A coarse grained model for DNA and polymer packaging: Statics and dynamics

Issam Ali, Davide Marenduzzo, C. Micheletti, J. M. Yeomans

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We present a numerical characterization of the statics and dynamics of the packaging of a semi-flexible polymer inside a sphere. The study is motivated by recent experiments on the packaging of DNA inside viral capsids. It is found that the force required to confine the coarse-grained polymer is in fair agreement with that found in experiments for the packaging of the phi29 bacteriophage genome. Despite its schematic nature, the model is capable of reproducing the most salient dynamical features of packaging experiments such as the presence of pauses during individual packaging processes and the trend of the resisting force as a function of chain packed fraction.

Original languageEnglish
Pages (from-to)115-117
Number of pages3
JournalJournal of Theoretical Medicine
Volume6
Issue number2
DOIs
Publication statusPublished - Jun 2005

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Keywords

  • Bacteriophages
  • DNA packaging
  • Polymer physics
  • Statistical mechanics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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