A novel method for the synthesis of 4(3H)-quinazolinones

Raid J. Abdel-Jalil; Wolfgang Voelter; Muhammad Saeed

doi:10.1016/j.tetlet.2004.03.003

A novel method for the synthesis of 4(3H)-quinazolinones

Raid J. Abdel-Jalil^*, Wolfgang Voelter, Muhammad Saeed

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

270 Citations (Scopus)

Abstract

Condensation of anthranilamide with aryl, alkyl or heteroaryl aldehydes in refluxing ethanol and the presence of CuCl₂ afforded the corresponding 2-substituted quinazolinones in excellent yields.

Original language	English
Pages (from-to)	3475-3476
Number of pages	2
Journal	Tetrahedron Letters
Volume	45
Issue number	17
DOIs	https://doi.org/10.1016/j.tetlet.2004.03.003
Publication status	Published - Apr 19 2004
Externally published	Yes

Keywords

Anthranilimide
Quinazolinone
Schiff base
Synthesis

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/j.tetlet.2004.03.003

Cite this

@article{ebc9bce206144592bd343acd60df46da,

title = "A novel method for the synthesis of 4(3H)-quinazolinones",

abstract = "Condensation of anthranilamide with aryl, alkyl or heteroaryl aldehydes in refluxing ethanol and the presence of CuCl2 afforded the corresponding 2-substituted quinazolinones in excellent yields.",

keywords = "Anthranilimide, Quinazolinone, Schiff base, Synthesis",

author = "Abdel-Jalil, {Raid J.} and Wolfgang Voelter and Muhammad Saeed",

note = "Funding Information: We would like to thank Dr. Monther Khnafar and Mr. Ehab El-Moumany for the assistance with the NMR experiments. Financial support, provided by the Hashemite University, is greatly acknowledged. We express our gratitude to Internationales B{\"u}ro of BMBF, J{\"u}lich, for a fellowship granted to Dr. R. J. A.-J.",

year = "2004",

month = apr,

day = "19",

doi = "10.1016/j.tetlet.2004.03.003",

language = "English",

volume = "45",

pages = "3475--3476",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "17",

}

TY - JOUR

T1 - A novel method for the synthesis of 4(3H)-quinazolinones

AU - Abdel-Jalil, Raid J.

AU - Voelter, Wolfgang

AU - Saeed, Muhammad

N1 - Funding Information: We would like to thank Dr. Monther Khnafar and Mr. Ehab El-Moumany for the assistance with the NMR experiments. Financial support, provided by the Hashemite University, is greatly acknowledged. We express our gratitude to Internationales Büro of BMBF, Jülich, for a fellowship granted to Dr. R. J. A.-J.

PY - 2004/4/19

Y1 - 2004/4/19

N2 - Condensation of anthranilamide with aryl, alkyl or heteroaryl aldehydes in refluxing ethanol and the presence of CuCl2 afforded the corresponding 2-substituted quinazolinones in excellent yields.

AB - Condensation of anthranilamide with aryl, alkyl or heteroaryl aldehydes in refluxing ethanol and the presence of CuCl2 afforded the corresponding 2-substituted quinazolinones in excellent yields.

KW - Anthranilimide

KW - Quinazolinone

KW - Schiff base

KW - Synthesis

UR - http://www.scopus.com/inward/record.url?scp=1842637263&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1842637263&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2004.03.003

DO - 10.1016/j.tetlet.2004.03.003

M3 - Article

AN - SCOPUS:1842637263

SN - 0040-4039

VL - 45

SP - 3475

EP - 3476

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 17

ER -

A novel method for the synthesis of 4(3H)-quinazolinones

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this