A β-carboline-1-one mimic of the anticancer Amaryllidaceae constituent pancratistatin

Synthesis and biological evaluation

Uwe Rinner, Tomas Hudlicky, Heather Gordon, George R. Pettit

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

New drug design possibilities are suggested by the results of a biological evaluation of the indole derivative 1 of pancratistatin, a known anticancer agent, in a panel of cancer cell lines. Enzymatic dihydroxylation was one of the key steps in the short, enantioselective synthesis of 1.

Original languageEnglish
Pages (from-to)5342-5346
Number of pages5
JournalAngewandte Chemie - International Edition
Volume43
Issue number40
DOIs
Publication statusPublished - Oct 11 2004

Fingerprint

Carbolines
Antineoplastic Agents
Cells
Derivatives
Pharmaceutical Preparations
pancratistatin
indole

Keywords

  • Antitumor agents
  • Asymmetric synthesis
  • Natural products
  • Pancratistatin
  • Synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

A β-carboline-1-one mimic of the anticancer Amaryllidaceae constituent pancratistatin : Synthesis and biological evaluation. / Rinner, Uwe; Hudlicky, Tomas; Gordon, Heather; Pettit, George R.

In: Angewandte Chemie - International Edition, Vol. 43, No. 40, 11.10.2004, p. 5342-5346.

Research output: Contribution to journalArticle

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