A delay differential equation mathematical model for the control of the hormonal system of the hypothalamus, the pituitary and the testis in man

David Greenhalgh, Q. J A Khan

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

In this paper we develop previously studied mathematical models of the regulation of testosterone by luteinizing hormone and luteinizing hormone release hormone in the human body. We propose a delay differential equation mathematical model which improves on earlier simpler models by taking into account observed experimental facts. We show that our model has four possible equilibria, but only one unique equilibrium where all three hormones are present. We perform stability and Hopf bifurcation analyses on the equilibrium where all three hormones are present. With no time delay, this equilibrium is unstable, but as the time delay increases through an infinite sequence of positive values, Hopf bifurcation occurs repeatedly. This is of practical interest as biological evidence shows that the levels of these hormones in the body oscillate periodically. We next discuss stability of the other equilibria heuristically using analytical methods. Then we describe simulations with realistic parameter values and show that our model can mimic the regular fluctuations of the three hormones in the body and explore, numerically, some of our heuristic conjectures. A brief discussion concludes the paper.

Original languageEnglish
JournalNonlinear Analysis, Theory, Methods and Applications
Volume71
Issue number12
DOIs
Publication statusPublished - Dec 15 2009

Fingerprint

Hormones
Delay Differential Equations
Differential equations
Mathematical Model
Mathematical models
Hopf bifurcation
Hopf Bifurcation
Time Delay
Time delay
Analytical Methods
Unstable
Model
Heuristics
Fluctuations
Simulation

Keywords

  • Differential equations
  • Equilibrium and stability analysis
  • Hopf bifurcation
  • Human hormonal systems
  • Limit cycles
  • Luteinizing hormone
  • Luteinizing hormone release hormone
  • Testosterone
  • Time delay

ASJC Scopus subject areas

  • Analysis
  • Applied Mathematics

Cite this

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abstract = "In this paper we develop previously studied mathematical models of the regulation of testosterone by luteinizing hormone and luteinizing hormone release hormone in the human body. We propose a delay differential equation mathematical model which improves on earlier simpler models by taking into account observed experimental facts. We show that our model has four possible equilibria, but only one unique equilibrium where all three hormones are present. We perform stability and Hopf bifurcation analyses on the equilibrium where all three hormones are present. With no time delay, this equilibrium is unstable, but as the time delay increases through an infinite sequence of positive values, Hopf bifurcation occurs repeatedly. This is of practical interest as biological evidence shows that the levels of these hormones in the body oscillate periodically. We next discuss stability of the other equilibria heuristically using analytical methods. Then we describe simulations with realistic parameter values and show that our model can mimic the regular fluctuations of the three hormones in the body and explore, numerically, some of our heuristic conjectures. A brief discussion concludes the paper.",
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N2 - In this paper we develop previously studied mathematical models of the regulation of testosterone by luteinizing hormone and luteinizing hormone release hormone in the human body. We propose a delay differential equation mathematical model which improves on earlier simpler models by taking into account observed experimental facts. We show that our model has four possible equilibria, but only one unique equilibrium where all three hormones are present. We perform stability and Hopf bifurcation analyses on the equilibrium where all three hormones are present. With no time delay, this equilibrium is unstable, but as the time delay increases through an infinite sequence of positive values, Hopf bifurcation occurs repeatedly. This is of practical interest as biological evidence shows that the levels of these hormones in the body oscillate periodically. We next discuss stability of the other equilibria heuristically using analytical methods. Then we describe simulations with realistic parameter values and show that our model can mimic the regular fluctuations of the three hormones in the body and explore, numerically, some of our heuristic conjectures. A brief discussion concludes the paper.

AB - In this paper we develop previously studied mathematical models of the regulation of testosterone by luteinizing hormone and luteinizing hormone release hormone in the human body. We propose a delay differential equation mathematical model which improves on earlier simpler models by taking into account observed experimental facts. We show that our model has four possible equilibria, but only one unique equilibrium where all three hormones are present. We perform stability and Hopf bifurcation analyses on the equilibrium where all three hormones are present. With no time delay, this equilibrium is unstable, but as the time delay increases through an infinite sequence of positive values, Hopf bifurcation occurs repeatedly. This is of practical interest as biological evidence shows that the levels of these hormones in the body oscillate periodically. We next discuss stability of the other equilibria heuristically using analytical methods. Then we describe simulations with realistic parameter values and show that our model can mimic the regular fluctuations of the three hormones in the body and explore, numerically, some of our heuristic conjectures. A brief discussion concludes the paper.

KW - Differential equations

KW - Equilibrium and stability analysis

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KW - Limit cycles

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KW - Luteinizing hormone release hormone

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KW - Time delay

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