A pilot assessment of oxidative stress byproducts and antioxidant activities among indian patients with various stages of hypertension

Raman Saraswathi, Devarajan Sankar*, Amanat Ali, Yoshinari Uehara, Satomi Abe, Ganapathy Sambandam, M. Ramakrishna Rao

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

In humans, hypertension is considered a state of oxidative stress that can contribute to the development of atherosclerosis and other hypertension-induced organ damages. The objective of this study was to evaluate oxidative status, antioxidant activities, and oxidative stress by-products among Indian patients with various stages of hypertension. Lipid profile, enzymatic and non-enzymatic antioxidants, lipid peroxidation as thiobarbituric acid reactive substances (TBARS), C-reactive protein, electrolytes, and minerals were analyzed in the blood of newly diagnosed prehypertensives, stage I and II hypertensives (n = 20 in each group) and were compared to their age-matched normotensives. Elevated levels of lipid profile (except high density lipoprotein cholesterol [HDL-C]) were observed in stage I and II hypertensive patients. Enzymatic and non-enzymatic antioxidants were significantly (P <0.05) lower, while TBARS and C-reactive protein were higher in prehypertensives, and stage I and II hypertensives. Significant (P + and K + concentrations among the hypertensive groups. Serum levels of zinc, copper, and magnesium were significantly (P <0.05) lower in prehypertensives, and stage I and II hypertensives as compared to normotensives. The study indicated a strong association between blood pressure (BP) and oxidative stress-related parameters and suggests a possible role of oxidative stress in the development of elevated BP.

Original languageEnglish
Pages (from-to)437-443
Number of pages7
JournalClinical and Experimental Hypertension
Volume33
Issue number7
DOIs
Publication statusPublished - Nov 2011

Keywords

  • Antioxidants
  • Lipid peroxidation
  • Oxidative stress

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

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