A general method for the selective reduction of ketones in the presence of enones.

Dale E. Ward*, Chung K. Rhee, Wajdi M. Zoghaib

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

Ketones can be reduced in the presence of conjugated enones by sodiumborohydride in 50% methanol in dichloromethane at -78°C. The selectivity is generally excellent. In favorable cases the reaction can be carried out at room temperature in dichloromethane with acetic acid as catalyst.

Original languageEnglish
Pages (from-to)517-520
Number of pages4
JournalTetrahedron Letters
Volume29
Issue number5
DOIs
Publication statusPublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'A general method for the selective reduction of ketones in the presence of enones.'. Together they form a unique fingerprint.

Cite this