A β-carboline-1-one mimic of the anticancer Amaryllidaceae constituent pancratistatin: Synthesis and biological evaluation

Uwe Rinner; Tomas Hudlicky; Heather Gordon; George R. Pettit

doi:10.1002/anie.200460218

A β-carboline-1-one mimic of the anticancer Amaryllidaceae constituent pancratistatin: Synthesis and biological evaluation

Uwe Rinner, Tomas Hudlicky^*, Heather Gordon, George R. Pettit

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

78 Citations (SciVal)

Abstract

New drug design possibilities are suggested by the results of a biological evaluation of the indole derivative 1 of pancratistatin, a known anticancer agent, in a panel of cancer cell lines. Enzymatic dihydroxylation was one of the key steps in the short, enantioselective synthesis of 1.

Original language	English
Pages (from-to)	5342-5346
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	43
Issue number	40
DOIs	https://doi.org/10.1002/anie.200460218
Publication status	Published - Oct 11 2004

Keywords

Antitumor agents
Asymmetric synthesis
Natural products
Pancratistatin
Synthetic methods

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.200460218

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abstract = "New drug design possibilities are suggested by the results of a biological evaluation of the indole derivative 1 of pancratistatin, a known anticancer agent, in a panel of cancer cell lines. Enzymatic dihydroxylation was one of the key steps in the short, enantioselective synthesis of 1.",

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AU - Pettit, George R.

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KW - Asymmetric synthesis

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KW - Synthetic methods

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A β-carboline-1-one mimic of the anticancer Amaryllidaceae constituent pancratistatin: Synthesis and biological evaluation

Abstract

Keywords

ASJC Scopus subject areas

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