A stereospecific synthesis of tetra-substituted chiral piperazines

Raid J. Abdel-Jalil; Raed A. Al-Qawasmeh; Yousef Al-Abed; Wolfgang Voelter

doi:10.1016/S0040-4039(98)01677-3

A stereospecific synthesis of tetra-substituted chiral piperazines

Raid J. Abdel-Jalil, Raed A. Al-Qawasmeh, Yousef Al-Abed, Wolfgang Voelter^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

A one pot reaction of the epoxy triflates 1 or 2 with a variety of N',N'-disubstituted ethylenediamines yields the corresponding chiral piperazine derivatives 3a-e and 4a-e of potential pharmacological interest in high yields.

Original language	English
Pages (from-to)	7703-7704
Number of pages	2
Journal	Tetrahedron Letters
Volume	39
Issue number	42
DOIs	https://doi.org/10.1016/S0040-4039(98)01677-3
Publication status	Published - Oct 15 1998
Externally published	Yes

Keywords

Anhydro sugars
Chiral piperazines
Piperazine derivatives

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(98)01677-3

Cite this

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title = "A stereospecific synthesis of tetra-substituted chiral piperazines",

abstract = "A one pot reaction of the epoxy triflates 1 or 2 with a variety of N',N'-disubstituted ethylenediamines yields the corresponding chiral piperazine derivatives 3a-e and 4a-e of potential pharmacological interest in high yields.",

keywords = "Anhydro sugars, Chiral piperazines, Piperazine derivatives",

author = "Abdel-Jalil, {Raid J.} and Al-Qawasmeh, {Raed A.} and Yousef Al-Abed and Wolfgang Voelter",

year = "1998",

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T1 - A stereospecific synthesis of tetra-substituted chiral piperazines

AU - Abdel-Jalil, Raid J.

AU - Al-Qawasmeh, Raed A.

AU - Al-Abed, Yousef

AU - Voelter, Wolfgang

PY - 1998/10/15

Y1 - 1998/10/15

N2 - A one pot reaction of the epoxy triflates 1 or 2 with a variety of N',N'-disubstituted ethylenediamines yields the corresponding chiral piperazine derivatives 3a-e and 4a-e of potential pharmacological interest in high yields.

AB - A one pot reaction of the epoxy triflates 1 or 2 with a variety of N',N'-disubstituted ethylenediamines yields the corresponding chiral piperazine derivatives 3a-e and 4a-e of potential pharmacological interest in high yields.

KW - Anhydro sugars

KW - Chiral piperazines

KW - Piperazine derivatives

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U2 - 10.1016/S0040-4039(98)01677-3

DO - 10.1016/S0040-4039(98)01677-3

M3 - Article

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SN - 0040-4039

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EP - 7704

JO - Tetrahedron Letters

JF - Tetrahedron Letters

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ER -

A stereospecific synthesis of tetra-substituted chiral piperazines

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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