A general method for the selective reduction of ketones in the presence of enones.

Dale E. Ward, Chung K. Rhee, Wajdi M. Zoghaib

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Ketones can be reduced in the presence of conjugated enones by sodiumborohydride in 50% methanol in dichloromethane at -78°C. The selectivity is generally excellent. In favorable cases the reaction can be carried out at room temperature in dichloromethane with acetic acid as catalyst.

Original languageEnglish
Pages (from-to)517-520
Number of pages4
JournalTetrahedron Letters
Volume29
Issue number5
DOIs
Publication statusPublished - 1988

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Methylene Chloride
Ketones
Acetic Acid
Methanol
Catalysts
Temperature

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

A general method for the selective reduction of ketones in the presence of enones. / Ward, Dale E.; Rhee, Chung K.; Zoghaib, Wajdi M.

In: Tetrahedron Letters, Vol. 29, No. 5, 1988, p. 517-520.

Research output: Contribution to journalArticle

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