A stereospecific synthesis of tetra-substituted chiral piperazines

Raid J. Abdel-Jalil, Raed A. Al-Qawasmeh, Yousef Al-Abed, Wolfgang Voelter

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A one pot reaction of the epoxy triflates 1 or 2 with a variety of N',N'-disubstituted ethylenediamines yields the corresponding chiral piperazine derivatives 3a-e and 4a-e of potential pharmacological interest in high yields.

Original languageEnglish
Pages (from-to)7703-7704
Number of pages2
JournalTetrahedron Letters
Volume39
Issue number42
Publication statusPublished - Oct 15 1998

Fingerprint

Ethylenediamines
Piperazines
Pharmacology
Derivatives
piperazine

Keywords

  • Anhydro sugars
  • Chiral piperazines
  • Piperazine derivatives

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Abdel-Jalil, R. J., Al-Qawasmeh, R. A., Al-Abed, Y., & Voelter, W. (1998). A stereospecific synthesis of tetra-substituted chiral piperazines. Tetrahedron Letters, 39(42), 7703-7704.

A stereospecific synthesis of tetra-substituted chiral piperazines. / Abdel-Jalil, Raid J.; Al-Qawasmeh, Raed A.; Al-Abed, Yousef; Voelter, Wolfgang.

In: Tetrahedron Letters, Vol. 39, No. 42, 15.10.1998, p. 7703-7704.

Research output: Contribution to journalArticle

Abdel-Jalil, RJ, Al-Qawasmeh, RA, Al-Abed, Y & Voelter, W 1998, 'A stereospecific synthesis of tetra-substituted chiral piperazines', Tetrahedron Letters, vol. 39, no. 42, pp. 7703-7704.
Abdel-Jalil RJ, Al-Qawasmeh RA, Al-Abed Y, Voelter W. A stereospecific synthesis of tetra-substituted chiral piperazines. Tetrahedron Letters. 1998 Oct 15;39(42):7703-7704.
Abdel-Jalil, Raid J. ; Al-Qawasmeh, Raed A. ; Al-Abed, Yousef ; Voelter, Wolfgang. / A stereospecific synthesis of tetra-substituted chiral piperazines. In: Tetrahedron Letters. 1998 ; Vol. 39, No. 42. pp. 7703-7704.
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