Effect of water deprivation for 1, 2 and 3 days, on blood parameters and photochemically-induced thrombosis in pial microvessels of the mouse were investigated. Blood data of dehydrated mice confirmed hemoconcentration with significant increases in urea, total proteins and cholesterol. The time required for the first platelet aggregate to appear and time to full occlusion in pial arterioles were significantly shorter in dehydrated mice than in control, thus suggesting an increased susceptibility to cerebrovascular thrombosis. The effect of acetyl salicylic acid (ASA), 100 mg/kg (i.p.), in alleviating the accelerated thrombosis in dehydrated mice was also investigated. Mice were deprived of drinking water for a 24-hr period prior to the injection of ASA and the photochemical aggregation procedure. Acetyl salicylic acid significantly prolonged both time to platelet aggregation and to full occlusion of the vessel in dehydrated mice, thus indicating a protective effect.

Original languageEnglish
Pages (from-to)245-248
Number of pages4
JournalJournal of Veterinary Medical Science
Volume56
Issue number2
DOIs
Publication statusPublished - 1994

Fingerprint

Salicylic Acid
aspirin
thrombosis
Microvessels
Thrombosis
mice
Water Deprivation
water deprivation
platelet aggregation
blood
Arterioles
protein aggregates
Platelet Aggregation
Drinking Water
drinking water
protective effect
Urea
Blood Platelets
urea
Cholesterol

Keywords

  • acetyl salicylic acid
  • cerebral
  • dehydration
  • microcirculation
  • thrombosis

ASJC Scopus subject areas

  • veterinary(all)

Cite this

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title = "Acetyl Salicylic Acid Alleviates Increased Susceptibility to Thrombosis in Pial Microvessels of Dehydrated Mice",
abstract = "Effect of water deprivation for 1, 2 and 3 days, on blood parameters and photochemically-induced thrombosis in pial microvessels of the mouse were investigated. Blood data of dehydrated mice confirmed hemoconcentration with significant increases in urea, total proteins and cholesterol. The time required for the first platelet aggregate to appear and time to full occlusion in pial arterioles were significantly shorter in dehydrated mice than in control, thus suggesting an increased susceptibility to cerebrovascular thrombosis. The effect of acetyl salicylic acid (ASA), 100 mg/kg (i.p.), in alleviating the accelerated thrombosis in dehydrated mice was also investigated. Mice were deprived of drinking water for a 24-hr period prior to the injection of ASA and the photochemical aggregation procedure. Acetyl salicylic acid significantly prolonged both time to platelet aggregation and to full occlusion of the vessel in dehydrated mice, thus indicating a protective effect.",
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T1 - Acetyl Salicylic Acid Alleviates Increased Susceptibility to Thrombosis in Pial Microvessels of Dehydrated Mice

AU - Tanira, Musbah O M

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N2 - Effect of water deprivation for 1, 2 and 3 days, on blood parameters and photochemically-induced thrombosis in pial microvessels of the mouse were investigated. Blood data of dehydrated mice confirmed hemoconcentration with significant increases in urea, total proteins and cholesterol. The time required for the first platelet aggregate to appear and time to full occlusion in pial arterioles were significantly shorter in dehydrated mice than in control, thus suggesting an increased susceptibility to cerebrovascular thrombosis. The effect of acetyl salicylic acid (ASA), 100 mg/kg (i.p.), in alleviating the accelerated thrombosis in dehydrated mice was also investigated. Mice were deprived of drinking water for a 24-hr period prior to the injection of ASA and the photochemical aggregation procedure. Acetyl salicylic acid significantly prolonged both time to platelet aggregation and to full occlusion of the vessel in dehydrated mice, thus indicating a protective effect.

AB - Effect of water deprivation for 1, 2 and 3 days, on blood parameters and photochemically-induced thrombosis in pial microvessels of the mouse were investigated. Blood data of dehydrated mice confirmed hemoconcentration with significant increases in urea, total proteins and cholesterol. The time required for the first platelet aggregate to appear and time to full occlusion in pial arterioles were significantly shorter in dehydrated mice than in control, thus suggesting an increased susceptibility to cerebrovascular thrombosis. The effect of acetyl salicylic acid (ASA), 100 mg/kg (i.p.), in alleviating the accelerated thrombosis in dehydrated mice was also investigated. Mice were deprived of drinking water for a 24-hr period prior to the injection of ASA and the photochemical aggregation procedure. Acetyl salicylic acid significantly prolonged both time to platelet aggregation and to full occlusion of the vessel in dehydrated mice, thus indicating a protective effect.

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KW - microcirculation

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