A stereospecific synthesis of tetra-substituted chiral piperazines

Raid J. Abdel-Jalil, Raed A. Al-Qawasmeh, Yousef Al-Abed, Wolfgang Voelter

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A one pot reaction of the epoxy triflates 1 or 2 with a variety of N',N'-disubstituted ethylenediamines yields the corresponding chiral piperazine derivatives 3a-e and 4a-e of potential pharmacological interest in high yields.

Original languageEnglish
Pages (from-to)7703-7704
Number of pages2
JournalTetrahedron Letters
Volume39
Issue number42
Publication statusPublished - Oct 15 1998

Keywords

  • Anhydro sugars
  • Chiral piperazines
  • Piperazine derivatives

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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  • Cite this

    Abdel-Jalil, R. J., Al-Qawasmeh, R. A., Al-Abed, Y., & Voelter, W. (1998). A stereospecific synthesis of tetra-substituted chiral piperazines. Tetrahedron Letters, 39(42), 7703-7704.