A thirty day course of sodium stibogluconate for treatment of Kala-azar in Nepal

P. Karki, S. Koirala, S. C. Parija, S. G. Hansdak, M. L. Das

Research output: Contribution to journalArticle

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Abstract

Twenty-seven cases of Kala-azar were treated with sodium stibogluconate at a dose of 20 mg/ kg/day for 20 days (group A) and an equal number of cases were treated with the same dose but for a longer duration of 30 days (group B). Clinical and laboratory evaluation of these cases were carried out before and after therapy, during a follow up of cases every month, upto 6 months. Renal and liver function tests and electrocardiography were carried out of monitor any toxic effect of the drug during therapy. The cure rates of patients were 77.78% and 92.59% in group A and B cases respectively. Six and two patients in group A and B respectively were unresponsive to the treatment and showed relapse. Results of the study show that treatment of cases of Kala-azar with sodium stibogluconate in a dosage of 20 mg/kg/day for a longer period of 30 days is effective with a higher cure rate and minimum side effects, for treatment of cases of Kala-azar in this eastern part of Nepal, endemic for the disease.

Original languageEnglish
Pages (from-to)154-158
Number of pages5
JournalSoutheast Asian Journal of Tropical Medicine and Public Health
Volume29
Issue number1
Publication statusPublished - Mar 1998

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Antimony Sodium Gluconate
Nepal
Visceral Leishmaniasis
Endemic Diseases
Poisons
Liver Function Tests
Therapeutics
Electrocardiography
Kidney
Recurrence
Drug Therapy

ASJC Scopus subject areas

  • Medicine(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

A thirty day course of sodium stibogluconate for treatment of Kala-azar in Nepal. / Karki, P.; Koirala, S.; Parija, S. C.; Hansdak, S. G.; Das, M. L.

In: Southeast Asian Journal of Tropical Medicine and Public Health, Vol. 29, No. 1, 03.1998, p. 154-158.

Research output: Contribution to journalArticle

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