A β-carboline-1-one mimic of the anticancer Amaryllidaceae constituent pancratistatin: Synthesis and biological evaluation

Uwe Rinner, Tomas Hudlicky*, Heather Gordon, George R. Pettit

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)

Abstract

New drug design possibilities are suggested by the results of a biological evaluation of the indole derivative 1 of pancratistatin, a known anticancer agent, in a panel of cancer cell lines. Enzymatic dihydroxylation was one of the key steps in the short, enantioselective synthesis of 1.

Original languageEnglish
Pages (from-to)5342-5346
Number of pages5
JournalAngewandte Chemie - International Edition
Volume43
Issue number40
DOIs
Publication statusPublished - Oct 11 2004

Keywords

  • Antitumor agents
  • Asymmetric synthesis
  • Natural products
  • Pancratistatin
  • Synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint Dive into the research topics of 'A β-carboline-1-one mimic of the anticancer Amaryllidaceae constituent pancratistatin: Synthesis and biological evaluation'. Together they form a unique fingerprint.

Cite this