A pilot assessment of oxidative stress byproducts and antioxidant activities among indian patients with various stages of hypertension

Raman Saraswathi, Devarajan Sankar, Amanat Ali, Yoshinari Uehara, Satomi Abe, Ganapathy Sambandam, M. Ramakrishna Rao

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6 Citations (Scopus)


In humans, hypertension is considered a state of oxidative stress that can contribute to the development of atherosclerosis and other hypertension-induced organ damages. The objective of this study was to evaluate oxidative status, antioxidant activities, and oxidative stress by-products among Indian patients with various stages of hypertension. Lipid profile, enzymatic and non-enzymatic antioxidants, lipid peroxidation as thiobarbituric acid reactive substances (TBARS), C-reactive protein, electrolytes, and minerals were analyzed in the blood of newly diagnosed prehypertensives, stage I and II hypertensives (n = 20 in each group) and were compared to their age-matched normotensives. Elevated levels of lipid profile (except high density lipoprotein cholesterol [HDL-C]) were observed in stage I and II hypertensive patients. Enzymatic and non-enzymatic antioxidants were significantly (P <0.05) lower, while TBARS and C-reactive protein were higher in prehypertensives, and stage I and II hypertensives. Significant (P + and K + concentrations among the hypertensive groups. Serum levels of zinc, copper, and magnesium were significantly (P <0.05) lower in prehypertensives, and stage I and II hypertensives as compared to normotensives. The study indicated a strong association between blood pressure (BP) and oxidative stress-related parameters and suggests a possible role of oxidative stress in the development of elevated BP.

Original languageEnglish
Pages (from-to)437-443
Number of pages7
JournalClinical and Experimental Hypertension
Issue number7
Publication statusPublished - Nov 2011



  • Antioxidants
  • Lipid peroxidation
  • Oxidative stress

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

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