A reanalysis of pain crises data from the pivotal L-glutamine in sickle cell disease trial

Ahmar U. Zaidi*, Jeremie Estepp, Nirmish Shah, Salam Alkindi, Hatoon Ezzat, Hung Lam, Caterina P. Minniti

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The pivotal Endari trial in sickle cell disease showed a reduction in pain crises events. This reanalysis of the L-glutamine phase 3 trial using annual rates of pain crises, consistent with other SCD studies, supported the statistically significant outcomes of the original analysis. The observed 45% difference in the VOC rate is comparable to what was reported in other sickle cell therapeutics used to reduce the incidence of pain. The results presented in this communication are informative for clinicians evaluating treatment effects across available SCD therapeutic options based on studies that utilized VOC as the primary endpoint.

Original languageEnglish
Article number106546
JournalContemporary Clinical Trials
Volume110
DOIs
Publication statusPublished - Nov 2021

Keywords

  • Annual crisis rate
  • Endari
  • L-glutamine
  • Pain crises
  • Sickle cell disease

ASJC Scopus subject areas

  • Pharmacology (medical)

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