A β-carboline-1-one mimic of the anticancer Amaryllidaceae constituent pancratistatin: Synthesis and biological evaluation

Uwe Rinner, Tomas Hudlicky, Heather Gordon, George R. Pettit

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71 Citations (Scopus)


New drug design possibilities are suggested by the results of a biological evaluation of the indole derivative 1 of pancratistatin, a known anticancer agent, in a panel of cancer cell lines. Enzymatic dihydroxylation was one of the key steps in the short, enantioselective synthesis of 1.

Original languageEnglish
Pages (from-to)5342-5346
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number40
Publication statusPublished - Oct 11 2004



  • Antitumor agents
  • Asymmetric synthesis
  • Natural products
  • Pancratistatin
  • Synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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