A radiological profile of fungal sinusitis

Suresh Pillai, Ajay M. Bhandarkar, Suraj S. Nair, Anusha Taarinie Jha, Balakrishnan Ramaswamy, Rashid Al-Abri

Research output: Contribution to journalArticle

Abstract

Objectives: To create a radiological profile of fungal sinusitis and determine the radiological differences between fungal and nonfungal sinusitis based on the presence of hyperattenuation, bony erosion, neo-osteogenesis, air-fluid level, and extrasinus extension. Methods: This is a retrospective, single-blind, case-control study involving the analysis of 119 computed tomography (CT) scans of the paranasal sinuses. Based on the histopathology, they were divided into cases comprising fungal sinusitis and controls of nonfungal sinusitis. Benign and malignant tumors and previously operated cases of fungal sinusitis were excluded from the study. The principal investigators were blinded to the diagnosis. The comparison parameters were hyperattenuation, the presence of air-fluid level, bone erosion, neo-osteogenesis, and extrasinus extension. Data was analyzed by Chi-square and Fischer exact t-test using SPSS 14.0 software and a p < 0.05 was considered significant. Results: Our study showed the presence of hyperattenuation, neo-osteogenesis, bone erosion, air-fluid level, extrasinus extension in 75.2%, 48.3%, 25.9%, 36.2%, and 6.9% of the cases and 13.1%, 16.4%, 6.6%, 9.8%, and 0 controls, respectively. All the parameters were statistically significant in cases when compared to controls. Conclusion: Hyperattenuation, neo-osteogenesis, air-fluid level, bone erosion, and extrasinus extension are the parameters on CT imaging that will help routinely assess and differentiate fungal sinusitis from nonfungal sinusitis with considerable accuracy, although, there is an overlap with malignancy when the parameter of bone erosion is considered as a differential diagnosis of chronic invasive fungal sinusitis. It reiterates the fact that history, clinical examination, and laboratory evaluation hold an important role in provisional diagnosis.

Original languageEnglish
Pages (from-to)331-334
Number of pages4
JournalAsian Journal of Pharmaceutical and Clinical Research
Volume10
Issue number9
DOIs
Publication statusPublished - 2017

Fingerprint

Sinusitis
Osteogenesis
Air
Bone and Bones
Tomography
Paranasal Sinuses
Case-Control Studies
Neoplasms
Differential Diagnosis
Software
History
Research Personnel

Keywords

  • Acute invasive fungal sinusitis
  • Allergic fungal sinusitis
  • Bone erosion
  • Chronic granulomatous sinusitis
  • Chronic invasive sinusitis
  • Fungal sinusitis
  • Fungus ball
  • Hyperattenuation
  • Neo-osteogenesis

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Pharmacology (medical)

Cite this

A radiological profile of fungal sinusitis. / Pillai, Suresh; Bhandarkar, Ajay M.; Nair, Suraj S.; Jha, Anusha Taarinie; Ramaswamy, Balakrishnan; Al-Abri, Rashid.

In: Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, No. 9, 2017, p. 331-334.

Research output: Contribution to journalArticle

Pillai, Suresh ; Bhandarkar, Ajay M. ; Nair, Suraj S. ; Jha, Anusha Taarinie ; Ramaswamy, Balakrishnan ; Al-Abri, Rashid. / A radiological profile of fungal sinusitis. In: Asian Journal of Pharmaceutical and Clinical Research. 2017 ; Vol. 10, No. 9. pp. 331-334.
@article{20bf48b1ec3f4a1b85c0186b79132ff8,
title = "A radiological profile of fungal sinusitis",
abstract = "Objectives: To create a radiological profile of fungal sinusitis and determine the radiological differences between fungal and nonfungal sinusitis based on the presence of hyperattenuation, bony erosion, neo-osteogenesis, air-fluid level, and extrasinus extension. Methods: This is a retrospective, single-blind, case-control study involving the analysis of 119 computed tomography (CT) scans of the paranasal sinuses. Based on the histopathology, they were divided into cases comprising fungal sinusitis and controls of nonfungal sinusitis. Benign and malignant tumors and previously operated cases of fungal sinusitis were excluded from the study. The principal investigators were blinded to the diagnosis. The comparison parameters were hyperattenuation, the presence of air-fluid level, bone erosion, neo-osteogenesis, and extrasinus extension. Data was analyzed by Chi-square and Fischer exact t-test using SPSS 14.0 software and a p < 0.05 was considered significant. Results: Our study showed the presence of hyperattenuation, neo-osteogenesis, bone erosion, air-fluid level, extrasinus extension in 75.2{\%}, 48.3{\%}, 25.9{\%}, 36.2{\%}, and 6.9{\%} of the cases and 13.1{\%}, 16.4{\%}, 6.6{\%}, 9.8{\%}, and 0 controls, respectively. All the parameters were statistically significant in cases when compared to controls. Conclusion: Hyperattenuation, neo-osteogenesis, air-fluid level, bone erosion, and extrasinus extension are the parameters on CT imaging that will help routinely assess and differentiate fungal sinusitis from nonfungal sinusitis with considerable accuracy, although, there is an overlap with malignancy when the parameter of bone erosion is considered as a differential diagnosis of chronic invasive fungal sinusitis. It reiterates the fact that history, clinical examination, and laboratory evaluation hold an important role in provisional diagnosis.",
keywords = "Acute invasive fungal sinusitis, Allergic fungal sinusitis, Bone erosion, Chronic granulomatous sinusitis, Chronic invasive sinusitis, Fungal sinusitis, Fungus ball, Hyperattenuation, Neo-osteogenesis",
author = "Suresh Pillai and Bhandarkar, {Ajay M.} and Nair, {Suraj S.} and Jha, {Anusha Taarinie} and Balakrishnan Ramaswamy and Rashid Al-Abri",
year = "2017",
doi = "10.22159/ajpcr.2017.v10i9.19837",
language = "English",
volume = "10",
pages = "331--334",
journal = "Asian Journal of Pharmaceutical and Clinical Research",
issn = "0974-2441",
publisher = "Asian Journal of Pharmaceutical and Clinical Research",
number = "9",

