A rapid, mild, efficient, and solvent-free Friedel-Crafts acylation of N-acetyltetrahydroharmine

Sabira Begum, Syed Imran Hassan, Bina S. Siddiqui

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3 Citations (Scopus)

Abstract

The first solid-phase, rapid, and mild synthesis of 10-acyl and 12-acyl analogues of N-acetyltetrahydroharmine by Friedel-Crafts acylation has been developed. The products were obtained in high overall yields. The method also results in the high-yield synthesis of natural product jafrine.

Original languageEnglish
Pages (from-to)23-39
Number of pages17
JournalSynthetic Communications
Volume35
Issue number1
DOIs
Publication statusPublished - 2005

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Keywords

  • β-carboline
  • Acyl N-acetyltetrahydroharmines
  • Friedel-Crafts acylation
  • N-acetyltetrahydroharmine
  • Solid-phase reaction

ASJC Scopus subject areas

  • Organic Chemistry

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