A solid-state sensor based on poly(2,4,6-triaminopyrimidine) grafted with electrochemically reduced graphene oxide

Fabrication, characterization, kinetics and potential analysis on ephedrine

Research output: Contribution to journalArticle

Abstract

A catalytic surface was fabricated by incorporation of electrochemically reduced graphene oxide (rGO) on poly(2,4,6-triaminopyrimidine) (PTAP) film modified glassy carbon electrode. The surface materials of the constructed electrode (rGO.PTAP/GCE) were characterized by means of electrochemical and surface scanning techniques including Cyclic Voltammetry (CV), Electrochemical Impedance Spectroscopy (EIS) and X-ray Photoelectrons Spectroscopy (XPS). Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM) were carried out to identify the preparation of the graphene oxide (GO). The heterogeneous rate constant (k s = 0.149 cm s −1 ) of the fabricated sensor was evaluated by Nicholson method. The synergistic effect of surface materials promotes the catalytic efficiency of the developed sensor for the detection of ephedrine (EPH) in pharmaceutical samples where the detection limit (DL ) of EPH was 1.8 μM (297 ppb). The diffusion coefficient of ephedrine (2.55 × 10 −5 cm 2 ·s −1 ) was also evaluated using theoretical electrochemical approach. The analytical performance of the sensor was successfully applied for real drug sample with acceptable analytical recovery percentage.

Original languageEnglish
Pages (from-to)444-453
Number of pages10
JournalMicrochemical Journal
Volume147
DOIs
Publication statusPublished - Jun 1 2019

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Solid-state sensors
Ephedrine
Graphite
Oxides
Fabrication
Kinetics
Sensors
Electrodes
Glassy carbon
Electrochemical impedance spectroscopy
Pharmaceutical Preparations
Cyclic voltammetry
Rate constants
X ray photoelectron spectroscopy
Scanning
Recovery
Scanning electron microscopy
2,4,6-triaminopyrimidine

Keywords

  • Ephedrine
  • Poly(2,4,6-triaminopyrimidine)
  • Reduced graphene oxide
  • Solid-state sensor

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

Cite this

@article{67aeec4f06ee4536a9c77a14fd206fce,
title = "A solid-state sensor based on poly(2,4,6-triaminopyrimidine) grafted with electrochemically reduced graphene oxide: Fabrication, characterization, kinetics and potential analysis on ephedrine",
abstract = "A catalytic surface was fabricated by incorporation of electrochemically reduced graphene oxide (rGO) on poly(2,4,6-triaminopyrimidine) (PTAP) film modified glassy carbon electrode. The surface materials of the constructed electrode (rGO.PTAP/GCE) were characterized by means of electrochemical and surface scanning techniques including Cyclic Voltammetry (CV), Electrochemical Impedance Spectroscopy (EIS) and X-ray Photoelectrons Spectroscopy (XPS). Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM) were carried out to identify the preparation of the graphene oxide (GO). The heterogeneous rate constant (k s = 0.149 cm s −1 ) of the fabricated sensor was evaluated by Nicholson method. The synergistic effect of surface materials promotes the catalytic efficiency of the developed sensor for the detection of ephedrine (EPH) in pharmaceutical samples where the detection limit (DL 3σ ) of EPH was 1.8 μM (297 ppb). The diffusion coefficient of ephedrine (2.55 × 10 −5 cm 2 ·s −1 ) was also evaluated using theoretical electrochemical approach. The analytical performance of the sensor was successfully applied for real drug sample with acceptable analytical recovery percentage.",
keywords = "Ephedrine, Poly(2,4,6-triaminopyrimidine), Reduced graphene oxide, Solid-state sensor",
author = "Emad Khudaish and Myint, {Myo T.Z.} and Jahangir Rather",
year = "2019",
month = "6",
day = "1",
doi = "10.1016/j.microc.2019.03.041",
language = "English",
volume = "147",
pages = "444--453",
journal = "Microchemical Journal",
issn = "0026-265X",
publisher = "Elsevier Inc.",

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T1 - A solid-state sensor based on poly(2,4,6-triaminopyrimidine) grafted with electrochemically reduced graphene oxide

T2 - Fabrication, characterization, kinetics and potential analysis on ephedrine

AU - Khudaish, Emad

AU - Myint, Myo T.Z.

AU - Rather, Jahangir

PY - 2019/6/1

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N2 - A catalytic surface was fabricated by incorporation of electrochemically reduced graphene oxide (rGO) on poly(2,4,6-triaminopyrimidine) (PTAP) film modified glassy carbon electrode. The surface materials of the constructed electrode (rGO.PTAP/GCE) were characterized by means of electrochemical and surface scanning techniques including Cyclic Voltammetry (CV), Electrochemical Impedance Spectroscopy (EIS) and X-ray Photoelectrons Spectroscopy (XPS). Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM) were carried out to identify the preparation of the graphene oxide (GO). The heterogeneous rate constant (k s = 0.149 cm s −1 ) of the fabricated sensor was evaluated by Nicholson method. The synergistic effect of surface materials promotes the catalytic efficiency of the developed sensor for the detection of ephedrine (EPH) in pharmaceutical samples where the detection limit (DL 3σ ) of EPH was 1.8 μM (297 ppb). The diffusion coefficient of ephedrine (2.55 × 10 −5 cm 2 ·s −1 ) was also evaluated using theoretical electrochemical approach. The analytical performance of the sensor was successfully applied for real drug sample with acceptable analytical recovery percentage.

AB - A catalytic surface was fabricated by incorporation of electrochemically reduced graphene oxide (rGO) on poly(2,4,6-triaminopyrimidine) (PTAP) film modified glassy carbon electrode. The surface materials of the constructed electrode (rGO.PTAP/GCE) were characterized by means of electrochemical and surface scanning techniques including Cyclic Voltammetry (CV), Electrochemical Impedance Spectroscopy (EIS) and X-ray Photoelectrons Spectroscopy (XPS). Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM) were carried out to identify the preparation of the graphene oxide (GO). The heterogeneous rate constant (k s = 0.149 cm s −1 ) of the fabricated sensor was evaluated by Nicholson method. The synergistic effect of surface materials promotes the catalytic efficiency of the developed sensor for the detection of ephedrine (EPH) in pharmaceutical samples where the detection limit (DL 3σ ) of EPH was 1.8 μM (297 ppb). The diffusion coefficient of ephedrine (2.55 × 10 −5 cm 2 ·s −1 ) was also evaluated using theoretical electrochemical approach. The analytical performance of the sensor was successfully applied for real drug sample with acceptable analytical recovery percentage.

KW - Ephedrine

KW - Poly(2,4,6-triaminopyrimidine)

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