A general method for the selective reduction of ketones in the presence of enones.

Dale E. Ward, Chung K. Rhee, Wajdi M. Zoghaib

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Ketones can be reduced in the presence of conjugated enones by sodiumborohydride in 50% methanol in dichloromethane at -78°C. The selectivity is generally excellent. In favorable cases the reaction can be carried out at room temperature in dichloromethane with acetic acid as catalyst.

Original languageEnglish
Pages (from-to)517-520
Number of pages4
JournalTetrahedron Letters
Issue number5
Publication statusPublished - 1988


ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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