}

TY - JOUR

T1 - A radiological profile of fungal sinusitis

AU - Pillai, Suresh

AU - Bhandarkar, Ajay M.

AU - Nair, Suraj S.

AU - Jha, Anusha Taarinie

AU - Ramaswamy, Balakrishnan

AU - Al-Abri, Rashid

PY - 2017

Y1 - 2017

N2 - Objectives: To create a radiological profile of fungal sinusitis and determine the radiological differences between fungal and nonfungal sinusitis based on the presence of hyperattenuation, bony erosion, neo-osteogenesis, air-fluid level, and extrasinus extension. Methods: This is a retrospective, single-blind, case-control study involving the analysis of 119 computed tomography (CT) scans of the paranasal sinuses. Based on the histopathology, they were divided into cases comprising fungal sinusitis and controls of nonfungal sinusitis. Benign and malignant tumors and previously operated cases of fungal sinusitis were excluded from the study. The principal investigators were blinded to the diagnosis. The comparison parameters were hyperattenuation, the presence of air-fluid level, bone erosion, neo-osteogenesis, and extrasinus extension. Data was analyzed by Chi-square and Fischer exact t-test using SPSS 14.0 software and a p < 0.05 was considered significant. Results: Our study showed the presence of hyperattenuation, neo-osteogenesis, bone erosion, air-fluid level, extrasinus extension in 75.2%, 48.3%, 25.9%, 36.2%, and 6.9% of the cases and 13.1%, 16.4%, 6.6%, 9.8%, and 0 controls, respectively. All the parameters were statistically significant in cases when compared to controls. Conclusion: Hyperattenuation, neo-osteogenesis, air-fluid level, bone erosion, and extrasinus extension are the parameters on CT imaging that will help routinely assess and differentiate fungal sinusitis from nonfungal sinusitis with considerable accuracy, although, there is an overlap with malignancy when the parameter of bone erosion is considered as a differential diagnosis of chronic invasive fungal sinusitis. It reiterates the fact that history, clinical examination, and laboratory evaluation hold an important role in provisional diagnosis.

AB - Objectives: To create a radiological profile of fungal sinusitis and determine the radiological differences between fungal and nonfungal sinusitis based on the presence of hyperattenuation, bony erosion, neo-osteogenesis, air-fluid level, and extrasinus extension. Methods: This is a retrospective, single-blind, case-control study involving the analysis of 119 computed tomography (CT) scans of the paranasal sinuses. Based on the histopathology, they were divided into cases comprising fungal sinusitis and controls of nonfungal sinusitis. Benign and malignant tumors and previously operated cases of fungal sinusitis were excluded from the study. The principal investigators were blinded to the diagnosis. The comparison parameters were hyperattenuation, the presence of air-fluid level, bone erosion, neo-osteogenesis, and extrasinus extension. Data was analyzed by Chi-square and Fischer exact t-test using SPSS 14.0 software and a p < 0.05 was considered significant. Results: Our study showed the presence of hyperattenuation, neo-osteogenesis, bone erosion, air-fluid level, extrasinus extension in 75.2%, 48.3%, 25.9%, 36.2%, and 6.9% of the cases and 13.1%, 16.4%, 6.6%, 9.8%, and 0 controls, respectively. All the parameters were statistically significant in cases when compared to controls. Conclusion: Hyperattenuation, neo-osteogenesis, air-fluid level, bone erosion, and extrasinus extension are the parameters on CT imaging that will help routinely assess and differentiate fungal sinusitis from nonfungal sinusitis with considerable accuracy, although, there is an overlap with malignancy when the parameter of bone erosion is considered as a differential diagnosis of chronic invasive fungal sinusitis. It reiterates the fact that history, clinical examination, and laboratory evaluation hold an important role in provisional diagnosis.

KW - Acute invasive fungal sinusitis

KW - Allergic fungal sinusitis

KW - Bone erosion

KW - Chronic granulomatous sinusitis

KW - Chronic invasive sinusitis

KW - Fungal sinusitis

KW - Fungus ball

KW - Hyperattenuation

KW - Neo-osteogenesis

UR - http://www.scopus.com/inward/record.url?scp=85029573081&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029573081&partnerID=8YFLogxK

U2 - 10.22159/ajpcr.2017.v10i9.19837

DO - 10.22159/ajpcr.2017.v10i9.19837

M3 - Article

VL - 10

SP - 331

EP - 334

JO - Asian Journal of Pharmaceutical and Clinical Research

JF - Asian Journal of Pharmaceutical and Clinical Research

SN - 0974-2441

IS - 9

ER -