A β-carboline-1-one mimic of the anticancer Amaryllidaceae constituent pancratistatin: Synthesis and biological evaluation

Uwe Rinner; Tomas Hudlicky; Heather Gordon; George R. Pettit

doi:10.1002/anie.200460218

A β-carboline-1-one mimic of the anticancer Amaryllidaceae constituent pancratistatin: Synthesis and biological evaluation

Uwe Rinner, Tomas Hudlicky^*, Heather Gordon, George R. Pettit

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

New drug design possibilities are suggested by the results of a biological evaluation of the indole derivative 1 of pancratistatin, a known anticancer agent, in a panel of cancer cell lines. Enzymatic dihydroxylation was one of the key steps in the short, enantioselective synthesis of 1.

Original language	English
Pages (from-to)	5342-5346
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	43
Issue number	40
DOIs	https://doi.org/10.1002/anie.200460218
Publication status	Published - Oct 11 2004
Externally published	Yes

Keywords

Antitumor agents
Asymmetric synthesis
Natural products
Pancratistatin
Synthetic methods

ASJC Scopus subject areas

Catalysis
General Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.200460218

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abstract = "New drug design possibilities are suggested by the results of a biological evaluation of the indole derivative 1 of pancratistatin, a known anticancer agent, in a panel of cancer cell lines. Enzymatic dihydroxylation was one of the key steps in the short, enantioselective synthesis of 1.",

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AU - Pettit, George R.

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KW - Asymmetric synthesis

KW - Natural products

KW - Pancratistatin

KW - Synthetic methods

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A β-carboline-1-one mimic of the anticancer Amaryllidaceae constituent pancratistatin: Synthesis and biological evaluation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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